Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 3
630
Views
50
CrossRef citations to date
0
Altmetric
Research Article

Comparative pharmacokinetics and metabolism of levetiracetam, a new anti-epileptic agent, in mouse, rat, rabbit and dog

, , , , &
Pages 281-300 | Received 16 Oct 2003, Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Eleni Karatza, Sophia L. Markantonis, Andria Savvidou, Anastasia Verentzioti, Anna Siatouni, Athanasia Alexoudi, Stylianos Gatzonis, Evgenia Mavrokefalou & Vangelis Karalis. (2020) Pharmacokinetic and pharmacodynamic modeling of levetiracetam: investigation of factors affecting the clinical outcome. Xenobiotica 50:9, pages 1090-1100.
Read now
Wenxia Luo, Sing Teang Kong, Shili Yang, Bernice Choi Wai Chan & Paul C Ho. (2013) A Simple Assay for Determination of Levetiracetam in Rat Dried Blood Spots by LC–MS/MS. Bioanalysis 5:15, pages 1843-1851.
Read now
Amy Z Crepeau & David M Treiman. (2010) Levetiracetam: a comprehensive review. Expert Review of Neurotherapeutics 10:2, pages 159-171.
Read now
G. A. Allan, J. I. Gedge, A. N. R. Nedderman, S. J. Roffey, H. F. Small & R. Webster. (2006) Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: A rationale for long-lived plasma radioactivity. Xenobiotica 36:5, pages 399-418.
Read now

Articles from other publishers (46)

Parsshava Mehta, Amira Soliman, Leyanis Rodriguez-Vera, Stephan Schmidt, