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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 8
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Research Article

Permissive and suppressive effects of dexamethasone on enzyme induction in hepatocyte co-cultures

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Pages 653-666 | Published online: 22 Sep 2008

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Poonam Giri, Prashant Delvadia, Laxmikant Gupta, Nirmal Patel, Priyal Trivedi, Krishna Lad, Hiren M. Patel & Nuggehally R. Srinivas. (2018) Consequences of daily corticosteroid dosing with or without pre-treatment with quinidine on the in vivo cytochrome P450 2D (CYP2D) enzyme in rats: effect on O-demethylation activity of dextromethorphan and expression levels of CYP2D1 mRNA. Xenobiotica 48:1, pages 1-10.
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Nicola J. Hewitt, María José Gómez Lechón, J. Brian Houston, David Hallifax, Hayley S. Brown, Patrick Maurel, J. Gerald Kenna, Lena Gustavsson, Christina Lohmann, Christian Skonberg, Andre Guillouzo, Gregor Tuschl, Albert P. Li, Edward LeCluyse, Geny M. M. Groothuis & Jan G. Hengstler. (2007) Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies. Drug Metabolism Reviews 39:1, pages 159-234.
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Jan G Hengstler, Marc Brulport, Wiebke Schormann, Alexander Bauer, Matthias Hermes, Andreas K Nussler, Fred Fandrich, Maren Ruhnke, Hendrik Ungefroren, Louise Griffin, Ernesto Bockamp, Franz Oesch & Marc-Alexander von Mach. (2005) Generation of human hepatocytes by stem cell technology: definition of the hepatocyte. Expert Opinion on Drug Metabolism & Toxicology 1:1, pages 61-74.
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Rolf Gebhardt, Jan G. Hengstler, Dieter Müller, Reinhild Glöckner, Peter Buenning, Britta Laube, Eva Schmelzer, Martina Ullrich, Dietmar Utesch, Nicola Hewitt, Michael Ringel, Beate Reder Hilz, Augustinus Bader, Angelika Langsch, Thomas Koose, Hans-Jörg Burger, Jochen Maas & Franz Oesch. (2003) New Hepatocyte In Vitro Systems for Drug Metabolism: Metabolic Capacity and Recommendations for Application in Basic Research and Drug Development, Standard Operation Procedures. Drug Metabolism Reviews 35:2-3, pages 145-213.
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Articles from other publishers (20)

