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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 7
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Research Article

Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: similarities and difference in the metabolism of pitavastatin in monkeys and humans

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Pages 789-803 | Published online: 02 Jul 2010

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Paul Chan, Li Shao, Brian Tomlinson, Yuzhen Zhang & Zhong-Min Liu. (2019) An evaluation of pitavastatin for the treatment of hypercholesterolemia. Expert Opinion on Pharmacotherapy 20:1, pages 103-113.
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Miao Hu & Brian Tomlinson. (2014) Evaluation of the pharmacokinetics and drug interactions of the two recently developed statins, rosuvastatin and pitavastatin. Expert Opinion on Drug Metabolism & Toxicology 10:1, pages 51-65.
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Leiv Ose. (2010) Pitavastatin: a distinctive lipid-lowering drug. Clinical Lipidology 5:3, pages 309-323.
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Y. Uno, T. Kumano, G. Kito, R. Nagata, T. Kamataki & H. Fujino. (2007) CYP2C76-mediated species difference in drug metabolism: A comparison of pitavastatin metabolism between monkeys and humans. Xenobiotica 37:1, pages 30-43.
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H. Fujino, T. Saito, Y. Tsunenari, J. Kojima & T. Sakaeda. (2004) Metabolic properties of the acid and lactone forms of HMG-CoA reductase inhibitors. Xenobiotica 34:11-12, pages 961-971.
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Articles from other publishers (19)

