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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 6
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Research Article

In vitro inhibition of human small intestinal and liver microsomal astemizole O -demethylation: different contribution of CYP2J2 in the small intestine and liver

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Pages 615-623 | Published online: 22 Sep 2008

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Alexandra M. Wiley, Jade Yang, Rivcka Madhani, Abhinav Nath & Rheem A. Totah. (2024) Investigating the association between CYP2J2 inhibitors and QT prolongation: a literature review. Drug Metabolism Reviews 0:0, pages 1-19.
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Michael Murray. (2016) CYP2J2 – regulation, function and polymorphism. Drug Metabolism Reviews 48:3, pages 351-368.
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Meijuan Xu, Wenzheng Ju, Haiping Hao, Guangji Wang & Ping Li. (2013) Cytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance. Drug Metabolism Reviews 45:3, pages 311-352.
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Wei Zhang, Mary W Roederer, Wang-Qing Chen, Lan Fan & Hong-Hao Zhou. (2012) Pharmacogenetics of Drugs Withdrawn from the Market. Pharmacogenomics 13:2, pages 223-231.
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A. Messina, S. Nencioni, P. G. Gervasi, K. H. Gotlinger, M. L. Schwartzman & V. Longo. (2010) Molecular cloning and enzymatic characterization of sheep CYP2J. Xenobiotica 40:2, pages 109-118.
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Hongjian Zhang, Carl D Davis, Michael W Sinz & A David Rodrigues. (2007) Cytochrome P450 reaction-phenotyping: an industrial perspective. Expert Opinion on Drug Metabolism & Toxicology 3:5, pages 667-687.
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H. Yamazaki, A. Okayama, N. Imai, F. P. Guengerich & M. Shimizu. (2006) Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations. Xenobiotica 36:12, pages 1201-1209.
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Jacqueline Wen Hui Leow & Eric Chun Yong Chan. (2024) CYP2J2-mediated metabolism of arachidonic acid in heart: A review of its kinetics, inhibition and role in heart rhythm control. Pharmacology & Therapeutics 258, pages 108637.
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Hani Zaher & George Zhang. 2023. Oral Bioavailability and Drug Delivery. Oral Bioavailability and Drug Delivery 737 756 .
Albert P. Li. 2021. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity 79 137 .
Helinä Kahma, Laura Aurinsalo, Mikko Neuvonen, Jani Katajamäki, Marie-Noëlle Paludetto, Jenni Viinamäki, Terhi Launiainen, Anne M. Filppula, Aleksi Tornio, Mikko Niemi & Janne T. Backman. (2021) An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity. European Journal of Pharmaceutical Sciences 162, pages 105810.
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Jian Lu, Ang Chen, Xinrun Ma, Xuyang Shang, Yuanjin Zhang, Yuanqing Guo, Mingyao Liu & Xin Wang. (2020) Generation and Characterization of Cytochrome P450 2J3/10 CRISPR/Cas9 Knockout Rat Model. Drug Metabolism and Disposition 48:11, pages 1129-1136.
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Marco Sisignano, Dieter Steinhilber, Michael J. Parnham & Gerd Geisslinger. (2020) Exploring CYP2J2: lipid mediators, inhibitors and therapeutic implications. Drug Discovery Today 25:9, pages 1744-1753.
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Hyun‐Ji Kim, Hyunyoung Lee, Hyeon‐Kyeong Ji, Taeho Lee & Kwang‐Hyeon Liu. (2019) Screening of ten cytochrome P450 enzyme activities with 12 probe substrates in human liver microsomes using cocktail incubation and liquid chromatography–tandem mass spectrometry. Biopharmaceutics & Drug Disposition 40:3-4, pages 101-111.
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Pierre Lafite, François André, Joan Graves, Darryl Zeldin, Patrick Dansette & Daniel Mansuy. (2018) Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2. International Journal of Molecular Sciences 19:7, pages 2066.
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Jian Lu, Daozhi Liu, Xiaojing Zhou, Ang Chen, Zhenran Jiang, Xiyun Ye, Mingyao Liu & Xin Wang. (2018) Plant natural product plumbagin presents potent inhibitory effect on human cytochrome P450 2J2 enzyme. Phytomedicine 39, pages 137-145.
