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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 9
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Research Article

Oxidation and rearrangements of flavanones by mammalian cytochrome P450

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Pages 797-810 | Received 20 Apr 2004, Published online: 22 Sep 2008

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Read on this site (4)

Haruna Nagayoshi, Norie Murayama, Shigeo Takenaka, Vitchan Kim, Donghak Kim, Masayuki Komori, Hiroshi Yamazaki, F. Peter Guengerich & Tsutomu Shimada. (2021) Roles of cytochrome P450 2A6 in the oxidation of flavone, 4′-hydroxyflavone, and 4′-, 3′-, and 2′-methoxyflavones by human liver microsomes. Xenobiotica 51:9, pages 995-1009.
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Tsutomu Shimada, Haruna Nagayoshi, Norie Murayama, Shigeo Takenaka, Jun Katahira, Vitchan Kim, Donghak Kim, Masayuki Komori, Hiroshi Yamazaki & F. Peter Guengerich. (2021) Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2′-, 3′-, 4′- and 6-hydroxyflavanones by human cytochrome P450 enzymes. Xenobiotica 51:2, pages 139-154.
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Haruna Nagayoshi, Norie Murayama, Kensaku Kakimoto, Shigeo Takenaka, Jun Katahira, Young-Ran Lim, Vitchan Kim, Donghak Kim, Hiroshi Yamazaki, Masayuki Komori, F. Peter Guengerich & Tsutomu Shimada. (2019) Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes. Xenobiotica 49:7, pages 791-802.
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Kensaku Kakimoto, Norie Murayama, Shigeo Takenaka, Haruna Nagayoshi, Young-Ran Lim, Vitchan Kim, Donghak Kim, Hiroshi Yamazaki, Masayuki Komori, F. Peter Guengerich & Tsutomu Shimada. (2019) Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone. Xenobiotica 49:2, pages 131-142.
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Articles from other publishers (13)

Haruna Nagayoshi, Norie Murayama, Vitchan Kim, Donghak Kim, Shigeo Takenaka, Hiroshi Yamazaki, F. Peter Guengerich & Tsutomu Shimada. (2023) Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1. Chemical Research in Toxicology 36:11, pages 1778-1788.
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Pradeep Subedi, Jong Kook Park & Tae-Jin Oh. (2022) Engineering of Microbial Substrate Promiscuous CYP105A5 for Improving the Flavonoid Hydroxylation. Catalysts 12:10, pages 1157.
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Florian Puls, Felix Seewald, Vadim Grinenko, Hans‐Henning Klauß & Hans‐Joachim Knölker. (2021) Mechanistic Studies on the Hexadecafluorophthalocyanine–Iron‐Catalyzed Wacker‐Type Oxidation of Olefins to Ketones**. Chemistry – A European Journal 27:67, pages 16776-16787.
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Anna Boronat, Jose Rodriguez-Morató, Gabriele Serreli, Montserrat Fitó, Rachel F Tyndale, Monica Deiana & Rafael de la Torre. (2021) Contribution of Biotransformations Carried Out by the Microbiota, Drug-Metabolizing Enzymes, and Transport Proteins to the Biological Activities of Phytochemicals Found in the Diet. Advances in Nutrition 12:6, pages 2172-2189.
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Haruna Nagayoshi, Norie Murayama, Kensaku Kakimoto, Masaki Tsujino, Shigeo Takenaka, Jun Katahira, Young-Ran Lim, Donghak Kim, Hiroshi Yamazaki, Masayuki Komori, F. Peter Guengerich & Tsutomu Shimada. (2019) Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes. Chemical Research in Toxicology 32:6, pages 1268-1280.
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Yasushi Yamazoe & Kouichi Yoshinari. (2017) Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 2: Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system. Drug Metabolism and Pharmacokinetics 32:5, pages 229-247.
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Tomohide Uno, Chika Ogura, Chiho Izumi, Masahiko Nakamura, Takeshi Yanase, Hiroshi Yamazaki, Hitoshi Ashida, Kengo Kanamaru, Hiroshi Yamagata & Hiromasa Imaishi. (2015) Point mutation of cytochrome P450 2A6 (a polymorphic variant CYP2A6.25) confers new substrate specificity towards flavonoids. Biopharmaceutics & Drug Disposition 36:8, pages 552-563.
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Tomohide Uno, Yuichiro Obe, Chika Ogura, Tatsushi Goto, Kohei Yamamoto, Masahiko Nakamura, Kengo Kanamaru, Hiroshi Yamagata & Hiromasa Imaishi. (2012) Metabolism of 7‐ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants. Biopharmaceutics & Drug Disposition 34:2, pages 87-97.
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Mariana C. Sousa, Rodolpho C. Braga, Bertilha A.S. Cintra, Valéria de Oliveira & Carolina H. Andrade. (2013) In silico metabolism studies of dietary flavonoids by CYP1A2 and CYP2C9. Food Research International 50:1, pages 102-110.
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Paul R. Ortiz de Montellano & Sidney D. Nelson. (2011) Rearrangement reactions catalyzed by cytochrome P450s. Archives of Biochemistry and Biophysics 507:1, pages 95-110.
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Sam Possemiers, Willy Verstraete & Tom Van de Wiele. 2009. Beer in Health and Disease Prevention. Beer in Health and Disease Prevention 523 539 .
Shin-ichi Ayabe & Tomoyoshi Akashi. (2006) Cytochrome P450s in flavonoid metabolism. Phytochemistry Reviews 5:2-3, pages 271-282.
Crossref
Hitoshi Kagawa, Asako Shigematsu, Shigeru Ohta & Yoshihiro Harigaya. (2005) Preparative Monohydroxyflavanone Syntheses and a Protocol for Gas Chromatography-Mass Spectrometry Analysis of Monohydroxyflavanones. Chemical and Pharmaceutical Bulletin 53:5, pages 547-554.
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