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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 1
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Research Article

Stereoselective inhibition of cytochrome P450 forms by lansoprazole and omeprazole in vitro

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Pages 27-38 | Received 09 Aug 2004, Published online: 22 Sep 2008

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Ying Peng, Hui Wu, Xueyuan Zhang, Fengyi Zhang, Huanhuan Qi, Yunxi Zhong, Yu Wang, Hua Sang, Guangji Wang & Jianguo Sun. (2015) A comprehensive assay for nine major cytochrome P450 enzymes activities with 16 probe reactions on human liver microsomes by a single LC/MS/MS run to support reliable in vitro inhibitory drug–drug interaction evaluation. Xenobiotica 45:11, pages 961-977.
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ChristopherS. Mazur, JohnF. Kenneke, Caroline Tebes-Stevens, MilesS. Okino & JohnC. Lipscomb. (2007) In Vitro Metabolism of the Fungicide and Environmental Contaminant trans-bromuconazole and Implications for Risk Assessment. Journal of Toxicology and Environmental Health, Part A 70:14, pages 1241-1250.
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James J Cali, Dongping Ma, Mary Sobol, Daniel J Simpson, Susan Frackman, Troy D Good, William J Daily & David Liu. (2006) Luminogenic cytochrome P450 assays. Expert Opinion on Drug Metabolism & Toxicology 2:4, pages 629-645.
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Ayako Watanabe, Kenji Momo, Katsumi Tanaka, Takeshi Uchikura, Yoshihiro Kiryu, Kanami NiiyamaNorihisa KodairaAiri Matsuzaki & Tadanori Sasaki. (2022) Identification of the Components of Proton Pump Inhibitors and Potassium-Competitive Acid Blocker That Lead to Cardiovascular Events in Working-Age Individuals: A 12-Month Retrospective Cohort Study Using a Large Claims Database. Biological and Pharmaceutical Bulletin 45:9, pages 1373-1377.
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Fausto Meriggi. (2021) Controversial link between proton pump inhibitors and anticancer agents: review of the literature. Tumori Journal 108:3, pages 204-212.
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Nanyong Gao, Xiaodan Zhang, Xiaoqin Hu, Qihui Kong, Jianping Cai, Guoxin Hu & Jianchang Qian. (2022) The Influence of CYP3A4 Genetic Polymorphism and Proton Pump Inhibitors on Osimertinib Metabolism. Frontiers in Pharmacology 13.
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Prajakta Harish Patil, Puralae Channabasavaiah Jagadish, Fajeelath Fatima, Sumit Birangal, Gurupur Gautham Shenoy, Mahadev Rao, Junaid Farooqui, Himanshu Rastogi, Tarun Sharma & Jakir Pinjari. (2022) Inhibition of Cytochrome P450 Enzyme and Drug-Drug Interaction Potential of Acid Reducing Agents Used in Management of CDK Inhibitors for Breast Cancer Chemotherapy. Current Drug Metabolism 23:2, pages 137-149.
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Tobias Kanacher, Andreas Lindauer, Enrica Mezzalana, Ingrid Michon, Celine Veau, Jose David Gómez Mantilla, Valerie Nock & Angèle Fleury. (2020) A Physiologically-Based Pharmacokinetic (PBPK) Model Network for the Prediction of CYP1A2 and CYP2C19 Drug–Drug–Gene Interactions with Fluvoxamine, Omeprazole, S-mephenytoin, Moclobemide, Tizanidine, Mexiletine, Ethinylestradiol, and Caffeine. Pharmaceutics 12:12, pages 1191.
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Hyun‐Ji Kim, Hyunyoung Lee, Hyeon‐Kyeong Ji, Taeho Lee & Kwang‐Hyeon Liu. (2019) Screening of ten cytochrome P450 enzyme activities with 12 probe substrates in human liver microsomes using cocktail incubation and liquid chromatography–tandem mass spectrometry. Biopharmaceutics & Drug Disposition 40:3-4, pages 101-111.
