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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 1
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Research Article

Metabolism of benzamidoxime (N-hydroxyamidine) in human hepatocytes and role of UDP-glucuronosyltransferases

A. K. Fröhlich Pharmaceutical Institute, Christian-Albrechts-University of Kiel, Kiel, Germany
,
U. Girreser Pharmaceutical Institute, Christian-Albrechts-University of Kiel, Kiel, Germany
&
B Clement Pharmaceutical Institute, Christian-Albrechts-University of Kiel, Kiel, GermanyCorrespondence[email protected]
Pages 17-25 | Received 27 Aug 2004, Published online: 22 Sep 2008

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Jinping Gan, Shuguang Ma & Donglu Zhang. (2016) Non-cytochrome P450-mediated bioactivation and its toxicological relevance. Drug Metabolism Reviews 48:4, pages 473-501.
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S. K. Lee, D. W. Lee, T. W. Jeon, C. H. Jin, G. H. Kim, I. H. Jun, D. J. Lee, S.-I. Kim, D.-H. Kim, Y. Jahng & T. C. Jeong. (2005) Characterization of the Phase II metabolites of rutaecarpine in rat by liquid chromatography-electrospray ionization-tandem mass spectrometry. Xenobiotica 35:12, pages 1135-1145.
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Naunpun Sangphech, Chanin Sillapachaiyaporn, Sunita Nilkhet & Siriporn Chuchawankul. (2021) Auricularia polytricha ethanol crude extract from sequential maceration induces lipid accumulation and inflammatory suppression in RAW264.7 macrophages . Food & Function 12:21, pages 10563-10570.
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Eddy W. Yue, Richard Sparks, Padmaja Polam, Dilip Modi, Brent Douty, Brian Wayland, Brian Glass, Amy Takvorian, Joseph Glenn, Wenyu Zhu, Michael Bower, Xiangdong Liu, Lynn Leffet, Qian Wang, Kevin J. Bowman, Michael J. Hansbury, Min Wei, Yanlong Li, Richard Wynn, Timothy C. Burn, Holly K. Koblish, Jordan S. Fridman, Tom Emm, Peggy A. Scherle, Brian Metcalf & Andrew P. Combs. (2017) INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology. ACS Medicinal Chemistry Letters 8:5, pages 486-491.
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J. Boer, R. Young-Sciame, F. Lee, K. J. Bowman, X. Yang, J. G. Shi, F. M. Nedza, W. Frietze, L. Galya, A. P. Combs, S. Yeleswaram & S. Diamond. (2016) Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans. Drug Metabolism and Disposition 44:10, pages 1668-1674.
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Jiang-Ran LI, Min-Jie SUN, Qi-Neng Ping, Xi-Jing CHEN, Jian-Ping QI & De-En HAN. (2010) Metabolism, Excretion and Bioavailability of Hydroxysafflor Yellow A after Oral Administration of Its Lipid-Based Formulation and Aqueous Solution in Rats. Chinese Journal of Natural Medicines 8:3, pages 233-240.
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Masahiko Uchida, Kosuke Okazaki, Harunobu Mukaiyama, Hidetoshi Isawa, Hiroaki Kobayashi, Hiroaki Shiohara, Hideyuki Muranaka, Yuichiro Kai, Norihiko Kikuchi, Hideki Takeuchi, Kenji Yokoyama, Eiichi Tsuji, Tomonaga Ozawa, Yuji Hoyano, Takashi Koizumi, Keiko Misawa, Kiyoto Hara, Shigeru Nakano, Yasuoki Murakami & Hiroaki Okuno. (2008) Orally active factor Xa inhibitors: Investigation of a novel series of 3-amidinophenylsulfonamide derivatives using an amidoxime prodrug strategy. Bioorganic & Medicinal Chemistry Letters 18:16, pages 4682-4687.
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Christiane Reeh, Judith Wundt & Bernd Clement. (2007) N , N ′-Dihydroxyamidines: A New Prodrug Principle To Improve the Oral Bioavailability of Amidines . Journal of Medicinal Chemistry 50:26, pages 6730-6734.
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Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:3, pages 257-405.
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Sang Kyu Lee, Hye Gwang Jeong, Eung Seok Lee & Tae Cheon Jeong. (2007) Metabolism of FPP-3, an Anti-inflammatory Propenone Compound, in Rat by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry. Biological and Pharmaceutical Bulletin 30:5, pages 967-971.
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Antje Havemeyer, Florian Bittner, Silke Wollers, Ralf Mendel, Thomas Kunze & Bernd Clement. (2006) Identification of the Missing Component in the Mitochondrial Benzamidoxime Prodrug-converting System as a Novel Molybdenum Enzyme. Journal of Biological Chemistry 281:46, pages 34796-34802.
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Anja Kristina Froehlich, Ulrich Girreser & Bernd Clement. (2005) METABOLISM OF N -HYDROXYGUANIDINES ( N -HYDROXYDEBRISOQUINE) IN HUMAN AND PORCINE HEPATOCYTES: REDUCTION AND FORMATION OF GLUCURONIDES . Drug Metabolism and Disposition 33:10, pages 1532-1537.
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