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Nabi Javadi, Mojtaba Rezaeian & Hossein Fakhraian. (2021) The conglomerate crystal formation of methoxetamine salts in the presence of some organic achiral anions: a theoretical approach. Supramolecular Chemistry 33:5, pages 183-193.
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Bernard Testa. (2015) Types of stereoselectivity in drug metabolism: a heuristic approach. Drug Metabolism Reviews 47:2, pages 239-251.
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M. Karaźniewicz-łada, M. łuczak & F. Główka. (2009) Pharmacokinetic studies of enantiomers of ibuprofen and its chiral metabolites in humans with different variants of genes coding CYP2C8 and CYP2C9 isoenzymes. Xenobiotica 39:6, pages 476-485.
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S. Uno, M. Uraki, H. Komura, H. Ikuta, A. Kawase & M. Iwaki. (2008) Impaired intrinsic chiral inversion activity of ibuprofen in rats with adjuvant-induced arthritis. Xenobiotica 38:11, pages 1410-1421.
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Haiping Hao, Guangji Wang & Jianguo Sun. (2005) Enantioselective Pharmacokinetics of Ibuprofen and Involved Mechanisms. Drug Metabolism Reviews 37:1, pages 215-234.
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Articles from other publishers (58)
Ying Jin, Mengyu Zhang, Xiangjie Di, Xiaohui Qi, Li Zheng & Zhenlei Wang. (2023) Comparison of intravenous ibuprofen pharmacokinetics between Caucasian and Chinese populations using physiologically based pharmacokinetics modeling and simulation. European Journal of Pharmaceutical Sciences 191, pages 106587.
Crossref
Crossref
Justyna Piechocka, Natalia Matwiej, Marta Gaweł, Michał Matyjaszczyk, Rafał Głowacki & Grażyna Chwatko. (2023) Application of the HPLC-ELSD technique for the determination of major metabolites of ibuprofen and creatinine in human urine. Scientific Reports 13:1.
Crossref
Crossref
Wenyan Hua, Wenjia Zhou, Mei Su, Quanying Zhang, Shunlin Zong & Meng Wang. (2023) Comparative Pharmacokinetics and Safety Studies of Dexibuprofen Injection and a Branded Product Ibuprofen Injection in Healthy Chinese Volunteers. Clinical Pharmacology in Drug Development 12:9, pages 881-887.
Crossref
Crossref
Shirong Cao, Yanhua Fu, Bingtong Jiang, Xueli Ge, Qi Wu, Yufan Tao, Pengfei Zhao & Zhaokun Wang. (2023) Simultaneous stereoisomeric separation of loxoprofen sodium and its alcohol metabolites. Application to a stereoselective pharmacokinetic study. Arabian Journal of Chemistry 16:8, pages 104942.
Crossref
Crossref
Dan Xiao, Ying Jin, Mengyu Zhang, Xiangjie Di, Lisha Fu, Changke Jiang, Zhuoli Lai, Yating Ge, Shanmian Ji, Yuming Zhang, Li Zheng, Zhenlei Wang & Fang Gong. (2023) Chiral pharmacokinetics of ibuprofen enantiomers in Chinese preterm neonates with patent ductus arteriosus using a validated UHPLC-MS/MS method. Journal of Chromatography B 1227, pages 123765.
Crossref
Crossref
Valentina I. Merkus, Christina Sommer, Esther Smollich, Bernd Sures & Torsten C. Schmidt. (2022) Acute ecotoxicological effects on daphnids and green algae caused by the ozonation of ibuprofen. Science of The Total Environment 847, pages 157611.
Crossref
Crossref
V. V. S. Prasanna Kumari Rayala, Jony Susanna Kandula & Radhakrishnanand P. (2022) Advances and challenges in the pharmacokinetics and bioanalysis of chiral drugs. Chirality 34:10, pages 1298-1310.
Crossref
Crossref
Noémi-Piroska KovácsAttila AlmásiKitti GaraiMónika KuzmaSzende VanceaEmil FischerPál Perjési. (2019) Investigation of intestinal elimination and biliary excretion of ibuprofen in hyperglycemic rats. Canadian Journal of Physiology and Pharmacology 97:11, pages 1080-1089.