Takayoshi Nakaoka, Ken-ichi Kaneko, Satsuki Irie, Aya Mawatari, Ami Igesaka, Yuta Uetake, Hidenori Ochiai, Takashi Niwa, Emi Yamano, Yasuhiro Wada, Masaaki Tanaka, Kohei Kotani, Hideki Kawahata, Joji Kawabe, Yukio Miki, Hisashi Doi, Takamitsu Hosoya, Maeda Kazuya, Hiroyuki Kusuhara, Yuichi Sugiyama & Yasuyoshi Watanabe. (2022) Clinical evaluation of [18F]pitavastatin for quantitative analysis of hepatobiliary transporter activity. Drug Metabolism and Pharmacokinetics 44, pages 100449.
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Joo Young Na, Eunsol Yang, Jae‐Hoon Kim, In Sun Kwon, Eun‐Heui Jin, Kyung‐Sang Yu, Jinsook Kim, SeungHwan Lee & Jang Hee Hong. (2022) Comparative Pharmacokinetics Between a Fixed‐Dose Combination of Pitavastatin/Valsartan 4/160 mg and the Corresponding Individual Components Through a Partial Replicated Crossover Design in Healthy Male Subjects. Clinical Pharmacology in Drug Development 11:5, pages 615-622.
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Ziqiang Li, Shuang Tian, Zengguang Wu, Xueyan Xu, Lei Lei, Yanfen Li, Baohe Wang & Yuhong Huang. (2021) Pharmacokinetic herb-disease-drug interactions: Effect of ginkgo biloba extract on the pharmacokinetics of pitavastatin, a substrate of Oatp1b2, in rats with non-alcoholic fatty liver disease. Journal of Ethnopharmacology 280, pages 114469.
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Anne M. Filppula, Päivi Hirvensalo, Heli Parviainen, Vilma E. Ivaska, K. Ivar Lönnberg, Feng Deng, Jenni Viinamäki, Mika Kurkela, Mikko Neuvonen & Mikko Niemi. (2021) Comparative Hepatic and Intestinal Metabolism and Pharmacodynamics of Statins. Drug Metabolism and Disposition 49:8, pages 658-667.
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Zhu Luo, Yunhui Zhang, Jingkai Gu, Ping Feng & Ying Wang. (2015) Pharmacokinetic Properties of Single- and Multiple-Dose Pitavastatin Calcium Tablets in Healthy Chinese Volunteers. Current Therapeutic Research 77, pages 52-57.
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Lorenzo Arnaboldi & Alberto Corsini. (2015) Could changes in adiponectin drive the effect of statins on the risk of new-onset diabetes? The case of pitavastatin. Atherosclerosis Supplements 16, pages 1-27.
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Chunying Gao. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 6 .
Tsuyoshi Takahashi, Tatsuyuki Ohtsuka, Takahiro Yoshikawa, Ichiro Tatekawa, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki & Toshiyuki Kume. (2013) Pitavastatin as an In Vivo Probe for Studying Hepatic Organic Anion Transporting Polypeptide-Mediated Drug–Drug Interactions in Cynomolgus Monkeys. Drug Metabolism and Disposition 41:10, pages 1875-1882.
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Xiemin Qi, Li Ding, Aidong Wen, Na Zhou, Xiaolang Du & Shailendra Shakya. (2013) Simple LC–MS/MS methods for simultaneous determination of pitavastatin and its lactone metabolite in human plasma and urine involving a procedure for inhibiting the conversion of pitavastatin lactone to pitavastatin in plasma and its application to a pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis 72, pages 8-15.
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Yoshiyuki Shirasaka, Kensuke Suzuki, Megumi Shichiri, Takeo Nakanishi & Ikumi Tamai. (2011) Intestinal Absorption of HMG-CoA Reductase Inhibitor Pitavastatin Mediated by Organic Anion Transporting Polypeptide and P-Glycoprotein/Multidrug Resistance 1. Drug Metabolism and Pharmacokinetics 26:2, pages 171-179.
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Guo-ping Yang, Hong Yuan, Bin Tang, Wei Zhang, Lian-sheng Wang, Zhi-jun Huang, Dong-sheng Ou-Yang, Gui-xiang Zhang & Hong-hao Zhou. (2010) Lack of effect of genetic polymorphisms of SLCO1B1 on the lipid-lowering response to pitavastatin in Chinese patients. Acta Pharmacologica Sinica 31:3, pages 382-386.
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Hideki Fujino, Tsuyoshi Saito, Shin-ichiro Ogawa & Junji Kojima. (2005) Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. Journal of Pharmacy and Pharmacology 57:10, pages 1305-1311.
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Jian Wei Deng, Im-Sook Song, Ho Jung Shin, Chang-Woo Yeo, Doo-Yeoun Cho, Ji-Hong Shon & Jae-Gook Shin. (2008) The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. Pharmacogenetics and Genomics 18:5, pages 424-433.
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Xiaoyan Zhu, Jianguo Sun, Haiping Hao, Guangji Wang, Xiaoling Hu, Hua Lv, Shenghua Gu, Xiaoming Wu & Jinyi Xu. (2008) Simultaneous determination of multiple angiotensin type 1 receptor antagonists and its application to high-throughput pharmacokinetic study: Cassette dosing versus cassette analysis. International Journal of Mass Spectrometry 272:2-3, pages 127-136.
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Lei Tian, Yiling Huang, Youhong Jia, Lu Hua & Yishi Li. (2008) Development and validation of a liquid chromatography–tandem mass spectrometric assay for pitavastatin and its lactone in human plasma and urine. Journal of Chromatography B 865:1-2, pages 127-132.
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I Ieiri, S Suwannakul, K Maeda, H Uchimaru, K Hashimoto, M Kimura, H Fujino, M Hirano, H Kusuhara, S Irie, S Higuchi & Y Sugiyama. (2007) SLCO1B1 (OATP1B1, an Uptake Transporter) and ABCG2 (BCRP, an Efflux Transporter) Variant Alleles and Pharmacokinetics of Pitavastatin in Healthy Volunteers. Clinical Pharmacology & Therapeutics 82:5, pages 541-547.
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Toshiyuki Sakaeda, Hideki Fujino, Chiho Komoto, Mikio Kakumoto, Jiang-shu Jin, Koichi Iwaki, Kohshi Nishiguchi, Tsutomu Nakamura, Noboru Okamura & Katsuhiko Okumura. (2006) Effects of Acid and Lactone Forms of Eight HMG-CoA Reductase Inhibitors on CYP-Mediated Metabolism and MDR1-Mediated Transport. Pharmaceutical Research 23:3, pages 506-512.
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R.Y.A. Mukhtar, J. Reid & J.P.D. Reckless. (2005) Pitavastatin. International Journal of Clinical Practice 59:2, pages 239-252.
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H. Fujino, T. Saito, Y. Tsunenari & J. Kojima. (2004) Effect of Gemfibrozil on the Metabolism of Pitavastatin - Determining the Best Animal Model for Human CYP And UGT Activities. Drug Metabolism and Drug Interactions 20:1-2.
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