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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 1
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Original Article

Comparison of the metabolism of ethylene glycol and glycolic acid in vitro by precision-cut tissue slices from female rat, rabbit and human liver

E. D. Booth Molecular Toxicology Department, Shell International Chemicals BV, Shell Research and Technology Centre Amsterdam, PO Box 38000,1030 BN Amsterdam, the Netherlands
,
O. Dofferhoff Molecular Toxicology Department, Shell International Chemicals BV, Shell Research and Technology Centre Amsterdam, PO Box 38000,1030 BN Amsterdam, the Netherlands
,
P. J. Boogaard Present address: Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield SK10 4TJ, UK
&
W. P. Watson Present address: Shell International BV, Shell Health Services, PO Box 162, 2501 AN, The Hague, the NetherlandsCorrespondence[email protected]
Pages 31-48 | Received 07 Jul 2003, Published online: 12 Jul 2010

Citations (20)

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Gregory M. Fahy, Na Guan, Inge A. M. de Graaf, Yuansheng Tan, Lenetta Griffin & Geny M. M. Groothuis. (2013) Cryopreservation of precision-cut tissue slices. Xenobiotica 43:1, pages 113-132.
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Richard A. Corley, M. E. Meek & Edward W. Carney. (2005) Mode of Action: Oxalate Crystal-Induced Renal Tubule Degeneration and Glycolic Acid-Induced Dysmorphogenesis—Renal and Developmental Effects of Ethylene Glycol. Critical Reviews in Toxicology 35:8-9, pages 691-702.
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Articles from other publishers (18)

Szabina A. Stice & Edward W. Carney. 2022. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 803 814 .
Grażyna E. Sroga & Deepak Vashishth. (2021) Controlled Formation of Carboxymethyllysine in Bone Matrix through Designed Glycation Reaction. JBMR Plus 5:11.
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Faik GÖKALP. (2021) The effective ethanol rate against the toxicity of ethylene glycol. Turkish Computational and Theoretical Chemistry 5:1, pages 20-26.
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Gregory M. Fahy & Brian Wowk. 2021. Cryopreservation and Freeze-Drying Protocols. Cryopreservation and Freeze-Drying Protocols 27 97 .
Yunxia Yang, Wenda Wu & Aibo Wu. 2019. Food Safety & Mycotoxins. Food Safety & Mycotoxins 33 64 .
Jeff Fowles, Marcy Banton, Joanna Klapacz & Hua Shen. (2017) A toxicological review of the ethylene glycol series: Commonalities and differences in toxicity and modes of action. Toxicology Letters 278, pages 66-83.
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Edward W. Carney & Szabina A. Stice. 2017. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 797 809 .
Ronald D. HoodPatrick J. Wier. 2011. Developmental and Reproductive Toxicology: A Practical Approach. Developmental and Reproductive Toxicology: A Practical Approach 518 541 .
Ming Xing Huang, Xiao Mou Peng, Lin Gu & Gui Hua Chen. (2011) Pre-existing liver cirrhosis reduced the toxic effect of diethylene glycol in a rat model due to the impaired hepatic alcohol dehydrogenase. Toxicology and Industrial Health 27:8, pages 742-753.
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R.A. Corley, S.A. Saghir, M.J. Bartels, S.C. Hansen, J. Creim, K.E. McMartin & W.M. Snellings. (2011) Extension of a PBPK model for ethylene glycol and glycolic acid to include the competitive formation and clearance of metabolites associated with kidney toxicity in rats and humans. Toxicology and Applied Pharmacology 250:3, pages 229-244.
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Edward W. Carney, Belen Tornesi, Ashley B. Liberacki, Daniel A. Markham, Karl K. Weitz, Teressa M. Luders, Kristine G. Studniski, John C. Blessing, Richard A. Gies & Richard A. Corley. (2011) The Impact of Dose Rate on Ethylene Glycol Developmental Toxicity and Pharmacokinetics in Pregnant CD Rats. Toxicological Sciences 119:1, pages 178-188.
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Edward W. Carney. 2011. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 607 615 .
Edward W. Carney, Belen Tornesi, Daniel A. Markham, Reza J. Rasoulpour & Nigel Moore. (2008) Species‐specificity of ethylene glycol‐induced developmental toxicity: toxicokinetic and whole embryo culture studies in the rabbit. Birth Defects Research Part B: Developmental and Reproductive Toxicology 83:6, pages 573-581.
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Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:3, pages 257-405.
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Fazlul Huq & Deena Ababneh. (2006) Molecular Modelling Analysis of the Metabolic Activation of Ethylene Glycol. Journal of Pharmacology and Toxicology 2:1, pages 54-62.
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Martin Wolff, Nico Schaefer, Christian Rabe, Ulrich Spengler & Andreas Hirner. (2005) Successful transplantation of a liver from a donor with fatal ethylene glycol poisoning. Liver Transplantation 11:8, pages 990-992.
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R. A. Corley, M. J. Bartels, E. W. Carney, K. K. Weitz, J. J. Soelberg, R. A. Gies & K. D. Thrall. (2005) Development of a Physiologically Based Pharmacokinetic Model for Ethylene Glycol and Its Metabolite, Glycolic Acid, in Rats and Humans. Toxicological Sciences 85:1, pages 476-490.
Crossref
Robert Hess, Michael J. Bartels & Lynn H. Pottenger. (2004) Ethylene glycol: an estimate of tolerable levels of exposure based on a review of animal and human data. Archives of Toxicology 78:12, pages 671-680.
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