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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 2
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Research Article

Many P-glycoprotein substrates do not inhibit the transport process across cell membranes

M. Barecki-Roach Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, 144 Route 94, PO Box 32, Lafayette, NJ 07848, USA
,
ER-JIA Wang Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, 144 Route 94, PO Box 32, Lafayette, NJ 07848, USA
&
W. W. Johnson Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, 144 Route 94, PO Box 32, Lafayette, NJ 07848, USA
Pages 131-140 | Published online: 22 Sep 2008

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Remigijus Didziapetris, Pranas Japertas, Alex Avdeef & Alanas Petrauskas. (2003) Classification Analysis of P-Glycoprotein Substrate Specificity. Journal of Drug Targeting 11:7, pages 391-406.
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Valentin Tastet, Marc Le Vée, Marie Kerhoas, Anna Zerdoug, Elodie Jouan, Arnaud Bruyère & Olivier Fardel. (2023) Interactions of organophosphate flame retardants with human drug transporters. Ecotoxicology and Environmental Safety 263, pages 115348.
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Im‐Sook Song, Hyeon‐Uk Jeong, Min‐Koo Choi, Mihwa Kwon, Yongho Shin, Jeong Han Kim & Hye‐Suk Lee. (2020) Interactions between cyazofamid and human drug transporters. Journal of Biochemical and Molecular Toxicology 34:4.
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Seyed Sajad Hosseini Balef, Majid Piramoon, Seyed Jalal Hosseinimehr & Hamid Irannejad. (2019) In vitro and in silico evaluation of P-glycoprotein inhibition through 99m Tc-methoxyisobutylisonitrile uptake . Chemical Biology & Drug Design 93:3, pages 283-289.
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Gerard Minuesa, Cristina Arimany-Nardi, Itziar Erkizia, Samandhy Cedeño, José Moltó, Bonaventura Clotet, Marçal Pastor-Anglada & Javier Martinez-Picado. (2016) P-glycoprotein ( ABCB1 ) activity decreases raltegravir disposition in primary CD4+P-gp high cells and correlates with HIV-1 viral load . Journal of Antimicrobial Chemotherapy 71:10, pages 2782-2792.
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Yogendra P. Singh & Ram A. Singh. (2010) Insilico studies of organosulfur-functional active compounds in garlic. BioFactors 36:4, pages 297-311.
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J. Cory Kalvass & Gary M. Pollack. (2006) Kinetic Considerations for the Quantitative Assessment of Efflux Activity and Inhibition: Implications for Understanding and Predicting the Effects of Efflux Inhibition. Pharmaceutical Research 24:2, pages 265-276.
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Guido Hooiveld & Michael Muller. 2007. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference 1 9 .
Thomas J. Raub. (2005) P-Glycoprotein Recognition of Substrates and Circumvention through Rational Drug Design. Molecular Pharmaceutics 3:1, pages 3-25.
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Armin Sturm & Helmut Segner. 2005. Environmental Toxicology. Environmental Toxicology 495 533 .
Kati-Sisko Vellonen, Paavo Honkakoski & Arto Urtti. (2004) Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity. European Journal of Pharmaceutical Sciences 23:2, pages 181-188.
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Ilza Pajeva, Dimiter K. Todorov & Joachim Seydel. (2004) Membrane effects of the antitumor drugs doxorubicin and thaliblastine: comparison to multidrug resistance modulators verapamil and trans-flupentixol. European Journal of Pharmaceutical Sciences 21:2-3, pages 243-250.
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Manuela Ehrhardt, Heike Lindenmaier, Juergen Burhenne, Walter Emil Haefeli & Johanna Weiss. (2004) Influence of lipid lowering fibrates on P-glycoprotein activity in vitro. Biochemical Pharmacology 67:2, pages 285-292.
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William W. Johnson. 2004. Cellular Drug Delivery. Cellular Drug Delivery 129 162 .
Takeo Nakanishi, L. Austin Doyle, Bret Hassel, Yuetong Wei, Kenneth S. Bauer, Suhlan Wu, David W. Pumplin, Hong-Bin Fang & Douglas D. Ross. (2003) Functional Characterization of Human Breast Cancer Resistance Protein (BCRP, ABCG2) Expressed in the Oocytes of Xenopus laevis . Molecular Pharmacology 64:6, pages 1452-1462.
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