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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 8
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Research Article

Pharmacokinetics and metabolism of the anti-oestrogen droloxifene in female human subjects

B. A. John Department of Metabolism and Pharmacokinetics, Huntingdon Life Sciences, Huntingdon PE28 4HS, UK
,
R. R. Brodie Klinge Pharma GmbH, 81673, Munich, Germany
,
G. A. Baldock Department of Metabolism and Pharmacokinetics, Huntingdon Life Sciences, Huntingdon PE28 4HS, UK
,
A. McBurney Klinge Pharma GmbH, 81673, Munich, Germany
,
L. F. Chasseaud Department of Metabolism and Pharmacokinetics, Huntingdon Life Sciences, Huntingdon PE28 4HS, UK
,
P. Jank Klinge Pharma GmbH, 81673, Munich, Germany
&
A. von Nieciecki Department of Metabolism and Pharmacokinetics, Huntingdon Life Sciences, Huntingdon PE28 4HS, UK
 show all
Pages 699-713 | Published online: 22 Sep 2008

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Dennis A. Smith & Deepak Dalvie. (2012) Why do metabolites circulate?. Xenobiotica 42:1, pages 107-126.
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Articles from other publishers (10)

Muzna Ali Khattak, Zafar Iqbal, Nasir Fazli, Fahim Ullah Khan, SumairaIrum Khan, Shazma Gohar, Mirina Sakhi, Muhammad Iqbal & Sadia Pervez. (2022) Using the Design of Experiments for Development, Validation, and Optimization of HPLC-UV Assay of Tamoxifen Citrate in Polymeric Nanoparticles. Pharmaceutical Chemistry Journal 56:9, pages 1297-1306.
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Shuai Huang, Hui Wang, Wei Chen, Ming Zhan, Sunwang Xu, Xince Huang, Ruirong Lin, Hui Shen & Jian Wang. (2019) Tamoxifen inhibits cell proliferation by impaired glucose metabolism in gallbladder cancer. Journal of Cellular and Molecular Medicine 24:2, pages 1599-1613.
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Hadir M. Maher, Nourah Z. Alzoman & Shereen M. Shehata. (2016) Simultaneous determination of erlotinib and tamoxifen in rat plasma using UPLC–MS/MS: Application to pharmacokinetic interaction studies. Journal of Chromatography B 1028, pages 100-110.
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Marina Venzon Antunes, Daniela Dornelles Rosa, Tamyris dos Santos Viana, Huander Andreolla, Tiago Ozelame Fontanive & Rafael Linden. (2013) Sensitive HPLC–PDA determination of tamoxifen and its metabolites N-desmethyltamoxifen, 4-hydroxytamoxifen and endoxifen in human plasma. Journal of Pharmaceutical and Biomedical Analysis 76, pages 13-20.
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S.F. Teunissen, H. Rosing, M. Dominguez Seoane, L. Brunsveld, J.H.M. Schellens, A.H. Schinkel & J.H. Beijnen. (2011) Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques. Journal of Pharmaceutical and Biomedical Analysis 55:3, pages 518-526.
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S.F. Teunissen, H. Rosing, A.H. Schinkel, J.H.M. Schellens & J.H. Beijnen. (2010) Bioanalytical methods for determination of tamoxifen and its phase I metabolites: A review. Analytica Chimica Acta 683:1, pages 21-37.
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Deepak Dalvie, R. Scott Obach, Ping Kang, Chandra Prakash, Cho-Ming Loi, Susan Hurst, Angus Nedderman, Lance Goulet, Evan Smith, Hai-Zhi Bu & Dennis A. Smith. (2009) Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites. Chemical Research in Toxicology 22:2, pages 357-368.
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Wendy Shelly, Michael W. Draper, Venkatesh Krishnan, Mayme Wong & Robert B. Jaffe. (2008) Selective Estrogen Receptor Modulators: An Update on Recent Clinical Findings. Obstetrical & Gynecological Survey 63:3, pages 163-181.
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Priyanka Parte & David Kupfer. (2005) OXIDATION OF TAMOXIFEN BY HUMAN FLAVIN-CONTAINING MONOOXYGENASE (FMO) 1 AND FMO3 TO TAMOXIFEN- N -OXIDE AND ITS NOVEL REDUCTION BACK TO TAMOXIFEN BY HUMAN CYTOCHROMES P450 AND HEMOGLOBIN . Drug Metabolism and Disposition 33:10, pages 1446-1452.
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Tony Antoniou & Alice L Tseng. (2005) Interactions Between Antiretrovirals and Antineoplastic Drug Therapy. Clinical Pharmacokinetics 44:2, pages 111-145.
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