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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 7
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Research Article

7-OH-flavone is sulfated in the human liver and duodenum, whereas 5-OH-flavone and 3-OH-flavone are potent inhibitors of SULT1A1 activity and 7-OH-flavone sulfation rate

M. Vietri Department of Neurosciences, Section of Pharmacology, Medical School, Via Roma 55, I-56126 Pisa, Italy
,
A. Pietrabissa Department of Oncology, Section of Surgery, Cisanello Hospital at the University of Pisa, I-56124 Cisanello, Italy
,
R. Spisni Department of Surgery, Via Roma 55, I-56126 Pisa, Italy
,
F. Mosca Department of Neurosciences, Section of Pharmacology, Medical School, Via Roma 55, I-56126 Pisa, Italy
&
G. M. Pacifici Department of Oncology, Section of Surgery, Cisanello Hospital at the University of Pisa, I-56124 Cisanello, Italy
Pages 563-571 | Published online: 22 Sep 2008

Citations (9)

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Read on this site (1)

C. Huang, Y. Chen, T. Zhou & G. Chen. (2009) Sulfation of dietary flavonoids by human sulfotransferases. Xenobiotica 39:4, pages 312-322.
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Articles from other publishers (8)

Robert Ancuceanu, Mihaela Dinu, Cristina Dinu-Pirvu, Valentina Anuţa & Vlad Negulescu. (2019) Pharmacokinetics of B-Ring Unsubstituted Flavones. Pharmaceutics 11:8, pages 370.
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Michael A. van der Horst, Aloysius F. Hartog, Rabab El Morabet, Arthur Marais, Menzo Kircz & Ron Wever. (2015) Enzymatic Sulfation of Phenolic Hydroxy Groups of Various Plant Metabolites by an Arylsulfotransferase. European Journal of Organic Chemistry 2015:3, pages 534-541.
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Hailong Wang, Jin Cao, Shiquan Xu, Daozhao Gu, Yingping Wang & Shengyuan Xiao. (2013) Depletion of high-abundance flavonoids by metal complexation and identification of low-abundance flavonoids in Scutellaria baicalensis Georgi. Journal of Chromatography A 1315, pages 107-117.
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Lan Tang, Qian Feng, Jie Zhao, Lingna Dong, Wei Liu, Caihua Yang & Zhongqiu Liu. (2012) Involvement of UDP-glucuronosyltranferases and sulfotransferases in the liver and intestinal first-pass metabolism of seven flavones in C57 mice and humans in vitro. Food and Chemical Toxicology 50:5, pages 1460-1467.
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Lan Tang, Juan Zhou, Cai-Hua Yang, Bi-Jun Xia, Ming Hu & Zhong-Qiu Liu. (2012) Systematic Studies of Sulfation and Glucuronidation of 12 Flavonoids in the Mouse Liver S9 Fraction Reveal both Unique and Shared Positional Preferences. Journal of Agricultural and Food Chemistry 60:12, pages 3223-3233.
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Stefanie D. Krämer & Bernard Testa. (2009) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 6:10, pages 1477-1660.
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Chi-Sheng Shia, Shang-Yuan Tsai, Sheng-Chu Kuo, Yu-Chi Hou & Pei-Dawn Lee Chao. (2008) Metabolism and Pharmacokinetics of 3,3′,4′,7-Tetrahydroxyflavone (Fisetin), 5-Hydroxyflavone, and 7-Hydroxyflavone and Antihemolysis Effects of Fisetin and Its Serum Metabolites. Journal of Agricultural and Food Chemistry 57:1, pages 83-89.
Crossref
Gian Maria Pacifici. 2005. Human Cytosolic Sulfotransferases. Human Cytosolic Sulfotransferases 157 177 .

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