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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 11
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Research Article

Almokalant glucuronidation in human liver and kidney microsomes: evidence for the involvement of UGT1A9 and 2B7

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Pages 1073-1083 | Received 11 Apr 2003, Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Danyi Lu, Hui Liu, Wencai Ye, Ying Wang & Baojian Wu. (2017) Structure- and isoform-specific glucuronidation of six curcumin analogs. Xenobiotica 47:4, pages 304-313.
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Liangliang Zhu, Guangbo Ge, Yong Liu, Guiyuan He, Sicheng Liang, Zhongze Fang, Peipei Dong, Yunfeng Cao & Ling Yang. (2012) Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9. Xenobiotica 42:10, pages 1001-1008.
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Michal Šiller, Pavel Anzenbacher, Eva Anzenbacherová, Karel Doležal & Miroslav Strnad. (2011) In vitro interaction of a novel neutrophil growth factor with human liver microsomal cytochromes P450 and the contribution of UDP-glucuronosyltransferases to its metabolism. Xenobiotica 41:11, pages 934-944.
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Petra Jančová, Michal Šiller, Eva Anzenbacherová, Vladimír Křen, Pavel Anzenbacher & Vilím Šimánek. (2011) Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases. Xenobiotica 41:9, pages 743-751.
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Kathleen M. Knights & John O. Miners. (2010) Renal UDP-glucuronosyltransferases and the glucuronidation of xenobiotics and endogenous mediators. Drug Metabolism Reviews 42:1, pages 63-73.
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Articles from other publishers (13)

T.P. Sri Laasya, Shikha Thakur, Ramarao Poduri & Gaurav Joshi. (2020) Current insights toward kidney injury: Decrypting the dual role and mechanism involved of herbal drugs in inducing kidney injury and its treatment. Current Research in Biotechnology 2, pages 161-175.
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Kathleen M. Knights, Andrew Rowland & John O. Miners. (2013) Renal drug metabolism in humans: the potential for drug–endobiotic interactions involving cytochrome P450 ( CYP ) and UDP ‐glucuronosyltransferase ( UGT ) . British Journal of Clinical Pharmacology 76:4, pages 587-602.
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Andrew V. Stachulski & Xiaoli Meng. (2013) Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides. Natural Product Reports 30:6, pages 806.
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Alexander V. LyubimovShalu Jhajra, Ninad Ramesh Varkhede, Deepak Suresh Ahire, Bukke Vidyasagar Naik, Bhagwat Prasad, Jyoti Paliwal & Saranjit Singh. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 99 .
Alexander V. LyubimovRobert S. Foti & Michael B. Fisher. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 71 .
Jiping Wang, Allan M Evans, Kathleen M Knights & John O Miners. (2011) Differential disposition of intra-renal generated and preformed glucuronides: studies with 4-methylumbelliferone and 4-methylumbelliferyl glucuronide in the filtering and nonfiltering isolated perfused rat kidney. Journal of Pharmacy and Pharmacology 63:4, pages 507-514.
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James Smith & Viktor Stein. (2009) SPORCalc: A development of a database analysis that provides putative metabolic enzyme reactions for ligand-based drug design. Computational Biology and Chemistry 33:2, pages 149-159.
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Yuji Mano, Takashi Usui & Hidetaka Kamimura. (2005) In vitro inhibitory effects of non‐steroidal anti‐inflammatory drugs on 4‐methylumbelliferone glucuronidation in recombinant human UDP‐glucuronosyltransferase 1A9—potent inhibition by niflumic acid . Biopharmaceutics & Drug Disposition 27:1, pages 1-6.
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Adam G. Staines, Brian Burchell, Gábor Bánhegyi, József Mandl & Miklós Csala. (2005) Application of high-performance liquid chromatography–electrospray ionization–mass spectrometry to measure microsomal membrane transport of glucuronides. Analytical Biochemistry 342:1, pages 45-52.
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Adam G. STAINESPavel SINDELAR, Michael W. H. COUGHTRIEBrian BURCHELL. (2004) Farnesol is glucuronidated in human liver, kidney and intestine in vitro , and is a novel substrate for UGT2B7 and UGT1A1 . Biochemical Journal 384:3, pages 637-645.
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Adam G. Staines, Michael W. H. Coughtrie & Brian Burchell. (2004) N -Glucuronidation of Carbamazepine in Human Tissues Is Mediated by UGT2B7 . Journal of Pharmacology and Experimental Therapeutics 311:3, pages 1131-1137.
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Yuji Mano, Takashi Usui & Hidetaka Kamimura. (2004) Effects of β ‐estradiol and propofol on the 4‐methylumbelliferone glucuronidation in recombinant human UGT isozymes 1A1, 1A8 and 1A9 . Biopharmaceutics & Drug Disposition 25:8, pages 339-344.
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Hugo Girard, Michael H Court, Olivier Bernard, Louis-Charles Fortier, Lyne Villeneuve, Qin Hao, David J Greenblatt, Lisa L von Moltke, Louis Perussed & Chantal Guillemette. (2004) Identification of common polymorphisms in the promoter of the UGT1A9 gene. Pharmacogenetics 14:8, pages 501-515.
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