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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 4
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Research Article

Comparative disposition of [14C]ertapenem, a novel carbapenem antibiotic, in rat, monkey and man

B. K. Wong Department of Drug Metabolism, Merck Research Laboratories, PO Box 4, West Point, PA 19486, USACorrespondence[email protected]
,
X. Xu Department of Drug Metabolism, Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA
,
S. Yu Department of Drug Metabolism, Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA
,
J. H. Lin Department of Drug Metabolism, Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA
,
R. Singh Department of Drug Metabolism, Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA
,
Y. Sahly Department of Drug Metabolism, Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA
,
G. Mistry Department of Clinical Pharmacology, Merck Research Laboratories, Rahway, NJ, USA
,
S. Holland Department of Clinical Pharmacology, Merck Research Laboratories, Rahway, NJ, USA
,
S. Waldman Department of Clinical Pharmacology, Thomas Jefferson University, Philadelphia, PA, USA
,
D. Musson Department of Drug Metabolism, Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA
&
A. Majumdar Department of Drug Metabolism, Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA
 show all
Pages 379-389 | Received 06 Nov 2003, Published online: 22 Sep 2008

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Konstantinos Z. Vardakas, Georgios D. Kalimeris, Nikolaos A. Triarides & Matthew E. Falagas. (2018) An update on adverse drug reactions related to β-lactam antibiotics. Expert Opinion on Drug Safety 17:5, pages 499-508.
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Dominique Breilh, Jeannette Texier-Maugein, Bernard Allaouchiche, Marie-Claude Saux & Emmanuel Boselli. (2013) Carbapenems. Journal of Chemotherapy 25:1, pages 1-17.
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Annika Samuelsson, Barbro Isaksson, Jon Jonasson, Lennart E. Nilsson, Olle Eriksson, Håkan Hanberger & Abbas Chabok. (2012) Changes in the aerobic faecal flora of patients treated with antibiotics for acute intra-abdominal infection. Scandinavian Journal of Infectious Diseases 44:11, pages 820-827.
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Philippe Lagacé-Wiens & Ethan Rubinstein. (2012) Adverse reactions to β-lactam antimicrobials. Expert Opinion on Drug Safety 11:3, pages 381-399.
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Olaf Burkhardt, Hartmut Derendorf & Tobias Welte. (2007) Ertapenem: the new carbapenem 5 years after first FDA licensing for clinical practice. Expert Opinion on Pharmacotherapy 8:2, pages 237-256.
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Sarah J. Roffey, R. Scott Obach, Jenny I. Gedge & Dennis A. Smith. (2007) What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs. Drug Metabolism Reviews 39:1, pages 17-43.
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G. Samonis, S. Maraki, K. Leventakos, A. M. Spanaki, A. Kateifidis, E. Galanakis, Y. Tselentis, M. E. Falagas & E. Mantadakis. (2006) Comparative effects of ertapenem, imipenem, and meropenem on the colonization of the gastrointestinal tract of mice by Candida albicans. Medical Mycology 44:3, pages 233-235.
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George G Zhanel, Christel Johanson, John M Embil, Ayman Noreddin, Alfred Gin, Lavern Vercaigne & Daryl J Hoban. (2005) Ertapenem: review of a new carbapenem. Expert Review of Anti-infective Therapy 3:1, pages 23-39.
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Articles from other publishers (13)

Huan Kuang, Yongqiang Yang, Huan Luo & Xiaoju Lv. (2023) The impact of three carbapenems at a single-day dose on intestinal colonization resistance against carbapenem-resistant Klebsiella pneumoniae . mSphere.
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Kariana E Rios, Daniel J Selig, Radmila Pavlovic, Yonas Alamneh, Chau Vuong, Robert John Nadeau, Kristina M Pannone, Jesse P Deluca, Joseph B Long, Venkatasivasai S Sajja, Stuart Tyner, Vlado Antonic, Derese Getnet & Alexander G Bobrov. (2023) Impact of Blast Overpressure on the Pharmacokinetics of Various Antibiotics in Sprague Dawley Rats. Military Medicine 188:Supplement_6, pages 271-279.
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Rindala Saliba, Assaf Mizrahi, Péan de Ponfilly Gauthier, Le Monnier Alban, Jean-Ralph Zahar & Benoît Pilmis. (2022) Antimicrobial Stewardship Program: Reducing Antibiotic’s Spectrum of Activity Is not the Solution to Limit the Emergence of Multidrug-Resistant Bacteria. Antibiotics 11:1, pages 70.
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Nadia O. Bamfo, Chelsea Hosey-Cojocari, Leslie Z. Benet & Connie M. Remsberg. (2021) Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans. Pharmaceutical Research 38:7, pages 1139-1156.
Crossref
Donald J. AbrahamSebastian A. Testero, Leticia I. Llarrull, Jed F. Fisher & Shahriar Mobashery. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 188 .
Lorenzo Proia, Adriana Anzil, Carles Borrego, Marinella Farrè, Marta Llorca, Josep Sanchis, Pierre Bogaerts, Jose Luis Balcázar & Pierre Servais. (2018) Occurrence and persistence of carbapenemases genes in hospital and wastewater treatment plants and propagation in the receiving river. Journal of Hazardous Materials 358, pages 33-43.
Crossref
J. Zhou, Z. Sulaiman, R. M. Llorin, K.-H. Hee, L. S.-U. Lee, D. C. Lye, D. A. Fisher & V. H. Tam. (2014) Pharmacokinetics of ertapenem in outpatients with complicated urinary tract infections. Journal of Antimicrobial Chemotherapy 69:9, pages 2517-2521.
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Audrey Boulamery, Am?lie Marsot, Bernard Bruguerolle & Nicolas Simon. (2014) Population pharmacokinetics of ertapenem in juvenile and old rats. Fundamental & Clinical Pharmacology 28:2, pages 144-150.
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George Samonis, Emmanouil Galanakis, Markos Ntaoukakis, Emmanouela Sarchianaki, Thomai Spathopoulou, Dimitra Dimopoulou, Diamantis P. Kofteridis & Sofia Maraki. (2012) Effects of carbapenems and their combination with amikacin on murine gut colonisation by Candida albicans . Mycoses 56:2, pages 105-109.
Crossref
Donald J. AbrahamSebastian A. Testero, Jed F. Fisher & Shahriar Mobashery. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 257 402 .
Iolanda Cirillo, Geert Mannens, Cor Janssen, Marc Vermeir, Filip Cuyckens, Daksha Desai-Krieger, Nicole Vaccaro, L. Mark Kao, Damayanthi Devineni, Rebecca Redman & Kenneth Turner. (2008) Disposition, Metabolism, and Excretion of [ 14 C]Doripenem after a Single 500-Milligram Intravenous Infusion in Healthy Men . Antimicrobial Agents and Chemotherapy 52:10, pages 3478-3483.
Crossref
Audrey Boulamery, Hafedh Marouani, Romain Guilhaumou, Emmanuelle Rocher, Nicolas Simon & Bernard Bruguerolle. (2008) Effects of hyperthermia on pharmacokinetics of ertapenem in rats. Fundamental & Clinical Pharmacology 22:3, pages 285-289.
Crossref
Gillian M Keating & Caroline M Perry. (2005) Ertapenem. Drugs 65:15, pages 2151-2178.
Crossref

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