Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 8
542
Views
44
CrossRef citations to date
0
Altmetric
Research Article

Pharmacokinetics and disposition of rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in rat

, , , , &
Pages 715-727 | Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

Mingxiang Liao, Qing Zhu, Andy Zhu, Christopher Gemski, Bingli Ma, Emily Guan, Albert P. Li, Guangqing Xiao & Cindy Q. Xia. (2019) Comparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans. Xenobiotica 49:7, pages 852-862.
Read now
Xin Zhou, Fangrong Zhang, Chang Chen, Zitao Guo, Jia Liu, Jinghua Yu, Yong Xu, Dafang Zhong & Hongliang Jiang. (2017) Impact of curcumin on the pharmacokinetics of rosuvastatin in rats and dogs based on the conjugated metabolites. Xenobiotica 47:3, pages 267-275.
Read now
Liyue Huang, April Chen, John Roberts, Brett Janosky, Xuhai Be, Loren Berry & Min-Hwa Jasmine Lin. (2012) Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds. Xenobiotica 42:9, pages 830-840.
Read now
Alice Zachařová, Michal Šiller, Alena Špičáková, Eva Anzenbacherová, Nina Škottová, Pavel Anzenbacher & Rostislav Večeřa. (2012) Rosuvastatin suppresses the liver microsomal CYP2C11 and CYP2C6 expression in male Wistar rats. Xenobiotica 42:8, pages 731-736.
Read now
Orianne Videau, Sylvain Pitarque, Sylvie Troncale, Patrick Hery, Etienne Thévenot, Marcel Delaforge & Henri Bénech. (2012) Can a cocktail designed for phenotyping pharmacokinetics and metabolism enzymes in human be used efficiently in rat?. Xenobiotica 42:4, pages 349-354.
Read now
Federico Colombo, Catherine Armstrong, Jianmin Duan & Nathalie Rioux. (2012) A high throughput in vitro mrp2 assay to predict in vivo biliary excretion. Xenobiotica 42:2, pages 157-163.
Read now
H. Fujino, T. Saito, Y. Tsunenari, J. Kojima & T. Sakaeda. (2004) Metabolic properties of the acid and lactone forms of HMG-CoA reductase inhibitors. Xenobiotica 34:11-12, pages 961-971.
Read now
Harold Bays & Evan A Stein. (2003) Pharmacotherapy for dyslipidaemia – current therapies and future agents. Expert Opinion on Pharmacotherapy 4:11, pages 1901-1938.
Read now
Harold Bays & Carlos Dujovne. (2003) Colesevelam HCl: a non-systemic lipidaltering drug. Expert Opinion on Pharmacotherapy 4:5, pages 779-790.
Read now
K. Nezasa, K. Higaki, M. Takeuchi, M. Nakano & M. Koike. (2003) Uptake of rosuvastatin by isolated rat hepatocytes: comparison with pravastatin. Xenobiotica 33:4, pages 379-388.
Read now

Articles from other publishers (33)

