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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 11-12
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Research Article

Characterization and quantification of metabolites of racemic ketoprofen excreted in urine following oral administration to man by 1H-NMR spectroscopy, directly coupled HPLC-MS and HPLC-NMR, and circular dichroism

E. Skordi Biological Chemistry, Sir Alexander Fleming Building, Imperial College London, South Kensington, London SW7 2AZ, UKCorrespondence[email protected]
,
I. D. Wilson Department of Drug Metabolism and Pharmacokinetics, AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, UK
,
J. C. Lindon Biological Chemistry, Sir Alexander Fleming Building, Imperial College London, South Kensington, London SW7 2AZ, UK
&
J. K. Nicholson Biological Chemistry, Sir Alexander Fleming Building, Imperial College London, South Kensington, London SW7 2AZ, UK
Pages 1075-1089 | Received 15 Mar 2004, Published online: 22 Sep 2008

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G. Cetin, O. Corum, D. D. Corum, O. Atik, F. Altan, E. Turk, I. O. Tekeli, H. E. Faki & K. Uney. (2022) Pharmacokinetics of intravenous meloxicam, ketoprofen and tolfenamic acid in chukar partridge (Alectoris chukar). British Poultry Science 63:1, pages 14-20.
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Suruchi Singh & Raja Roy. (2016) The application of absolute quantitative 1H NMR spectroscopy in drug discovery and development. Expert Opinion on Drug Discovery 11:7, pages 695-706.
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E. Skordi, I. D. Wilson, J. C. Lindon & J. K. Nicholson. (2005) Kinetic studies on the intramolecular acyl migration of β-1-O-acyl glucuronides: Application to the glucuronides of (R)- and (S)-ketoprofen, (R)- and (S)-hydroxy-ketoprofen metabolites, and tolmetin by 1H-NMR spectroscopy. Xenobiotica 35:7, pages 715-725.
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Mohammad Shafiq Mashal, Marie Nalin, Fabien Bevalot, Pierre Sallet, Jérôme Guitton & Christelle Machon. (2022) Simultaneous quantification of 19 nonsteroidal anti‐inflammatory drugs in oral fluid by liquid chromatography‐high resolution mass spectrometry: Application on ultratrail runner's oral fluid. Drug Testing and Analysis 14:4, pages 701-712.
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. 2020. ANSI/AAMI/ISO 10993-16:2017; Biological evaluation of medical devices—Part 16: Toxicokinetic study design for degradation products and leachables. ANSI/AAMI/ISO 10993-16:2017; Biological evaluation of medical devices—Part 16: Toxicokinetic study design for degradation products and leachables.
Huma Ilyas & Eric D. van Hullebusch. (2020) Performance comparison of different types of constructed wetlands for the removal of pharmaceuticals and their transformation products: a review. Environmental Science and Pollution Research 27:13, pages 14342-14364.
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Basuvannan Rangasamy, Devan Hemalatha, Chellappan Shobana, Bojan Nataraj & Mathan Ramesh. (2018) Developmental toxicity and biological responses of zebrafish (Danio rerio) exposed to anti-inflammatory drug ketoprofen. Chemosphere 213, pages 423-433.
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Alexander David James, Cyrille Marvalin, Alexandre Luneau, Axel Meissner & Gian Camenisch. (2017) Comparison of 19 F NMR and 14 C Measurements for the Assessment of ADME of BYL719 (Alpelisib) in Humans . Drug Metabolism and Disposition 45:8, pages 900-907.
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María Hijosa-Valsero, Carolina Reyes-Contreras, Carmen Domínguez, Eloy Bécares & Josep M. Bayona. (2016) Behaviour of pharmaceuticals and personal care products in constructed wetland compartments: Influent, effluent, pore water, substrate and plant roots. Chemosphere 145, pages 508-517.
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Estelle Larsson, Said al-Hamimi & Jan Åke Jönsson. (2014) Behaviour of nonsteroidal anti-inflammatory drugs and eight of their metabolites during wastewater treatment studied by hollow fibre liquid phase microextraction and liquid chromatography mass spectrometry. Science of The Total Environment 485-486, pages 300-308.
