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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 7
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Research Article

Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells

K. Swales School of Biomedical and Life Sciences, University of Surrey, Guildford, UK
,
N. Plant GlaxoSmithKline, Drug Metabolism and Pharmacokinetics, Ware, UK
,
A. Ayrton School of Biomedical and Life Sciences, University of Surrey, Guildford, UK
,
S. Hood GlaxoSmithKline, Drug Metabolism and Pharmacokinetics, Ware, UK
&
G. Gibson School of Biomedical and Life Sciences, University of Surrey, Guildford, UK
Pages 703-716 | Published online: 02 Jul 2010

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G. Gordon Gibson, Anna Phillips, Sihem Aouabdi, Kate Plant & Nick Plant. (2006) Transcriptional Regulation of the Human Pregnane-X Receptor. Drug Metabolism Reviews 38:1-2, pages 31-49.
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Yaowen Liu, Jiaojun Wei, Jinfu Lu, Dongmei Lei, Shili Yan & Xiaohong Li. (2016) Micropatterned coculture of hepatocytes on electrospun fibers as a potential in vitro model for predictive drug metabolism. Materials Science and Engineering: C 63, pages 475-484.
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Douglas M. Frederick, Erina Y. Jacinto, Niti N. Patel, Thomas H. Rushmore, Ruy Tchao & Peter J. Harvison. (2011) Cytotoxicity of 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT) and analogues in wild type and CYP3A4 stably transfected HepG2 cells. Toxicology in Vitro 25:8, pages 2113-2119.
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Philip Martin, Robert Riley, Paul Thompson, Dominic Williams, David Back & Andrew Owen. (2010) Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells. Acta Pharmacologica Sinica 31:1, pages 51-65.
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S. Harmsen, A. S. Koster, J. H. Beijnen, J. H. M. Schellens & I. Meijerman. (2008) Comparison of Two Immortalized Human Cell Lines to Study Nuclear Receptor-Mediated CYP3A4 Induction. Drug Metabolism and Disposition 36:6, pages 1166-1171.
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P Martin, R Riley, D J Back & A Owen. (2008) Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells. British Journal of Pharmacology 153:4, pages 805-819.
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Yoyo T.Y. LiKaren E. SwalesGareth J. ThomasTimothy D. WarnerDavid Bishop-Bailey. (2007) Farnesoid X Receptor Ligands Inhibit Vascular Smooth Muscle Cell Inflammation and Migration. Arteriosclerosis, Thrombosis, and Vascular Biology 27:12, pages 2606-2611.
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Hai-Lin Fang, Stephen C. Strom, Ewa Ellis, Zhengbo Duanmu, Jiaqi Fu, Zofia Duniec-Dmuchowski, Charles N. Falany, Josie L. Falany, Thomas A. Kocarek & Melissa Runge-Morris. (2007) Positive and Negative Regulation of Human Hepatic Hydroxysteroid Sulfotransferase (SULT2A1) Gene Transcription by Rifampicin: Roles of Hepatocyte Nuclear Factor 4α and Pregnane X Receptor. Journal of Pharmacology and Experimental Therapeutics 323:2, pages 586-598.
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Jue Wang, Anders Sönnerborg, Anders Rane, Filip Josephson, Stefan Lundgren, Lars Ståhle & Magnus Ingelman-Sundberg. (2006) Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz. Pharmacogenetics and Genomics 16:3, pages 191-198.
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Sihem Aouabdi, Gordon Gibson & Nick Plant. (2006) TRANSCRIPTIONAL REGULATION OF THE PXR GENE: IDENTIFICATION AND CHARACTERIZATION OF A FUNCTIONAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α BINDING SITE WITHIN THE PROXIMAL PROMOTER OF PXR . Drug Metabolism and Disposition 34:1, pages 138-144.
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Elton Richard Kisanga, Line L. Haugan Moi, Jennifer Gjerde, Gunnar Mellgren & Ernst A. Lien. (2005) Induction of hepatic drug-metabolising enzymes and tamoxifen metabolite profile in relation to administration route during low-dose treatment in nude rats. The Journal of Steroid Biochemistry and Molecular Biology 94:5, pages 489-498.
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Anna Phillips, Steve R. Hood, G. Gordon Gibson & Nick J. Plant. (2005) IMPACT OF TRANSCRIPTION FACTOR PROFILE AND CHROMATIN CONFORMATION ON HUMAN HEPATOCYTE CYP3A GENE EXPRESSION. Drug Metabolism and Disposition 33:2, pages 233-242.
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D. K. Walker. (2004) The use of pharmacokinetic and pharmacodynamic data in the assessment of drug safety in early drug development. British Journal of Clinical Pharmacology 58:6, pages 601-608.
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Nick Plant. (2004) Interaction networks: coordinating responses to xenobiotic exposure. Toxicology 202:1-2, pages 21-32.
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