M. Farooq, E. J. Kelly & J. D. Unadkat. (2016) CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids. Drug Metabolism and Disposition 44:5, pages 750-757.
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Viktoriia Burkina, Sidika Sakalli, Martin Krøyer Rasmussen, Galia Zamaratskaia, Olga Koba, Giang Pham Thai, Roman Grabic, Tomas Randak & Vladimir Zlabek. (2015) Does dexamethasone affect hepatic CYP450 system of fish? Semi-static in-vivo experiment on juvenile rainbow trout. Chemosphere 139, pages 155-162.
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Viktoriia Burkina, Vladimir Zlabek & Galia Zamaratskaia. (2013) Clotrimazole, but not dexamethasone, is a potent in vitro inhibitor of cytochrome P450 isoforms CYP1A and CYP3A in rainbow trout. Chemosphere 92:9, pages 1099-1104.
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Patricio Godoy, Nicola J. Hewitt, Ute Albrecht, Melvin E. Andersen, Nariman Ansari, Sudin Bhattacharya, Johannes Georg Bode, Jennifer Bolleyn, Christoph Borner, Jan Böttger, Albert Braeuning, Robert A. Budinsky, Britta Burkhardt, Neil R. Cameron, Giovanni Camussi, Chong-Su Cho, Yun-Jaie Choi, J. Craig Rowlands, Uta Dahmen, Georg Damm, Olaf Dirsch, María Teresa Donato, Jian Dong, Steven Dooley, Dirk Drasdo, Rowena Eakins, Karine Sá Ferreira, Valentina Fonsato, Joanna Fraczek, Rolf Gebhardt, Andrew Gibson, Matthias Glanemann, Chris E. P. Goldring, María José Gómez-Lechón, Geny M. M. Groothuis, Lena Gustavsson, Christelle Guyot, David Hallifax, Seddik Hammad, Adam Hayward, Dieter Häussinger, Claus Hellerbrand, Philip Hewitt, Stefan Hoehme, Hermann-Georg Holzhütter, J. Brian Houston, Jens Hrach, Kiyomi Ito, Hartmut Jaeschke, Verena Keitel, Jens M. Kelm, B. Kevin Park, Claus Kordes, Gerd A. Kullak-Ublick, Edward L. LeCluyse, Peng Lu, Jennifer Luebke-Wheeler, Anna Lutz, Daniel J. Maltman, Madlen Matz-Soja, Patrick McMullen, Irmgard Merfort, Simon Messner, Christoph Meyer, Jessica Mwinyi, Dean J. Naisbitt, Andreas K. Nussler, Peter Olinga, Francesco Pampaloni, Jingbo Pi, Linda Pluta, Stefan A. Przyborski, Anup Ramachandran, Vera Rogiers, Cliff Rowe, Celine Schelcher, Kathrin Schmich, Michael Schwarz, Bijay Singh, Ernst H. K. Stelzer, Bruno Stieger, Regina Stöber, Yuichi Sugiyama, Ciro Tetta, Wolfgang E. Thasler, Tamara Vanhaecke, Mathieu Vinken, Thomas S. Weiss, Agata Widera, Courtney G. Woods, Jinghai James Xu, Kathy M. Yarborough & Jan G. Hengstler. (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Archives of Toxicology 87:8, pages 1315-1530.
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María José Gómez-Lechón, José V. Castell & María Teresa Donato. 2010. Hepatocytes. Hepatocytes 389 415 .
J. G. Hengstler, P. Godoy & H. M. Bolt. (2009) The dilemma of cultivated hepatocytes. Archives of Toxicology 83:2, pages 101-103.
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Andreas K. Nussler, Natascha C. Nussler, Vera Merk, Marc Brulport, Wiebke Schormann, Ping Yao & Jan G. Hengstler. 2009. Strategies in Regenerative Medicine. Strategies in Regenerative Medicine 1 38 .
Esther G. van de Kerkhof, Inge A. M. de Graaf, Anna-Lena B. Ungell & Geny M. M. Groothuis. (2008) Induction of Metabolism and Transport in Human Intestine: Validation of Precision-Cut Slices as a Tool to Study Induction of Drug Metabolism in Human Intestine in Vitro. Drug Metabolism and Disposition 36:3, pages 604-613.
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Gerhard Friedrich, Thorsten Rose, Alexander Wawkuschewski, Sabine Kafert-Kasting, Britta Laube, Lubomir Arseniev & Klaus Rissler. (2007) Determination of Testosterone Metabolites in Rat Hepatocytes with and without Cryopreservation by On-Line SPE Column-Switching LC and MS Detection. Chromatographia 67:1-2, pages 31-39.
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Priscilla L.K. Lim, Weiqi Tan, Calivarathan Latchoumycandane, Wei Chuen Mok, Yok Moi Khoo, How Sung Lee, Jetsumon Sattabongkot, Walter Beerheide, Seng Gee Lim, Theresa M.C. Tan & Urs A. Boelsterli. (2007) Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously immortalized human hepatocyte line HC-04. Toxicology in Vitro 21:8, pages 1390-1401.
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E. G. van de Kerkhof, I. A. M. de Graaf, M. H. de Jager & G. M. M. Groothuis. (2007) Induction of Phase I and II Drug Metabolism in Rat Small Intestine and Colon in Vitro. Drug Metabolism and Disposition 35:6, pages 898-907.
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Nicola J. Hewitt, Ruben de Kanter & Edward LeCluyse. (2007) Induction of drug metabolizing enzymes: A survey of in vitro methodologies and interpretations used in the pharmaceutical industry—Do they comply with FDA recommendations?. Chemico-Biological Interactions 168:1, pages 51-65.
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Diane L. Nabb, Robert T. Mingoia, Ching-Hui Yang & Xing Han. (2006) Comparison of basal level metabolic enzyme activities of freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat. Aquatic Toxicology 80:1, pages 52-59.
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M. Dacasto, C. Montesissa & C. Nebbia. (2006) Illegal Drug Treatments and Drug Metabolism: Biomarkers or Not?. Veterinary Research Communications 30:S1, pages 113-119.
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Sabine Kafert-Kasting, Krassimira Alexandrova, Marc Barthold, Britta Laube, Gerhard Friedrich, Lubomir Arseniev & Jan G. Hengstler. (2006) Enzyme induction in cryopreserved human hepatocyte cultures. Toxicology 220:2-3, pages 117-125.
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Kewei Zhang, Masanori Kuroha, Yuko Shibata, Eiichi Kokue & Minoru Shimoda. (2006) Effect of oral administration of clinically relevant doses of dexamethasone on regulation of cytochrome P450 subfamilies in hepatic microsomes from dogs and rats. American Journal of Veterinary Research 67:2, pages 329-334.
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Maren Ruhnke, Andreas K. Nussler, Hendrik Ungefroren, Jan G. Hengstler, Bernd Kremer, Wolfgang Hoeckh, Thomas Gottwald, Peter Heeckt & Fred Fandrich. (2005) Human Monocyte-Derived Neohepatocytes: A Promising Alternative to Primary Human Hepatocytes for Autologous Cell Therapy. Transplantation 79:9, pages 1097-1103.
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Katalin Monostory, Krisztina Kőhalmy, Russell A. Prough, László Kóbori & László Vereczkey. (2005) The effect of synthetic glucocorticoid, dexamethasone on CYP1A1 inducibility in adult rat and human hepatocytes. FEBS Letters 579:1, pages 229-235.
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M. Ringel, M.A. von Mach, R. Santos, P.J. Feilen, M. Brulport, M. Hermes, A.W. Bauer, W. Schormann, B. Tanner, M.R. Sch?n, F. Oesch & J.G. Hengstler. (2005) Hepatocytes cultured in alginate microspheres: an optimized technique to study enzyme induction. Toxicology 206:1, pages 153-167.
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Helena Carmo, Jan G. Hengstler, Douwe de Boer, Michael Ringel, Fernando Remião, Félix Carvalho, Eduarda Fernandes, Lesseps A. dos Reys, Franz Oesch & Maria de Lourdes Bastos. (2005) Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human. Toxicology 206:1, pages 75-89.
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