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Franck A. Atienzar, Eric I. Novik, Helga H. Gerets, Amit Parekh, Claude Delatour, Alvaro Cardenas, James MacDonald, Martin L. Yarmush & Stéphane Dhalluin. (2014) Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans. Toxicology and Applied Pharmacology 275:1, pages 44-61.
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Abdul E. Mutlib. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 31 .
Abdul Mutlib, Robert Espina, James Atherton, Jianyao Wang, Rasmy Talaat, JoAnn Scatina & Appavu Chandrasekaran. (2012) Alternate Strategies to Obtain Mass Balance without the Use of Radiolabeled Compounds: Application of Quantitative Fluorine ( 19 F) Nuclear Magnetic Resonance (NMR) Spectroscopy in Metabolism Studies . Chemical Research in Toxicology 25:3, pages 572-583.
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T. K. FOSSE, T. E. HORSBERG, H. A. HAGA, V. HORMAZABAL & B. RANHEIM. (2011) Enantioselective pharmacokinetics of ketoprofen in piglets: the significance of neonatal age. Journal of Veterinary Pharmacology and Therapeutics 34:2, pages 153-159.
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Asu Ziylan & Nilsun H. Ince. (2011) The occurrence and fate of anti-inflammatory and analgesic pharmaceuticals in sewage and fresh water: Treatability by conventional and non-conventional processes. Journal of Hazardous Materials 187:1-3, pages 24-36.
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Abdul Mutlib, Robert Espina, Karthick Vishwanathan, Kathlene Babalola, Zecheng Chen, Christoph Dehnhardt, Aranapakam Venkatesan, Tarek Mansour, Inder Chaudhary, Rasmy Talaat & JoAnn Scatina. (2011) Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery. Drug Metabolism and Disposition 39:1, pages 106-116.
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Giancarlo Marconi, Elisabetta Mezzina, Ilse Manet, Francesco Manoli, Barbara Zambelli & Sandra Monti. (2020) Stereoselective interaction of ketoprofen enantiomers with β-cyclodextrin: ground state binding and photochemistry. Photochemical & Photobiological Sciences 10:1, pages 48-59.
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Angus NR Nedderman & Pat Wright. (2010) Looking back through the MIST: a perspective of evolving strategies and key focus areas for metabolite safety analysis. Bioanalysis 2:7, pages 1235-1248.
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Ernest Marco-Urrea, Miriam Pérez-Trujillo, Carles Cruz-Morató, Gloria Caminal & Teresa Vicent. (2010) White-rot fungus-mediated degradation of the analgesic ketoprofen and identification of intermediates by HPLC–DAD–MS and NMR. Chemosphere 78:4, pages 474-481.
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Pat WrightZhuang MiaoBarclay Shilliday. (2009) Metabolite quantitation: detector technology and MIST implications. Bioanalysis 1:4, pages 831-845.
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Robert Espina, Linning Yu, Jianyao Wang, Zeen Tong, Sarvesh Vashishtha, Rasmy Talaat, JoAnn Scatina & Abdul Mutlib. (2008) Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing. Chemical Research in Toxicology 22:2, pages 299-310.
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Serge Rezzi, Francia Arce Vera, François-Pierre J. Martin, Serena Wang, Dennis Lawler & Sunil Kochhar. (2008) Automated SPE-RP-HPLC fractionation of biofluids combined to off-line NMR spectroscopy for biomarker identification in metabonomics. Journal of Chromatography B 871:2, pages 271-278.
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Yuan Chen, Mario Monshouwer & William L. Fitch. (2006) Analytical Tools and Approaches for Metabolite Identification in Early Drug Discovery. Pharmaceutical Research 24:2, pages 248-257.
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Richard N. Trethewey & Arno J. Krotzky. 2007. The Handbook of Metabonomics and Metabolomics. The Handbook of Metabonomics and Metabolomics 443 487 .
. (2005) Current literature in mass spectrometry. Journal of Mass Spectrometry 40:8, pages 1110-1121.
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