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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 1
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Research Article

Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes

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Pages 43-55 | Published online: 22 Sep 2008

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Jinyuan Chen, Ziyun Yuan, Yifan Tu, Wanyu Hu, Cong Xie & Ling Ye. (2023) Experimental and computational models to investigate intestinal drug permeability and metabolism. Xenobiotica 53:1, pages 25-45.
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V. Tzankova, C. Ivanova, S. Dragoni, N. Danchev & M. Valoti. (2011) Precision-Cut Slices as a Tool for Studying Phase II Drug Metabolism in Rat Small Intestine in Vitro. Biotechnology & Biotechnological Equipment 25:1, pages 2279-2283.
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R. De Kanter, M. Monshouwer, A. L. Draaisma, M. H. De Jager, I. A. M. De Graaf, J. H. Proost, D. K. F. Meijer & G. M. M. Groothuis. (2004) Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon. Xenobiotica 34:3, pages 229-241.
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Yasuhiro Uno, Shotaro Uehara, Takashi Inoue, Shu Kawamura, Norie Murayama, Miyu Nishikawa, Shinichi Ikushiro, Erika Sasaki & Hiroshi Yamazaki. (2020) Molecular characterization of functional UDP-glucuronosyltransferases 1A and 2B in common marmosets. Biochemical Pharmacology 172, pages 113748.
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Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Yang Chen, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang, Xiaodong Liu & Li Liu. (2019) Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters. Drug Metabolism and Disposition 47:10, pages 1066-1079.
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Yasuhiro Uno, Rika Takahira, Norie Murayama, Yu Ishii, Yoshinori Ikenaka, Mayumi Ishizuka, Hiroshi Yamazaki & Shinichi Ikushiro. (2018) Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques. Biochemical Pharmacology 155, pages 172-181.
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Oliver J.D. Hatley, Christopher R. Jones, Aleksandra Galetin & Amin Rostami‐Hodjegan. (2017) Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors. Biopharmaceutics & Drug Disposition 38:3, pages 187-208.
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Sunday O. Nduka, Mathew J. Okonta, Daniel L. Ajaghaku, Kosisochi C. Amorha & Chinwe V. Ukwe. (2017) Inhibition of cytochrome P450 3A enzyme by Millettia aboensis : its effect on the pharmacokinetic properties of efavirenz and nevirapine. Revista Brasileira de Farmacognosia 27:2, pages 228-235.
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Roshan M. Borkar, Murali Mohan Bhandi, Ajay P. Dubey, V. Ganga Reddy, Prashanth Komirishetty, Prajwal P. Nandekar, Abhay T. Sangamwar, Ahmed Kamal, Sanjay K. Banerjee & R. Srinivas. (2016) An evaluation of the CYP2D6 and CYP3A4 inhibition potential of metoprolol metabolites and their contribution to drug–drug and drug–herb interaction by LC‐ESI/MS/MS. Biomedical Chromatography 30:10, pages 1556-1572.
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Sheila Annie Peters, Christopher R. Jones, Anna-Lena Ungell & Oliver J. D. Hatley. (2016) Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical Models. Clinical Pharmacokinetics 55:6, pages 673-696.
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Erik Sjögren, Bertil Abrahamsson, Patrick Augustijns, Dieter Becker, Michael B. Bolger, Marcus Brewster, Joachim Brouwers, Talia Flanagan, Matthew Harwood, Christian Heinen, René Holm, Hans-Paul Juretschke, Marlies Kubbinga, Anders Lindahl, Viera Lukacova, Uwe Münster, Sibylle Neuhoff, Mai Anh Nguyen, Achiel van Peer, Christos Reppas, Amin Rostami Hodjegan, Christer Tannergren, Werner Weitschies, Clive Wilson, Patricia Zane, Hans Lennernäs & Peter Langguth. (2014) In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects. European Journal of Pharmaceutical Sciences 57, pages 99-151.
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Mahmud Kajbaf, Raffaella Ricci, Serenella Zambon & Stefano Fontana. (2012) Contribution of rat intestinal metabolism to the xenobiotics clearance. European Journal of Drug Metabolism and Pharmacokinetics 38:1, pages 33-41.
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Artur Pałasz, Anna Wiaderkiewicz, Ryszard Wiaderkiewicz, Piotr Czekaj, Beata Czajkowska, Tomasz Lebda-Wyborny, Aneta Piwowarczyk & Aleksandra Bryzek. (2011) Age-related changes in the mRNA levels of CYP1A1, CYP2B1/2 and CYP3A1 isoforms in rat small intestine. Genes & Nutrition 7:2, pages 197-207.
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Wei Zhu & Eun Ju Jeong. 2011. Oral Bioavailability. Oral Bioavailability 461 473 .
Kevin J. Randall, John Turton & John R. Foster. (2011) Explant culture of gastrointestinal tissue: a review of methods and applications. Cell Biology and Toxicology 27:4, pages 267-284.
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Kenji Ikemura, Kimihiko Urano, Hiroko Matsuda, Hideki Mizutani, Takuya Iwamoto & Masahiro Okuda. (2009) Decreased Oral Absorption of Cyclosporine A after Liver Ischemia-Reperfusion Injury in Rats: The Contribution of CYP3A and P-Glycoprotein to the First-Pass Metabolism in Intestinal Epithelial Cells. Journal of Pharmacology and Experimental Therapeutics 328:1, pages 249-255.
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Doreen Mitschke, Andreas Reichel, Gert Fricker & Ursula Moenning. (2008) Characterization of Cytochrome P450 Protein Expression along the Entire Length of the Intestine of Male and Female Rats. Drug Metabolism and Disposition 36:6, pages 1039-1045.
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Hiroshi Komura & Masahiro Iwaki. (2008) Species Differences in In Vitro and In Vivo Small Intestinal Metabolism of CYP3A Substrates. Journal of Pharmaceutical Sciences 97:5, pages 1775-1800.
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Sudhir N. Umathe, Pankaj V. Dixit, Vijendra kumar, Kuldeep U. Bansod & Manish M. Wanjari. (2008) Quercetin pretreatment increases the bioavailability of pioglitazone in rats: Involvement of CYP3A inhibition. Biochemical Pharmacology 75:8, pages 1670-1676.
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Yukio Mori, Kenjiro Tatematsu, Akihiro Koide, Shigeyuki Sugie, Takuji Tanaka & Hideki Mori. (2006) Modification by curcumin of mutagenic activation of carcinogenic N ‐nitrosamines by extrahepatic cytochromes P‐450 2B1 and 2E1 in rats . Cancer Science 97:9, pages 896-904.
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Esther G. van de Kerkhof, Inge A. M. de Graaf, Marina H. de Jager, Dirk K. F. Meijer & Geny M. M. Groothuis. (2005) CHARACTERIZATION OF RAT SMALL INTESTINAL AND COLON PRECISION-CUT SLICES AS AN IN VITRO SYSTEM FOR DRUG METABOLISM AND INDUCTION STUDIES. Drug Metabolism and Disposition 33:11, pages 1613-1620.
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C Arellano, C Philibert, O Lacombe, J Woodley & G Houin. (2004) Liquid chromatographic–mass spectrometric method to assess cytochrome P450-mediated metabolism of testosterone by rat everted gut sacs. Journal of Chromatography B 807:2, pages 263-270.
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