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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 7
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Research Article

Prediction of differences in in vivo oral clearance of N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine monohydrochloride (NE-100) between extensive and poor metabolizers from in vitro metabolic data in human liver microsomes lacking CYP2D6 activity and recombinant CYPs

T. Yamamoto Department of Drug Metabolism, Medicinal Research Laboratory, Taisho Pharmaceutical Co., Ltd, 403, Yoshino-cho 1-chome, Kita-ku, Saitama-shi, Saitama 331-9530, JapanCorrespondence[email protected]
,
N. Hagima Department of Drug Metabolism, Medicinal Research Laboratory, Taisho Pharmaceutical Co., Ltd, 403, Yoshino-cho 1-chome, Kita-ku, Saitama-shi, Saitama 331-9530, Japan
,
M. Nakamura Department of Drug Metabolism, Medicinal Research Laboratory, Taisho Pharmaceutical Co., Ltd, 403, Yoshino-cho 1-chome, Kita-ku, Saitama-shi, Saitama 331-9530, Japan
,
Y. Kohno Department of Drug Metabolism, Medicinal Research Laboratory, Taisho Pharmaceutical Co., Ltd, 403, Yoshino-cho 1-chome, Kita-ku, Saitama-shi, Saitama 331-9530, Japan
,
K. Nagata Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki-Aoba, Aoba-ku, Sendai-shi, Miyagi 980-0845, Japan
&
Y. Yamazoe Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki-Aoba, Aoba-ku, Sendai-shi, Miyagi 980-0845, Japan
Pages 687-703 | Received 06 Jan 2004, Published online: 22 Sep 2008

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T. Yamamoto, H. Itoga, Y. Kohno, K. Nagata & Y. Yamazoe. (2005) Prediction of oral clearance from in vitro metabolic data using recombinant CYPs: Comparison among well-stirred, parallel-tube, distributed and dispersion models. Xenobiotica 35:6, pages 627-646.
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Masato Chiba, Yasuyuki Ishii & Yuichi Sugiyama. (2009) Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development. The AAPS Journal 11:2.
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Makiko Kusama, Kazuya Maeda, Koji Chiba, Akinori Aoyama & Yuichi Sugiyama. (2008) Prediction of the Effects of Genetic Polymorphism on the Pharmacokinetics of CYP2C9 Substrates from In Vitro Data. Pharmaceutical Research 26:4, pages 822-835.
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