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Dany Spaggiari, Youssef Daali & Serge Rudaz. (2016) An extensive cocktail approach for rapid risk assessment of in vitro CYP450 direct reversible inhibition by xenobiotic exposure. Toxicology and Applied Pharmacology 302, pages 41-51.
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F. Peter Guengerich. 2015. Cytochrome P450. Cytochrome P450 523 785 .
José A. G. Agúndez, Félix J. Jiménez-Jiménez, Hortensia Alonso-Navarro & Elena García-Martín. (2014) Drug and xenobiotic biotransformation in the blood–brain barrier: a neglected issue. Frontiers in Cellular Neuroscience 8.
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Boram Lee, Zhexue Wu, Sang Hyun Sung, Taeho Lee, Kyung-Sik Song, Min Young Lee & Kwang-Hyeon Liu. (2014) Potential of decursin to inhibit the human cytochrome P450 2J2 isoform. Food and Chemical Toxicology 70, pages 94-99.
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Boram Lee, Wonku Kang, Jongcheol Shon, Ki Hun Park, Kyung-Sik Song & Kwang-Hyeon Liu. (2014) Potential of 4′-(p-toluenesulfonylamide)-4-hydroxychalcone to inhibit the human cytochrome P450 2J2 isoform. Journal of the Korean Society for Applied Biological Chemistry 57:1, pages 31-34.
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Zhexue Wu, Boram Lee, Kyung-Sik Song & Kwang-Hyeon Liu. (2013) Inhibitory Potential of Thelephoric Acid on CYP2J2 Activities in Human Liver Microsomes. Journal of Life Science 23:9, pages 1126-1132.
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Caroline A. Lee, J. P. JonesIIIIII, Jonathan Katayama, Rüdiger Kaspera, Ying Jiang, Sascha Freiwald, Evan Smith, Gregory S. Walker & Rheem A. Totah. (2012) Identifying a Selective Substrate and Inhibitor Pair for the Evaluation of CYP2J2 Activity. Drug Metabolism and Disposition 40:5, pages 943-951.
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Kwang-Hyeon Liu. (2011) Screening of Potential Anticancer Compounds from Marketed Drugs: Aripiprazole, Haloperidol, Miconazole, and Terfenadine Inhibit Cytochrome P450 2J2. Journal of Life Science 21:11, pages 1558-1564.
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Anima Ghosal, Xiaowen Lu, Natalia Penner, Lan Gao, Ragu Ramanathan, Swapan K. Chowdhury, Narendra S. Kishnani & Kevin B. Alton. (2011) Identification of Human Liver Cytochrome P450 Enzymes Involved in the Metabolism of SCH 530348 (Vorapaxar), a Potent Oral Thrombin Protease-Activated Receptor 1 Antagonist. Drug Metabolism and Disposition 39:1, pages 30-38.
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Caroline A. Lee, David Neul, Andrea Clouser-Roche, Deepak Dalvie, Michael R. Wester, Ying Jiang, J. P. JonesIIIIII, Sascha Freiwald, Michael Zientek & Rheem A. Totah. (2010) Identification of Novel Substrates for Human Cytochrome P450 2J2. Drug Metabolism and Disposition 38:2, pages 347-356.
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Kirstin Thelen & Jennifer B Dressman. (2009) Cytochrome P450-mediated metabolism in the human gut wall. Journal of Pharmacy and Pharmacology 61:5, pages 541-558.
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Weihua Li, Yun Tang, Hong Liu, Jiagao Cheng, Weiliang Zhu & Hualiang Jiang. (2007) Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking. Proteins: Structure, Function, and Bioinformatics 71:2, pages 938-949.
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Kwang-Hyeon Liu, Mi-Gyung Kim, Dong-Jun Lee, Yune-Jung Yoon, Min-Jung Kim, Ji-Hong Shon, Chang Soo Choi, Young Kil Choi, Zeuresenay Desta & Jae-Gook Shin. (2006) Characterization of Ebastine, Hydroxyebastine, and Carebastine Metabolism by Human Liver Microsomes and Expressed Cytochrome P450 Enzymes: Major Roles for CYP2J2 and CYP3A. Drug Metabolism and Disposition 34:11, pages 1793-1797.
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Pierre Lafite, Sylvie Dijols, Didier Buisson, Anne-Christine Macherey, Darryl C. Zeldin, Patrick M. Dansette & Daniel Mansuy. (2006) Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2. Bioorganic & Medicinal Chemistry Letters 16:10, pages 2777-2780.
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Sang Seop Lee, Hye-Eun Jeong, Kwang-Hyeon Liu, Ji-Young Ryu, Taesung Moon, Chang No Yoon, S. June Oh, Chul-Ho Yun & Jae-Gook Shin. (2005) Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity. Pharmacogenetics and Genomics 15:2, pages 105-113.
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