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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 3
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Research Article

Identification of cytochrome P450 enzymes involved in the metabolism of 3′,4′-methylenedioxy-α-pyrrolidinopropiophenone (MDPPP), a designer drug, in human liver microsomes

D Springer Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Saarland, D-66421 Homburg (Saar), Germany
,
R. F Staack Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Saarland, D-66421 Homburg (Saar), Germany
,
L. D Paul Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Saarland, D-66421 Homburg (Saar), Germany
,
T Kraemer Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Saarland, D-66421 Homburg (Saar), Germany
&
H. H Maurer Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Saarland, D-66421 Homburg (Saar), GermanyCorrespondence[email protected]
Pages 227-237 | Received 11 Oct 2004, Published online: 22 Sep 2008

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João L. Gonçalves, Vera L. Alves, Joselin Aguiar, Helena M. Teixeira & José S. Câmara. (2019) Synthetic cathinones: an evolving class of new psychoactive substances. Critical Reviews in Toxicology 49:7, pages 549-566.
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Arthur F.V.F. Reis, Igor L.P. Gonçalves, Abel F.G. Neto, Alberdan S. Santos, Kamil Kuca, Eugenie Nepovimova & Antonio M.J.C. Neto. (2018) Intermolecular interactions between DNA and methamphetamine, amphetamine, ecstasy and their major metabolites. Journal of Biomolecular Structure and Dynamics 36:12, pages 3047-3057.
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Kayla N. Ellefsen, Marta Concheiro & Marilyn A. Huestis. (2016) Synthetic cathinone pharmacokinetics, analytical methods, and toxicological findings from human performance and postmortem cases. Drug Metabolism Reviews 48:2, pages 237-265.
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Articles from other publishers (11)

Jorge Soares, Vera Marisa Costa, Maria de Lourdes Bastos, Félix Carvalho & João Paulo Capela. (2021) An updated review on synthetic cathinones. Archives of Toxicology 95:9, pages 2895-2940.
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Lilian H.J. Richter, Veit Flockerzi, Hans H. Maurer & Markus R. Meyer. (2017) Pooled human liver preparations, HepaRG, or HepG2 cell lines for metabolism studies of new psychoactive substances? A study using MDMA, MDBD, butylone, MDPPP, MDPV, MDPB, 5-MAPB, and 5-API as examples. Journal of Pharmaceutical and Biomedical Analysis 143, pages 32-42.
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Markus R. Meyer & Hans H. Maurer. 2016. Forensic Toxicology: Drug Use and Misuse. Forensic Toxicology: Drug Use and Misuse 519 534 .
Elli Tyrkkö, Mikael Andersson & Robert Kronstrand. (2016) The Toxicology of New Psychoactive Substances. Therapeutic Drug Monitoring 38:2, pages 190-216.
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Madeleine J Swortwood, Jeremy Carlier, Kayla N Ellefsen, Ariane Wohlfarth, Xingxing Diao, Marta Concheiro-Guisan, Robert Kronstrand & Marilyn A Huestis. (2016) In vitro, in vivo and in silico metabolic profiling of α-pyrrolidinopentiothiophenone, a novel thiophene stimulant . Bioanalysis 8:1, pages 65-82.
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Markus R. Meyer, Sandra Mauer, Golo M. J. Meyer, Julia Dinger, Birgit Klein, Folker Westphal & Hans H. Maurer. (2014) The in vivo and in vitro metabolism and the detectability in urine of 3’,4’-methylenedioxy-alpha-pyrrolidinobutyrophenone (MDPBP), a new pyrrolidinophenone-type designer drug, studied by GC-MS and LC-MS n . Drug Testing and Analysis 6:7-8, pages 746-756.
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Maria João Valente, Paula Guedes de Pinho, Maria de Lourdes Bastos, Félix Carvalho & Márcia Carvalho. (2013) Khat and synthetic cathinones: a review. Archives of Toxicology 88:1, pages 15-45.
Crossref
Markus R. Meyer & Hans H. Maurer. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics 429 463 .
Frank T. Peters & Markus R. Meyer. (2011) In vitro approaches to studying the metabolism of new psychoactive compounds. Drug Testing and Analysis 3:7-8, pages 483-495.
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Markus R. Meyer, Peng Du, Frank Schuster & Hans H. Maurer. (2010) Studies on the metabolism of the α-pyrrolidinophenone designer drug methylenedioxy-pyrovalerone (MDPV) in rat and human urine and human liver microsomes using GC-MS and LC-high-resolution MS and its detectability in urine by GC-MS. Journal of Mass Spectrometry 45:12, pages 1426-1442.
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Denis S. Theobald & Hans H. Maurer. (2007) Identification of monoamine oxidase and cytochrome P450 isoenzymes involved in the deamination of phenethylamine-derived designer drugs (2C-series). Biochemical Pharmacology 73:2, pages 287-297.
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