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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 3
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Research Article

Disposition of a synthetic analogue of lipid A (E5564) in rats

K. Kaneko Tsukuba Research Laboratories of Eisai Co., Ltd, 5-1-3 Tokodai, Tsukuba-shi, Ibaraki 300-2635, Japan
,
R. Ueda Tsukuba Research Laboratories of Eisai Co., Ltd, 5-1-3 Tokodai, Tsukuba-shi, Ibaraki 300-2635, Japan
,
H. Nemoto Tokai Research Laboratories of Daiichi Pure Chemicals Co., Ltd, 2117 Muramatsu, Tokai-mura, Naka-gun, Ibaraki, 319-1112, Japan
,
H. Iijima Tsukuba Laboratories of Nemoto Science Co., Ltd, 6136-4, Aza Nakamaru, Ohnogoh-machi, Mitsukaidou-shi, Ibaraki, 300-2521, Japan
&
T. Yoshimura Tsukuba Laboratories of Nemoto Science Co., Ltd, 6136-4, Aza Nakamaru, Ohnogoh-machi, Mitsukaidou-shi, Ibaraki, 300-2521, Japan
Pages 323-339 | Published online: 22 Sep 2008

Citations (7)

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Read on this site (3)

Hidetoshi Arima, Yuya Hayashi, Taishi Higashi & Keiichi Motoyama. (2015) Recent advances in cyclodextrin delivery techniques. Expert Opinion on Drug Delivery 12:9, pages 1425-1441.
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Mark Tidswell & Steven P LaRosa. (2011) Toll-like receptor-4 antagonist eritoran tetrasodium for severe sepsis. Expert Review of Anti-infective Therapy 9:5, pages 507-520.
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Amisha Barochia, Steven Solomon, Xizhong Cui, Charles Natanson & Peter Q Eichacker. (2011) Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies. Expert Opinion on Drug Metabolism & Toxicology 7:4, pages 479-494.
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Articles from other publishers (4)

K.A. Shirey, W. Lai, M.C. Patel, L.M. Pletneva, C. Pang, E. Kurt-Jones, M. Lipsky, T. Roger, T. Calandra, K.J. Tracey, Y. Al-Abed, A.G. Bowie, A. Fasano, C.A. Dinarello, F. Gusovsky, J C G Blanco & S.N. Vogel. (2016) Novel strategies for targeting innate immune responses to influenza. Mucosal Immunology 9:5, pages 1173-1182.
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Naoki Aikawa, Yoshio Okubo, Melvyn Lynn, Daniel P Rossignol, Y Nancy Wong, Edgar Schuck, Yasumi Kitahara, Tomohisa Nakano, Olena Sivak, Kishor M Wasan, Christa Nagy & Mark Yen. (2012) Safety, pharmacokinetics and pharmacodynamics of four-hour intravenous infusions of eritoran in healthy Japanese and Caucasian men. Innate Immunity 18:6, pages 793-803.
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Keiichi Motoyama, Hidetoshi Arima, Fumitoshi Hirayama & Kaneto Uekama. (2006) Inhibitory Effects of 2,6-Di-O-methyl-3-O-acetyl-β-cyclodextrins with Various Degrees of Substitution of Acetyl Group on Macrophage Activation and Endotoxin Shock Induced by Lipopolysaccharide. Journal of Inclusion Phenomena and Macrocyclic Chemistry 56:1-2, pages 75-79.
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Kazuhiro Kaneko, Rika Ueda, Tsutomu Kawata, Sally Ishizaka & Tsutomu Yoshimura. (2016) LPS binding protein does not participate in the pharmacokinetics of E5564. Journal of Endotoxin Research 10:3, pages 185-194.
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