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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 10
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Research Article

Modelling the loss of metabolic capacities of cultured hepatocytes: application to measurement of Michaelis-Menten kinetic parameters in in vitro systems

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Pages 895-906 | Published online: 22 Sep 2008

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Sayed M. Derayea, Hirofumi Tsujino, Yukiko Oyama, Yoshinobu Ishikawa, Taku Yamashita & Tadayuki Uno. (2020) Impact of single nucleotide polymorphisms (R132Q and W120R) on the binding affinity and metabolic activity of CYP2C19 toward some therapeutically important substrates. Xenobiotica 50:12, pages 1510-1519.
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Joel A. Krauser, Yi Jin, Markus Walles, Ulrike Pfaar, James Sutton, Marion Wiesmann, Daniel Graf, Veronique Pflimlin-Fritschy, Thierry Wolf, Gian Camenisch & Piet Swart. (2015) Phenotypic and metabolic investigation of a CSF-1R kinase receptor inhibitor (BLZ945) and its pharmacologically active metabolite. Xenobiotica 45:2, pages 107-123.
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Erik Sjögren, Hans Lennernäs, Tommy B. Andersson, Johan Gråsjö & Ulf Bredberg. (2009) The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CL int ), Maximum Velocity of the Metabolic Reaction ( V max ), and Michaelis Constant ( K m ): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations . Drug Metabolism and Disposition 37:1, pages 47-58.
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Jørgen Hasselstrøm & Kristian Linnet. (2006) IN VITRO STUDIES ON QUETIAPINE METABOLISM USING THE SUBSTRATE DEPLETION APPROACH WITH FOCUS ON DRUG-DRUG INTERACTIONS. Drug Metabolism and Drug Interactions 21:3-4.
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Nadège Blanchard, Lysiane Richert, Brigitte Notter, Frederic Delobel, Pascale David, Philippe Coassolo & Thierry Lavé. (2004) Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes. European Journal of Pharmaceutical Sciences 23:2, pages 189-199.
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