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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 11-12
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Research Article

Use of a cocktail of probe substrates for drug-metabolizing enzymes for the assessment of the metabolic capacity of hepatocyte preparations

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Pages 949-959 | Received 15 Jul 2004, Published online: 22 Sep 2008

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Read on this site (5)

Anna-Karin Sohlenius-Sternbeck, Urban Fagerholm & Johan Bylund. (2013) The volume of distribution is an indicator of poor in vitro–in vivo extrapolation of clearance for acidic drugs in the rat. Xenobiotica 43:8, pages 671-678.
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Brigitte Gerin, Sylvie Dell’Aiera, Lysiane Richert, Steven Smith & Hugues Chanteux. (2013) Assessment of cytochrome P450 (1A2, 2B6, 2C9 and 3A4) induction in cryopreserved human hepatocytes cultured in 48-well plates using the cocktail strategy. Xenobiotica 43:4, pages 320-335.
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Anna-Karin Sohlenius-Sternbeck, Christopher Jones, Douglas Ferguson, Brian J. Middleton, Denis Projean, Eva Floby, Johan Bylund & Lovisa Afzelius. (2012) Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes. Xenobiotica 42:9, pages 841-853.
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E. Floby, J. Johansson, J. Hoogstraate, N. J. Hewitt, J. Hill & A.-K. Sohlenius-Sternbeck. (2009) Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes. Xenobiotica 39:9, pages 656-662.
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A.-K. Sohlenius-Sternbeck & S. Schmidt. (2005) Impaired glutathione-conjugating capacity by cryopreserved human and rat hepatocytes. Xenobiotica 35:7, pages 727-736.
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Articles from other publishers (13)

Xin Chen, Fuxing Hao, Meng Zhang, Jinzha Xiao, Weiya Zhao, Zeting Zhao & Yumei Zhang. (2021) Sex Metabolic Differences and Effects on Blood Coagulation Among Rats Exposed to Sodium Dehydroacetate. Frontiers in Pharmacology 12.
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Susanna Eketjäll, Juliette Janson, Karin Kaspersson, Anna Bogstedt, Fredrik Jeppsson, Johanna Fälting, Samantha Budd Haeberlein, Alan R. Kugler, Robert C. Alexander & Gvido Cebers. (2016) AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics. Journal of Alzheimer's Disease 50:4, pages 1109-1123.
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Varvara Gouliarmou, Olavi Pelkonen & Sandra Coecke. 2015. Protocols in In Vitro Hepatocyte Research. Protocols in In Vitro Hepatocyte Research 143 159 .
Dany Spaggiari, Laurent Geiser, Youssef Daali & Serge Rudaz. (2014) A cocktail approach for assessing the in vitro activity of human cytochrome P450s: An overview of current methodologies. Journal of Pharmaceutical and Biomedical Analysis 101, pages 221-237.
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Zihao Hua, Howard Bregman, John L. Buchanan, Nagasree Chakka, Angel Guzman-Perez, Hakan Gunaydin, Xin Huang, Yan Gu, Virginia Berry, Jingzhou Liu, Yohannes Teffera, Liyue Huang, Bryan Egge, Renee Emkey, Erin L. Mullady, Steve Schneider, Paul S. Andrews, Lisa Acquaviva, Jennifer Dovey, Ankita Mishra, John Newcomb, Douglas Saffran, Randy Serafino, Craig A. Strathdee, Susan M. Turci, Mary Stanton, Cindy Wilson & Erin F. DiMauro. (2013) Development of Novel Dual Binders as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors. Journal of Medicinal Chemistry 56:24, pages 10003-10015.
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Britt-Marie Swahn, Karin Kolmodin, Sofia Karlström, Stefan von Berg, Peter Söderman, Jörg Holenz, Stefan Berg, Johan Lindström, Marie Sundström, Dominika Turek, Jacob Kihlström, Can Slivo, Lars Andersson, David Pyring, Didier Rotticci, Liselotte Öhberg, Annika Kers, Krisztian Bogar, Fredrik von Kieseritzky, Margareta Bergh, Lise-Lotte Olsson, Juliette Janson, Susanna Eketjäll, Biljana Georgievska, Fredrik Jeppsson & Johanna Fälting. (2012) Design and Synthesis of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β-Amyloid Peptides. Journal of Medicinal Chemistry 55:21, pages 9346-9361.
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V. A. Sukhanov & L. A. Piruzyan. (2010) Role of physiological factors in predicting the risk of oncological diseases on the basis of the polymorphism of the xenobiotic metabolism enzyme system. Human Physiology 36:6, pages 723-736.
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Paulo Paixão, Luís F. Gouveia & José A.G. Morais. (2010) Prediction of the in vitro intrinsic clearance determined in suspensions of human hepatocytes by using artificial neural networks. European Journal of Pharmaceutical Sciences 39:5, pages 310-321.
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Urban Fagerholm. (2007) Prediction of human pharmacokinetics—evaluation of methods for prediction of hepatic metabolic clearance. Journal of Pharmacy and Pharmacology 59:6, pages 803-828.
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Giovanni Tarantino, Matteo Nicola Dario Di Minno & Domenico Capone. (2009) Drug-induced liver injury: Is it somehow foreseeable?. World Journal of Gastroenterology 15:23, pages 2817.
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Agustín Lahoz, Maria Teresa Donato, Sandra Montero, José V. Castell & Maria José Gómez-Lechón. (2008) A new in vitro approach for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations . Rapid Communications in Mass Spectrometry 22:2, pages 240-244.
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Wenkui Li, Suyi Luo, Harold T. Smith & Francis L. S. Tse. (2007) Simultaneous determination of midazolam and 1′‐hydroxymidazolam in human plasma by liquid chromatography with tandem mass spectrometry. Biomedical Chromatography 21:8, pages 841-851.
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Hyojin Kim, Yune -Jung Yoon, Hyunmi Kim, Eun -Young Cha, Hye Suk Lee, Jeong -Han Kim, Kyu Yang Yi, Sunkyung Lee, Hyae Gyeong Cheon, Sung -Eun Yoo, Sang -Seop Lee, Jae -Gook Shin & Kwang -Hyeon Liu. (2005) In vitro metabolism of a new cardioprotective agent, KR-33028 in the human liver microsomes and cryopreserved human hepatocytes. Archives of Pharmacal Research 28:11, pages 1287-1292.
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