Yubin Song, Hee-Hyun Lim, Jeong Yee, Ha-Young Yoon & Hye-Sun Gwak. (2022) The Association between ABCG2 421C>A (rs2231142) Polymorphism and Rosuvastatin Pharmacokinetics: A Systematic Review and Meta-Analysis. Pharmaceutics 14:3, pages 501.
Crossref
Chen Ning, Shengdi Su, Jiaming Li, Dexuan Kong, Hui Cai, Zhiying Qin, Han Xing, Xijing Chen & Jiake He. (2021) Evaluation of a Clinically Relevant Drug–Drug Interaction Between Rosuvastatin and Clopidogrel and the Risk of Hepatotoxicity. Frontiers in Pharmacology 12.
Crossref
Christine M. Bowman, Fang Ma, Jialin Mao & Yuan Chen. (2020) Examination of Physiologically‐Based Pharmacokinetic Models of Rosuvastatin. CPT: Pharmacometrics & Systems Pharmacology 10:1, pages 5-17.
Crossref
Lei Tian, Li Xu, Jian Li & Mei He. (2020) Synthesis of deuterium-labeled rosuvastatin calcium. Journal of Radioanalytical and Nuclear Chemistry 324:3, pages 941-947.
Crossref
Kazuya Ishida, Mohammed Ullah, Beáta Tóth, Viktoria Juhasz & Jashvant D. Unadkat. (2018) Successful Prediction of In Vivo Hepatobiliary Clearances and Hepatic Concentrations of Rosuvastatin Using Sandwich-Cultured Rat Hepatocytes, Transporter-Expressing Cell Lines, and Quantitative Proteomics. Drug Metabolism and Disposition 46:1, pages 66-74.
Crossref
Takashi Yoshikado, Kota Toshimoto, Tomohisa Nakada, Kazuaki Ikejiri, Hiroyuki Kusuhara, Kazuya Maeda & Yuichi Sugiyama. (2017) Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins. Drug Metabolism and Disposition 45:7, pages 779-789.
Crossref
Ari Hashimoto, Tsukasa Oikawa, Shigeru Hashimoto, Hirokazu Sugino, Ayumu Yoshikawa, Yutaro Otsuka, Haruka Handa, Yasuhito Onodera, Jin-Min Nam, Chitose Oneyama, Masato Okada, Mitsunori Fukuda & Hisataka Sabe. (2016) P53- and mevalonate pathway–driven malignancies require Arf6 for metastasis and drug resistance. Journal of Cell Biology 213:1, pages 81-95.
Crossref
Tsuyoshi Mikkaichi, Daisuke Nakai, Yasushi Yoshigae, Tomoki Imaoka, Noriko Okudaira & Takashi Izumi. (2015) Liver-selective distribution in rats supports the importance of active uptake into the liver via organic anion transporting polypeptides (OATPs) in humans. Drug Metabolism and Pharmacokinetics 30:5, pages 334-340.
Crossref
H. Shen, H. Su, T. Liu, M. Yao, G. Mintier, L. Li, R. M. Fancher, R. Iyer, P. Marathe, Y. Lai & A. D. Rodrigues. (2015) Evaluation of Rosuvastatin as an Organic Anion Transporting Polypeptide (OATP) Probe Substrate: In Vitro Transport and In Vivo Disposition in Cynomolgus Monkeys. Journal of Pharmacology and Experimental Therapeutics 353:2, pages 380-391.
Crossref
Hugues Beaufrère, Mark G. Papich, João Brandão, Javier Nevarez & Thomas N. TullyJr.Jr.. (2015) Plasma Drug Concentrations of Orally Administered Rosuvastatin in Hispaniolan Amazon Parrots ( Amazona ventralis ) . Journal of Avian Medicine and Surgery 29:1, pages 18-24.
Crossref
T Eley, Y‐H Han, S‐P Huang, B He, W Li, W Bedford, M Stonier, D Gardiner, K Sims, AD Rodrigues & RJ Bertz. (2014) Organic Anion Transporting Polypeptide‐Mediated Transport of, and Inhibition by, Asunaprevir, an Inhibitor of Hepatitis C Virus NS3 Protease. Clinical Pharmacology & Therapeutics 97:2, pages 159-166.
Crossref
Jingjing Sheng, Xiaoting Tian, Guanglin Xu, Zhitao Wu, Chen Chen, Le Wang, Lili Pan, Chenggang Huang & Guoyu Pan. (2015) The Hepatobiliary Disposition of Timosaponin B2 Is Highly Dependent on Influx/Efflux Transporters but Not Metabolism. Drug Metabolism and Disposition 43:1, pages 63-72.
Crossref
Sieto Bosgra, Evita van de Steeg, Maria L. Vlaming, Kitty C. Verhoeckx, Maarten T. Huisman, Miriam Verwei & Heleen M. Wortelboer. (2014) Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling. European Journal of Pharmaceutical Sciences 65, pages 156-166.
Crossref
Jiake He, Yang Yu, Bhagwat Prasad, Jeanne Link, Robert S. Miyaoka, Xijing Chen & Jashvant D. Unadkat. (2014) PET Imaging of Oatp-Mediated Hepatobiliary Transport of [ 11 C] Rosuvastatin in the Rat . Molecular Pharmaceutics 11:8, pages 2745-2754.
Crossref
Jan Šilhavý, Václav Zídek, Vladimír Landa, Miroslava Šimáková, Petr Mlejnek, Vojtěch Škop, Olena Oliyarnyk, Ludmila Kazdová, Massimiliano Mancini, Kathrin Saar, Herbert Schulz, Norbert Hübner, Theodore W. Kurtz & Michal Pravenec. (2014) Rosuvastatin Can Block Pro‐Inflammatory Actions of Transgenic Human C ‐Reactive Protein Without Reducing its Circulating Levels . Cardiovascular Therapeutics 32:2, pages 59-65.
Crossref
Nathan D. Pfeifer, Arlene S. Bridges, Brian C. Ferslew, Rhiannon N. Hardwick & Kim L. R. Brouwer. (2013) Hepatic Basolateral Efflux Contributes Significantly to Rosuvastatin Disposition II: Characterization of Hepatic Elimination by Basolateral, Biliary, and Metabolic Clearance Pathways in Rat Isolated Perfused Liver. Journal of Pharmacology and Experimental Therapeutics 347:3, pages 737-745.
