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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 5
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Research Article

Identification of coenzyme A-related tolmetin metabolites in rats: relationship with reactive drug metabolites

J. Olsen Department of Analytical and Pharmaceutical Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark
,
I. Bjørnsdottir Novo Nordisk A/S, Drug Metabolism, 2670 Måløv, Denmark
&
S. Honorè Hansen Department of Analytical and Pharmaceutical Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark
Pages 561-570 | Published online: 22 Sep 2008

Citations (14)

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Read on this site (3)

Louis Leung, Amit S. Kalgutkar & R. Scott Obach. (2012) Metabolic activation in drug-induced liver injury. Drug Metabolism Reviews 44:1, pages 18-33.
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Marina C. Jeppsson, Christian H. Lindh, Monica H. Kristiansson, Jörn Nielsen & Bo A. G. Jönsson. (2009) Methylhexahydrophthalic anhydride adducted albumin tryptic peptides in nasal lavage fluid. Inhalation Toxicology 21:12, pages 1013-1020.
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Christian Skonberg, Jrgen Olsen, Kim Grimstrup Madsen, Steen Honor Hansen & Mark P Grillo. (2008) Metabolic activation of carboxylic acids. Expert Opinion on Drug Metabolism & Toxicology 4:4, pages 425-438.
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Articles from other publishers (11)

Christian Skonberg & Jørgen Olsen. (2023) A review of the synthesis, bioanalysis, and chemical reactivity of xenobiotic acyl-coenzyme a thioesters. Medicinal Chemistry Research 32:9, pages 2001-2015.
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Arun Tailor, James C. Waddington, Xiaoli Meng & B. Kevin Park. (2016) Mass Spectrometric and Functional Aspects of Drug–Protein Conjugation. Chemical Research in Toxicology 29:12, pages 1912-1935.
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Malin Darnell, Katarina Breitholtz, Emre M. Isin, Ulrik Jurva & Lars Weidolf. (2015) Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S-Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes. Chemical Research in Toxicology 28:5, pages 886-896.
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Howard Horng & Leslie Z. Benet. (2013) The Nonenzymatic Reactivity of the Acyl-Linked Metabolites of Mefenamic Acid toward Amino and Thiol Functional Group Bionucleophiles. Drug Metabolism and Disposition 41:11, pages 1923-1933.
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Malin Darnell & Lars Weidolf. (2013) Metabolism of Xenobiotic Carboxylic Acids: Focus on Coenzyme A Conjugation, Reactivity, and Interference with Lipid Metabolism. Chemical Research in Toxicology 26:8, pages 1139-1155.
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Antonia F. Stepan, Daniel P. Walker, Jonathan Bauman, David A. Price, Thomas A. Baillie, Amit S. Kalgutkar & Michael D. Aleo. (2011) Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States. Chemical Research in Toxicology 24:9, pages 1345-1410.
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Sophie L. Regan, James L. Maggs, Thomas G. Hammond, Craig Lambert, Dominic P. Williams & B. Kevin Park. (2010) Acyl glucuronides: the good, the bad and the ugly. Biopharmaceutics & Drug Disposition 31:7, pages 367-395.
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Chunze Li, Mark P. Grillo, Ilaria Badagnani, Kimberly L. Fife & Leslie Z. Benet. (2008) Differential Effects of Fibrates on the Metabolic Activation of 2-Phenylpropionic Acid in Rats. Drug Metabolism and Disposition 36:4, pages 682-687.
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Jørgen Olsen, Chunze Li, Christian Skonberg, Inga Bjørnsdottir, Ulrik Sidenius, Leslie Z. Benet & Steen Honoré Hansen. (2007) Studies on the Metabolism of Tolmetin to the Chemically Reactive Acyl-Coenzyme A Thioester Intermediate in Rats. Drug Metabolism and Disposition 35:5, pages 758-764.
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Shuguang Ma & Raju Subramanian. (2006) Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry. Journal of Mass Spectrometry 41:9, pages 1121-1139.
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Steen K. Johansen, Lone Sørensen & Lars Martiny. (2005) Fast and efficient tritium labelling of the nonsteroidal anti‐inflammatory drugs naproxen, tolmetin, and zomepirac. Journal of Labelled Compounds and Radiopharmaceuticals 48:8, pages 569-576.
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