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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 2
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Research Article

Glucuronidation of bioflavonoids by human UGT1A10: structure–function relationships

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Pages 117-129 | Received 27 Sep 2004, Published online: 22 Sep 2008

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Read on this site (6)

Gerard Bryan Gonzales, Guy Smagghe, Charlotte Grootaert, Moises Zotti, Katleen Raes & John Van Camp. (2015) Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure–activity/property relationship-based approach in the study of bioavailability and bioactivity. Drug Metabolism Reviews 47:2, pages 175-190.
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Dong Gui Hu, Robyn Meech, Ross A. McKinnon & Peter I. Mackenzie. (2014) Transcriptional regulation of human UDP-glucuronosyltransferase genes. Drug Metabolism Reviews 46:4, pages 421-458.
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Satya Prakash Tripathi, Anuseema Bhadauriya, Abhijeet Patil & Abhay T. Sangamwar. (2013) Substrate selectivity of human intestinal UDP-glucuronosyltransferases (UGTs): in silico and in vitro insights. Drug Metabolism Reviews 45:2, pages 231-252.
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Petra Jančová, Michal Šiller, Eva Anzenbacherová, Vladimír Křen, Pavel Anzenbacher & Vilím Šimánek. (2011) Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases. Xenobiotica 41:9, pages 743-751.
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Yin Cheong Wong, Li Zhang, Ge Lin & Zhong Zuo. (2009) Structure–activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases. Expert Opinion on Drug Metabolism & Toxicology 5:11, pages 1399-1419.
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Articles from other publishers (17)

Micaela B. Reddy, Michael B. Bolger, Grace Fraczkiewicz, Laurence Del Frari, Laibin Luo, Viera Lukacova, Amitava Mitra, Joyce S. Macwan, Jim M. Mullin, Neil Parrott & Aki T. Heikkinen. (2021) PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates. Pharmaceutics 13:9, pages 1325.
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Lili Gan, Jiating Ma, Guoquan You, Jinxia Mai, Zhaoyu Wang, Ruopeng Yang, Cong Xie, Jingrao Fei, Lan Tang, Jie Zhao, Zheng Cai & Ling Ye. (2020) Glucuronidation and its effect on the bioactivity of amentoflavone, a biflavonoid from Ginkgo biloba leaves . Journal of Pharmacy and Pharmacology 72:12, pages 1840-1853.
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Robyn Meech, Dong Gui Hu, Ross A. McKinnon, Siti Nurul Mubarokah, Alex Z. Haines, Pramod C. Nair, Andrew Rowland & Peter I. Mackenzie. (2019) The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms. Physiological Reviews 99:2, pages 1153-1222.
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Vaibhav A. Dixit, L. Arun Lal & Simran R. Agrawal. (2017) Recent advances in the prediction of non‐ CYP450 ‐mediated drug metabolism . WIREs Computational Molecular Science 7:6.
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Shingo Oda, Yukiko Kato, Masahiko Hatakeyama, Atsushi Iwamura, Tatsuki Fukami, Toshiyuki Kume, Tsuyoshi Yokoi & Miki Nakajima. (2017) Evaluation of Expression and Glycosylation Status of UGT1A10 in Supersomes and Intestinal Epithelial Cells with a Novel Specific UGT1A10 Monoclonal Antibody. Drug Metabolism and Disposition 45:9, pages 1027-1034.
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Shingo Oda, Tatsuki Fukami, Tsuyoshi Yokoi & Miki Nakajima. (2015) A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development. Drug Metabolism and Pharmacokinetics 30:1, pages 30-51.
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Dong Dong & Baojian Wu. (2012) In Silico Modeling of UDP-Glucuronosyltransferase 1A10 Substrates Using the Volsurf Approach. Journal of Pharmaceutical Sciences 101:9, pages 3531-3539.
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Wen Jiang & Ming Hu. (2012) Mutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways. RSC Advances 2:21, pages 7948.
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Keigo Kosaka, Norifumi Sakai, Yuya Endo, Yuga Fukuhara, Minoru Tsuda-Tsukimoto, Tatsuyuki Ohtsuka, Ichiro Kino, Tomohiko Tanimoto, Naomi Takeba, Masakatsu Takahashi & Toshiyuki Kume. (2011) Impact of Intestinal Glucuronidation on the Pharmacokinetics of Raloxifene. Drug Metabolism and Disposition 39:9, pages 1495-1502.
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Shenggu Xie, Yakun Chen, Shuqing Chen & Su Zeng. (2011) Structure–metabolism relationships for the glucuronidation of flavonoids by UGT1A3 and UGT1A9. Journal of Pharmacy and Pharmacology 63:2, pages 297-304.
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Petra Jancova, Pavel Anzenbacher & Eva Anzenbacherova. (2010) PHASE II DRUG METABOLIZING ENZYMES. Biomedical Papers 154:2, pages 103-116.
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Yin Cheong Wong, Li Zhang, Ge Lin & Zhong Zuo. (2009) Intestinal first-pass glucuronidation activities of selected dihydroxyflavones. International Journal of Pharmaceutics 366:1-2, pages 14-20.
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Bernard Testa & Stefanie D. Krämer. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:11, pages 2171-2336.
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David E. Stevenson, Janine M. Cooney, Dwayne J. Jensen, Reginald Wibisono, Aselle Adaim, Margot A. Skinner & Jingli Zhang. (2008) Comparison of enzymically glucuronidated flavonoids with flavonoid aglycones in an in vitro cellular model of oxidative stress protection. In Vitro Cellular & Developmental Biology - Animal 44:3-4, pages 73-80.
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Athena Starlard-Davenport, Beverly Lyn-Cook & Anna Radominska-Pandya. (2008) Novel identification of UDP-glucuronosyltransferase 1A10 as an estrogen-regulated target gene. Steroids 73:1, pages 139-147.
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Li Zhang, Zhong Zuo & Ge Lin. (2007) Intestinal and Hepatic Glucuronidation of Flavonoids. Molecular Pharmaceutics 4:6, pages 833-845.
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Kathrin Kahle, Wolfgang Huemmer, Michael Kempf, Wolfgang Scheppach, Thomas Erk & Elke Richling. (2007) Polyphenols Are Intensively Metabolized in the Human Gastrointestinal Tract after Apple Juice Consumption. Journal of Agricultural and Food Chemistry 55:26, pages 10605-10614.
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