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Laura Costarelli, Robertina Giacconi, Marco Malavolta, Andrea Basso, Francesco Piacenza, Mauro Provinciali, Marcello G. Maggio, Andrea Corsonello & Fabrizia Lattanzio. (2016) Different transcriptional profiling between senescent and non-senescent human coronary artery endothelial cells (HCAECs) by Omeprazole and Lansoprazole treatment. Biogerontology 18:2, pages 217-236.
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Amalie Møller Sørensen, Cecilie Hurup Hansen, Silvia Bonomo, Lars Olsen, Flemming Steen Jørgensen, Johan Juhl Weisser, Andreas Christopher Kretschmann & Bjarne Styrishave. (2016) Enantioselective endocrine disrupting effects of omeprazole studied in the H295R cell assay and by molecular modeling. Toxicology in Vitro 34, pages 71-80.
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Barbara Ring, Steven A. Wrighton & Michael Mohutsky. 2014. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 37 56 .
D. E. Moody, F. Liu & W. B. Fang. (2013) In vitro Inhibition of Methadone and Oxycodone Cytochrome P450-Dependent Metabolism: Reversible Inhibition by H2-Receptor Agonists and Proton-Pump Inhibitors. Journal of Analytical Toxicology 37:8, pages 476-485.
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Eun-Jung Choi, Yin-Jin Jang, Eun-Young Cha, Jae-Gook Shin & Sang Seop Lee. (2013) Identification and Characterization of Novel Alternative Splice Variants of Human Constitutive Androstane Receptor in Liver Samples of Koreans and Caucasians. Drug Metabolism and Disposition 41:4, pages 888-896.
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Tatyana Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang, Ragini Vuppugalla, Jeremy Hurley, Denise Thorndike, Andrew Wagner, Anjaneya Chimalakonda & A. David Rodrigues. (2012) Evaluation of Six Proton Pump Inhibitors As Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19. Drug Metabolism and Disposition 40:9, pages 1698-1711.
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Yan Pan, Kai Hung Tiong, Badrul Amini Abd-Rashid, Zakiah Ismail, Rusli Ismail, Joon Wah Mak & Chin Eng Ong. (2012) Inhibitory effects of cytochrome P450 enzymes CYP2C8, CYP2C9, CYP2C19 and CYP3A4 by Labisia pumila extracts. Journal of Ethnopharmacology 143:2, pages 586-591.
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Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn & Fabrice Hurbin. (2012) Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite. Drug Metabolism and Disposition 40:1, pages 187-197.
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Wenjie Jessie Lu, Valentina Ferlito, Cong Xu, David Alastair Flockhart & Salvatore Caccamese. (2011) Enantiomers of naringenin as pleiotropic, stereoselective inhibitors of cytochrome P450 isoforms. Chirality 23:10, pages 891-896.
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James M. Mullin, Melissa Gabello, Lisa J. Murray, Christopher P. Farrell, Jillan Bellows, Kevin R. Wolov, Keith R. Kearney, David Rudolph & James J. Thornton. (2009) Proton pump inhibitors: actions and reactions. Drug Discovery Today 14:13-14, pages 647-660.
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Kyung-Ah Seo, Hyunmi Kim, Hei-Young Ku, Hee-Jeong Ahn, Soo-Jin Park, Soo Kyung Bae, Jae-Gook Shin & Kwang-Hyeon Liu. (2008) The monoterpenoids citral and geraniol are moderate inhibitors of CYP2B6 hydroxylase activity. Chemico-Biological Interactions 174:3, pages 141-146.
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Hortensia Alonso-Navarro, Félix J. Jiménez-Jiménez & José A. García-Agúndez. (2006) Papel del polimorfismo genético CYP2C19 en los efectos adversos a fármacos y en el riesgo para diversas enfermedades. Medicina Clínica 126:18, pages 697-706.
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