Crossref
Crossref
Emilia Waraksa, Mateusz Kacper Woźniak, Laura Banaszkiewicz, Ewa Kłodzińska, Mariusz Ozimek, Robert Wrzesień, Barbara Bobrowska-Korczak & Jacek Namieśnik. (2019) Quantification of unconjugated and total ibuprofen and its metabolites in equine urine samples by gas chromatography–tandem mass spectrometry: Application to the excretion study. Microchemical Journal 150, pages 104129.
Crossref
Crossref
Aleksandra Kapedanovska Nestorovska, Krume Jakjovski, Zorica Naumovska, Zoran Sterjev, Nadica Matevska Geskovska, Kristina Mladenovska, Ljubica Suturkova & Aleksandar Dimovski. (2019) AKR1D1*36 C>T (rs1872930) allelic variant is associated with variability of the CYP2C9 genotype predicted pharmacokinetics of ibuprofen enantiomers – a pilot study in healthy volunteers. Acta Pharmaceutica 69:3, pages 399-412.
Crossref
Crossref
Joske Millecam, Siegrid De Baere, Siska Croubels & Mathias Devreese. (2019) In Vivo Metabolism of Ibuprofen in Growing Conventional Pigs: A Pharmacokinetic Approach. Frontiers in Pharmacology 10.
Crossref
Crossref
Takaaki Matsumoto, Maho Sato, Wataru Yamazaki, Shoujiro Ogawa & Tatsuya Higashi. (2019) (S)-1-(1-Methylpyridin-2-yl)-3-aminopiperidine as a novel derivatization reagent capable of enantiomeric separation and enhanced ESI-MS/MS detection for chiral carboxylic acids. Microchemical Journal 146, pages 25-33.
Crossref
Crossref
Emilia Waraksa, Marzena Wójtowicz-Zawadka, Dorota Kwiatkowska, Anna Jarek, Anna Małkowska, Robert Wrzesień & Jacek Namieśnik. (2018) Simultaneous determination of ibuprofen and its metabolites in complex equine urine matrices by GC-EI-MS in excretion study in view of doping control. Journal of Pharmaceutical and Biomedical Analysis 152, pages 279-288.
Crossref
Crossref
Lu-Ping Li, Mei-Na Jin, Qing Shi, Chun-Yan Xu, Ying-Zi Jiang, Yong-Ill Lee & Jun Zhe Min. (2017) Synthesis and evaluation of a novel chiral derivatization reagent for resolution of carboxylic acid enantiomers by RP-HPLC. Microchemical Journal 135, pages 213-220.
Crossref
Crossref
Koji Chiba, Keiko Shimizu, Motohiro Kato, Taichi Miyazaki, Takaaki Nishibayashi, Kazuki Terada & Yuichi Sugiyama. (2017) Estimation of Interindividual Variability of Pharmacokinetics of CYP2C9 Substrates in Humans. Journal of Pharmaceutical Sciences 106:9, pages 2695-2703.
Crossref
Crossref
Hiroyuki Ikuta, Atsushi Kawase & Masahiro Iwaki. (2017) Stereoselective Pharmacokinetics and Chiral Inversion of Ibuprofen in Adjuvant-induced Arthritic Rats. Drug Metabolism and Disposition 45:3, pages 316-324.
Crossref
Crossref
Qili Zhang, Danlin Wang, Meiyan Zhang, Yunli Zhao & Zhiguo Yu. (2017) The determination of 2-(2-hydroxypropanamido) benzoic acid enantiomers and their corresponding prodrugs in rat plasma by UHPLC–MS/MS and application to comparative pharmacokinetic study after a single oral dose. Journal of Chromatography B 1041-1042, pages 175-182.
Crossref
Crossref
A González-Mira, I Varó, M Solé & A Torreblanca. (2016) Drugs of environmental concern modify Solea senegalensis physiology and biochemistry in a temperature-dependent manner. Environmental Science and Pollution Research 23:20, pages 20937-20951.
Crossref
Crossref
Carsten Uhd Nielsen, Rune N. Rasmussen, Junying Mo, Benafsha Noori, Candela Lagunas, René Holm & Martha K. Nøhr. (2016) A Transporter of Ibuprofen is Upregulated in MDCK I Cells under Hyperosmotic Culture Conditions. Molecular Pharmaceutics 13:9, pages 3119-3129.