Crossref
Nathan D. Pfeifer, Kyunghee Yang & Kim L. R. Brouwer. (2013) Hepatic Basolateral Efflux Contributes Significantly to Rosuvastatin Disposition I: Characterization of Basolateral Versus Biliary Clearance Using a Novel Protocol in Sandwich-Cultured Hepatocytes. Journal of Pharmacology and Experimental Therapeutics 347:3, pages 727-736.
Crossref
Nathan D. Pfeifer, Kevin B. Harris, Grace Zhixia Yan & Kim L. R. Brouwer. (2013) Determination of Intracellular Unbound Concentrations and Subcellular Localization of Drugs in Rat Sandwich-Cultured Hepatocytes Compared with Liver Tissue. Drug Metabolism and Disposition 41:11, pages 1949-1956.
Crossref
Kan Zhong. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 4 .
Tomoki Imaoka, Tsuyoshi Mikkaichi, Koji Abe, Masakazu Hirouchi, Noriko Okudaira & Takashi Izumi. (2013) Integrated Approach of In Vivo and In Vitro Evaluation of the Involvement of Hepatic Uptake Organic Anion Transporters in the Drug Disposition in Rats Using Rifampicin as an Inhibitor. Drug Metabolism and Disposition 41:7, pages 1442-1449.
Crossref
Dilek Iusuf, Anita van Esch, Michael Hobbs, Maxine Taylor, Kathryn E. Kenworthy, Evita van de Steeg, Els Wagenaar & Alfred H. Schinkel. (2013) Murine Oatp1a/1b Uptake Transporters Control Rosuvastatin Systemic Exposure Without Affecting Its Apparent Liver Exposure. Molecular Pharmacology 83:5, pages 919-929.
Crossref
Hannah M. Jones, Hugh A. Barton, Yurong Lai, Yi-an Bi, Emi Kimoto, Sarah Kempshall, Sonya C. Tate, Ayman El-Kattan, J. Brian Houston, Aleksandra Galetin & Katherine S. Fenner. (2012) Mechanistic Pharmacokinetic Modeling for the Prediction of Transporter-Mediated Disposition in Humans from Sandwich Culture Human Hepatocyte Data. Drug Metabolism and Disposition 40:5, pages 1007-1017.
Crossref
Ebba Bergman, Elin M. Matsson, Mikael Hedeland, Ulf Bondesson, Lars Knutson & Hans Lennernäs. (2013) Effect of a Single Gemfibrozil Dose on the Pharmacokinetics of Rosuvastatin in Bile and Plasma in Healthy Volunteers. The Journal of Clinical Pharmacology 50:9, pages 1039-1049.
Crossref
Jan H. Beumer, Julie L. Eiseman & Merrill J. Egorin. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 30 .
Katalin Jemnitz, Zsuzsa Veres, Regina Tugyi & Laszlo Vereczkey. (2010) Biliary efflux transporters involved in the clearance of rosuvastatin in sandwich culture of primary rat hepatocytes. Toxicology in Vitro 24:2, pages 605-610.
Crossref
Shizuya Yamashita, Kazumi Tsubakio-Yamamoto, Tohru Ohama, Yumiko Nakagawa-Toyama & Makoto Nishida. (2010) Molecular Mechanisms of HDL-Cholesterol Elevation by Statins and Its Effects on HDL Functions. Journal of Atherosclerosis and Thrombosis 17:5, pages 436-451.
Crossref
Loren M. Berry, Jonathan Roberts, Xuhai Be, Zhiyang Zhao & Min-Hwa Jasmine Lin. (2010) Prediction of V ss from In Vitro Tissue-Binding Studies . Drug Metabolism and Disposition 38:1, pages 115-121.
Crossref
Sean X. Peng, Beth A. Rockafellow, Tina M. Skedzielewski, Norman D. Huebert & William Hageman. (2009) Improved Pharmacokinetic and Bioavailability Support of Drug Discovery Using Serial Blood Sampling in Mice. Journal of Pharmaceutical Sciences 98:5, pages 1877-1884.
Crossref
Satoshi Kitamura, Kazuya Maeda, Yi Wang & Yuichi Sugiyama. (2008) Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin. Drug Metabolism and Disposition 36:10, pages 2014-2023.
Crossref
Hajime Fukuda, Rikiya Ohashi, Minoru Tsuda-Tsukimoto & Ikumi Tamai. (2008) Effect of Plasma Protein Binding on in Vitro-in Vivo Correlation of Biliary Excretion of Drugs Evaluated by Sandwich-Cultured Rat Hepatocytes. Drug Metabolism and Disposition 36:7, pages 1275-1282.
Crossref
Lucie MuchovaRonald J. WongMark HsuIchiro MoriokaLibor VitekJaroslav ZelenkaHenning SchröderDavid K. Stevenson. (2007) Statin treatment increases formation of carbon monoxide and bilirubin in mice: a novel mechanism of in vivo antioxidant protection. Canadian Journal of Physiology and Pharmacology 85:8, pages 800-810.
Crossref
Mitsuo Saito, Mutsuko Hirata, Tsutomu Urano, Shinji Miyake & Ryuichi Hasegawa. (2007) Comparative Analysis of Clinical and Non-Clinical Pharmacokinetic Interactions of Statins with Other Drugs. Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 33:4, pages 291-300.
Crossref
Kazumi Ohfuji, Seiichi Yano, Motonori Yamaguchi, Graham Smith, Masako Hirata, Hitoshi Shimada, Koji Izuishi, Jotaro Shinagawa & Kazuki Matsunaga. (2005) . Folia Pharmacologica Japonica 126:3, pages 213-219.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.