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Risto O. Juvonen, Mira Kuusisto, Carolin Fohrgrup, Mari H. Pitkänen, Tapio J. Nevalainen, Seppo Auriola, Hannu Raunio, Markku Pasanen & Olli T. Pentikäinen. (2016) Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes. Xenobiotica 46:1, pages 14-24.
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Tuomas Rahikainen, Merja R. Häkkinen, Moshe Finel, Markku Pasanen & Risto O. Juvonen. (2013) A high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes. Xenobiotica 43:10, pages 853-861.
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H. Raunio, N. Pokela, K. Puhakainen, M. Rahnasto, T. Mauriala, S. Auriola & R. O. Juvonen. (2008) Nicotine metabolism and urinary elimination in mouse: in vitro and in vivo. Xenobiotica 38:1, pages 34-47.
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Guanglin Liu, Ruiyan Wang, Huan Chen, Ping Wu, Yaning Fu, Kaixin Li, Mingda Liu, Zhihao Shi, Yuan Zhang, Yue Su, Lingxiao Song, Hongwei Hou & Qingyuan Hu. (2022) Non-nicotine constituents in cigarette smoke extract enhance nicotine addiction through monoamine oxidase A inhibition. Frontiers in Neuroscience 16.
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Brett R. Winters, Tavleen K. Kochar, Phillip W. Clapp, Ilona Jaspers & Michael C. Madden. (2020) Impact of E-Cigarette Liquid Flavoring Agents on Activity of Microsomal Recombinant CYP2A6, the Primary Nicotine-Metabolizing Enzyme. Chemical Research in Toxicology 33:7, pages 1689-1697.
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John S. MarkowitzKennerly S. Patrick. (2017) The Clinical Pharmacokinetics of Amphetamines Utilized in the Treatment of Attention-Deficit/Hyperactivity Disorder. Journal of Child and Adolescent Psychopharmacology 27:8, pages 678-689.
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Xiao Deng, Qianghong Pu, Erhao Wang & Chao Yu. (2016) Celery extract inhibits mouse CYP2A5 and human CYP2A6 activities via different mechanisms. Oncology Letters 12:6, pages 5309-5314.
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Suzanne van de Nobelen, Anne S. Kienhuis & Reinskje Talhout. (2016) An Inventory of Methods for the Assessment of Additive Increased Addictiveness of Tobacco Products: Table 1.. Nicotine & Tobacco Research 18:7, pages 1546-1555.
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James C. Ermer, Michael Pennick & Glen Frick. (2016) Lisdexamfetamine Dimesylate: Prodrug Delivery, Amphetamine Exposure and Duration of Efficacy. Clinical Drug Investigation 36:5, pages 341-356.
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Mia Halme, Maija Pesonen, Ullastiina Hakala, Markku Pasanen, Kirsi Vähäkangas & Paula Vanninen. (2015)
Applying human and pig hepatic
in vitro
experiments for sulfur mustard study: Screening and identification of metabolites by liquid chromatography/tandem mass spectrometry
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Niina Tani, Risto O. Juvonen, Hannu Raunio, Muluneh Fashe, Jukka Leppänen, Bin Zhao, Rachel F. Tyndale & Minna Rahnasto-Rilla. (2014) Rational design of novel CYP2A6 inhibitors. Bioorganic & Medicinal Chemistry 22:23, pages 6655-6664.
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Pekka K. Poutiainen, Tuulia Huhtala, Tiina Jääskeläinen, Aleksanteri Petsalo, Jenni Küblbeck, Sanna Kaikkonen, Jorma J. Palvimo, Hannu Raunio, Ale Närvänen, Mikael Peräkylä, Risto O. Juvonen, Paavo Honkakoski, Reino Laatikainen & Juha T. Pulkkinen. (2014) Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator. Molecular and Cellular Endocrinology 387:1-2, pages 8-18.
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Linda C. Blake, Anuradha Roy, David Neul, Frank J. Schoenen, Jeffrey Aubé & Emily E. Scott. (2013) Benzylmorpholine Analogs as Selective Inhibitors of Lung Cytochrome P450 2A13 for the Chemoprevention of Lung Cancer in Tobacco Users. Pharmaceutical Research 30:9, pages 2290-2302.
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Laura E. Martikainen, Minna Rahnasto-Rilla, Silvie Neshybova, Maija Lahtela-Kakkonen, Hannu Raunio & Risto O. Juvonen. (2012) Interactions of inhibitor molecules with the human CYP2E1 enzyme active site. European Journal of Pharmaceutical Sciences 47:5, pages 996-1005.
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Minna K. Rahnasto, Hannu A. Raunio, Carsten Wittekindt, Kaisa A. Salminen, Jukka Leppänen, Risto O. Juvonen, Antti Poso & Maija K. Lahtela-Kakkonen. (2011) Identification of novel CYP2A6 inhibitors by virtual screening. Bioorganic & Medicinal Chemistry 19:23, pages 7186-7193.
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Javed Iqbal, Duangkamon Sakloetsakun & Andreas Bernkop-Schnürch. (2011) Thiomers: Inhibition of cytochrome P450 activity. European Journal of Pharmaceutics and Biopharmaceutics 78:3, pages 361-365.
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Max K. Leong, Yen-Ming Chen, Hong-Bin Chen & Po-Hong Chen. (2008) Development of a New Predictive Model for Interactions with Human Cytochrome P450 2A6 Using Pharmacophore Ensemble/Support Vector Machine (PhE/SVM) Approach. Pharmaceutical Research 26:4, pages 987-1000.
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M Rahnasto, C Wittekindt, R O Juvonen, M Turpeinen, A Petsalo, O Pelkonen, A Poso, G Stahl, H-D Höltje & H Raunio. (2007) Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme—an in silico approach. The Pharmacogenomics Journal 8:5, pages 328-338.
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Eric C.K. Siu & Rachel F. Tyndale. (2008) Selegiline Is a Mechanism-Based Inactivator of CYP2A6 Inhibiting Nicotine Metabolism in Humans and Mice. Journal of Pharmacology and Experimental Therapeutics 324:3, pages 992-999.
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Ana C.A.X. De-Oliveira, Anndressa C. Da-Matta & Francisco J.R. Paumgartten. (2006) Plasmodium berghei (ANKA): Infection induces CYP2A5 and 2E1 while depressing other CYP isoforms in the mouse liver. Experimental Parasitology 113:4, pages 256-261.
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Kimiko Aoki, Yasuharu Kashiwagura, Toru Horie, Hitoshi Sato, Chise Tateno, Naoki Ozawa & Katsutoshi Yoshizato. (2006) Characterization of Humanized Liver from Chimeric Mice Using Coumarin as a Human CYP2A6 and Mouse CYP2A5 Probe. Drug Metabolism and Pharmacokinetics 21:4, pages 277-285.
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Janne Hukkanen, Pleyton JacobIIIIII & Neal L. Benowitz. (2005) Metabolism and Disposition Kinetics of Nicotine. Pharmacological Reviews 57:1, pages 79-115.
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Minna Rahnasto, Hannu Raunio, Antti Poso, Carsten Wittekindt & Risto O. Juvonen. (2004) Quantitative Structure−Activity Relationship Analysis of Inhibitors of the Nicotine Metabolizing CYP2A6 Enzyme. Journal of Medicinal Chemistry 48:2, pages 440-449.
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