Crossref
Crossref
Fakhreddin Jamali & Dion R. Brocks. 2015. Ibuprofen. Ibuprofen
81
131
.
Kenneth J. Nichol & David W. Allen. 2015. Ibuprofen. Ibuprofen
22
50
.
Eugen F. Mesaros, Thelma S. Angeles, Mark S. Albom, Jason C. Wagner, Lisa D. Aimone, Weihua Wan, Lihui Lu, Zeqi Huang, Mark Olsen, Emily Kordwitz, R. Curtis Haltiwanger, Amy J. Landis, Mangeng Cheng, Bruce A. Ruggeri, Mark A. Ator, Bruce D. Dorsey & Gregory R. Ott. (2015) Piperidine-3,4-diol and piperidine-3-ol derivatives of pyrrolo[2,1-f][1,2,4]triazine as inhibitors of anaplastic lymphoma kinase. Bioorganic & Medicinal Chemistry Letters 25:5, pages 1047-1052.
Crossref
Crossref
Ismail I. Hewala, Marwa S. Moneeb, Hatem A. Elmongy & Abdel-Aziz M. Wahbi. (2014) Enantioselective HPLC-DAD method for the determination of etodolac enantiomers in tablets, human plasma and application to comparative pharmacokinetic study of both enantiomers after a single oral dose to twelve healthy volunteers. Talanta 130, pages 506-517.
Crossref
Crossref
Shoujiro Ogawa, Hiroaki Tadokoro, Maho Sato & Tatsuya Higashi. (2014) Enantioselective determination of ibuprofen in saliva by liquid chromatography/tandem mass spectrometry with chiral electrospray ionization-enhancing and stable isotope-coded derivatization. Journal of Pharmaceutical and Biomedical Analysis 98, pages 387-392.
Crossref
Crossref
Jessica Karlsson & Christopher J. Fowler. (2014) Inhibition of Endocannabinoid Metabolism by the Metabolites of Ibuprofen and Flurbiprofen. PLoS ONE 9:7, pages e103589.
Crossref
Crossref
Juciane Lauren Cavalcanti Cardoso, Vera Lucia Lanchote, Maria Paula Marques Pereira, Natália Valadares de Moraes & José Salvador Lepera. (2014) Analysis of ibuprofen enantiomers in rat plasma by liquid chromatography with tandem mass spectrometry. Journal of Separation Science 37:8, pages 944-949.
Crossref
Crossref
Ibtihal Q. Abdulla. (2014) Synthesis and antimicrobial activity of Ibuprofen derivatives. Natural Science 06:02, pages 47-53.
Crossref
Crossref
Shoujiro Ogawa, Hiroaki Tadokoro, Maho Sato, Takehisa Hanawa & Tatsuya Higashi. (2013) (S)-1-(4-Dimethylaminophenylcarbonyl)-3-aminopyrrolidine: A derivatization reagent for enantiomeric separation and sensitive detection of chiral carboxylic acids by LC/ESI-MS/MS. Journal of Chromatography B 940, pages 7-14.
Crossref
Crossref
Jenny-Maria Brozinski, Marja Lahti, Aimo Oikari & Leif Kronberg. (2013) Identification and dose dependency of ibuprofen biliary metabolites in rainbow trout. Chemosphere 93:9, pages 1789-1795.
Crossref
Crossref
Kristin A. Connors, Bowen Du, Patrick N. Fitzsimmons, C. Kevin Chambliss, John W. Nichols & Bryan W. Brooks. (2013)
Enantiomer‐Specific In Vitro Biotransformation of Select Pharmaceuticals in Rainbow Trout (
Oncorhynchus mykiss
)
. Chirality 25:11, pages 763-767.
Crossref
Crossref
Bernard Testa. (2013) Organic Stereochemistry. Part 8. Helvetica Chimica Acta 96:8, pages 1409-1451.
Crossref
Crossref
Mark P. Grillo, Michelle Tadano Lohr & Smriti Khera. (2013)
Interaction of
γ
-Glutamyltranspeptidase with Ibuprofen-
S
-Acyl-Glutathione In Vitro and In Vivo in Human
. Drug Metabolism and Disposition 41:1, pages 111-121.
Crossref
Crossref
Cathy Boscarino, Andrea N. Edginton, Henry Peng, K. Wayne Riggs, András Szeitz & Bob Cheung. (2012) The effect of operational stressors on ibuprofen pharmacokinetics. European Journal of Clinical Pharmacology 69:1, pages 31-41.
Crossref
Crossref
Míriam Pérez-Trujillo, John C. LindonTeodor Parella, Hector C. KeunJeremy K. NicholsonToby J. Athersuch. (2012)
Chiral Metabonomics:
1
H NMR-Based Enantiospecific Differentiation of Metabolites in Human Urine via Direct Cosolvation with β-Cyclodextrin
. Analytical Chemistry 84:6, pages 2868-2874.
Crossref
Crossref
Tomasz Grabowski, Jerzy Jan Jaroszewski, Shayne Cox Gad & Marcin Feder. (2012) Correlation Between In Silico Physicochemical Characteristics of Drugs and Their Mean Residence Time in Human and Dog. International Journal of Toxicology 31:1, pages 25-33.
Crossref
Crossref
Daniela Buchheit, Călin-Aurel Drăgan, Ellen I. Schmitt & Matthias Bureik. (2011) Production of Ibuprofen Acyl Glucosides by Human UGT2B7. Drug Metabolism and Disposition 39:12, pages 2174-2181.
Crossref
Crossref
T.B. Adams, C. Lucas Gavin, M.M. McGowen, W.J. Waddell, S.M. Cohen, V.J. Feron, L.J. Marnett, I.C. Munro, P.S. Portoghese, I.M.C.M. Rietjens & R.L. Smith. (2011) The FEMA GRAS assessment of aliphatic and aromatic terpene hydrocarbons used as flavor ingredients. Food and Chemical Toxicology 49:10, pages 2471-2494.
Crossref
Crossref
Haina Wang, Jianbo Ji & Su Zeng. (2011) Biosynthesis and stereoselective analysis of (−)- and (+)-zaltoprofen glucuronide in rat hepatic microsomes and its application to the kinetic analysis. Journal of Chromatography B 879:24, pages 2430-2436.
Crossref
Crossref
Kosuke Doki, Toru Hayakawa, Wenhui Lin, Hitomi Yanaguimoto, Guohua Ding & Nobuo Inotsume. (2003) Effects of absorption rate on the pre-systemic chiral inversion of ibuprofen in rabbits. Journal of Pharmacy and Pharmacology 55:8, pages 1091-1097.
Crossref
Crossref
András Szeitz, Andrea Nicole Edginton, Henry Tao Peng, Bob Cheung & Kenneth Wayne Riggs. (2010) A Validated Enantioselective Assay for the Determination of Ibuprofen in Human Plasma Using Ultra Performance Liquid Chromatography with Tandem Mass Spectrometry (UPLC-MS/MS). American Journal of Analytical Chemistry 01:02, pages 47-58.
Crossref
Crossref
Bernard Testa & Stefanie D. Krämer. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:11, pages 2171-2336.
Crossref
Crossref
Derek J. CrockfordAnthony D. MaherKourosh R. AhmadiAmy BarrettRobert S. PlumbIan D. WilsonJeremy K. Nicholson. (2008)
1
H NMR and UPLC-MS
E
Statistical Heterospectroscopy: Characterization of Drug Metabolites (Xenometabolome) in Epidemiological Studies
. Analytical Chemistry 80:18, pages 6835-6844.
Crossref
Crossref
Eric L. Kendig, Scott N. Schneider, Deborah J. Clegg, Mary Beth Genter & Howard G. Shertzer. (2008) Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet. Biochemical Pharmacology 76:2, pages 216-224.
Crossref
Crossref
Chaonan Zheng, Haiping Hao, Guangji Wang, Guowei Sang, Jianguo Sun, Peng Li & Jing Li. (2008) Chiral separation of ibuprofen and chiral pharmacokinetics in healthy chinese volunteers. European Journal of Drug Metabolism and Pharmacokinetics 33:1, pages 45-51.
Crossref
Crossref
Franciszek Główka & Marta Karaźniewicz. (2007) Enantioselective CE method for pharmacokinetic studies on ibuprofen and its chiral metabolites with reference to genetic polymorphism. ELECTROPHORESIS 28:15, pages 2726-2737.
Crossref
Crossref
Aleksi Tornio, Mikko Niemi, Pertti J. Neuvonen & Janne T. Backman. (2007) Stereoselective interaction between the CYP2C8 inhibitor gemfibrozil and racemic ibuprofen. European Journal of Clinical Pharmacology 63:5, pages 463-469.
Crossref
Crossref
Nicholas Moore. (2007) Diclofenac Potassium 12.5mg Tablets for Mild to Moderate Pain and Fever. Clinical Drug Investigation 27:3, pages 163-195.
Crossref
Crossref
Stephen J. Vanderhoeven, John C. Lindon, Jeff Troke, Jeremy K. Nicholson & Ian D. Wilson. (2006) NMR spectroscopic studies of the transacylation reactivity of ibuprofen 1-β-O-acyl glucuronide. Journal of Pharmaceutical and Biomedical Analysis 41:3, pages 1002-1006.
Crossref
Crossref
H. Potthast, J.B. Dressman, H.E. Junginger, K.K. Midha, H. Oeser, V.P. Shah, H. Vogelpoel & D.M. Barends. (2005) Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ibuprofen**This paper reflects the scientific opinion of the authors and not the policies of regulating agencies.. Journal of Pharmaceutical Sciences 94:10, pages 2121-2131.
Crossref
Crossref
Anderson Rodrigo Moraes de Oliveira, Fernando José Malagueño de Santana & Pierina Sueli Bonato. (2005) Stereoselective determination of the major ibuprofen metabolites in human urine by off-line coupling solid-phase microextraction and high-performance liquid chromatography. Analytica Chimica Acta 538:1-2, pages 25-34.
Crossref
Crossref
Franciszek K. Główka & Marta Karaźniewicz. (2005) High performance capillary electrophoresis method for determination of ibuprofen enantiomers in human serum and urine. Analytica Chimica Acta 540:1, pages 95-102.
Crossref
Crossref
Nicole Sabolovic, Jean-Marie Heydel, Xin Li, Joanna M. Little, Anne-Claude Humbert, Anna Radominska-Pandya & Jacques Magdalou. (2004) Carboxyl nonsteroidal anti-inflammatory drugs are efficiently glucuronidated by microsomes of the human gastrointestinal tract. Biochimica et Biophysica Acta (BBA) - General Subjects 1675:1-3, pages 120-129.
Crossref
Crossref
Marc Lindenberg, Sabine Kopp & Jennifer B Dressman. (2004) Classification of orally administered drugs on the World Health Organization Model list of Essential Medicines according to the biopharmaceutics classification system. European Journal of Pharmaceutics and Biopharmaceutics 58:2, pages 265-278.
Crossref
Crossref
Elka Touitou, Biana Godin, Thirumala Kommuru, Mohsen Afouna & Indra Reddy. 2004. Chirality in Drug Design and Development. Chirality in Drug Design and Development.
Emily E Han, Paul M Beringer, Stan G Louie, Mark A Gill & Bertrand J Shapiro. (2004) Pharmacokinetics of Ibuprofen in Children with Cystic Fibrosis. Clinical Pharmacokinetics 43:3, pages 145-156.
Crossref
Crossref
Pierina Sueli Bonato, Maria Perpetua F.M Del Lama & Roberto de Carvalho. (2003) Enantioselective determination of ibuprofen in plasma by high-performance liquid chromatography–electrospray mass spectrometry. Journal of Chromatography B 796:2, pages 413-420.
Crossref
Crossref
Soo Choon Tan, Bhavesh K. Patel, Stephen H. D. Jackson, Cameron G. Swift & Andrew J. Hutt. (2003) Influence of age on the enantiomeric disposition of ibuprofen in healthy volunteers. British Journal of Clinical Pharmacology 55:6, pages 579-587.
Crossref
Crossref
Steve K. Teo, Yong Chen, George W. Muller, Roger S. Chen, Steve D. Thomas, David I. Stirling & Reddy S. Chandula. (2003) Chiral inversion of the second generation IMiD™ CC‐4047 (ACTIMID™) in human plasma and phosphate‐buffered saline. Chirality 15:4, pages 348-351.
Crossref
Crossref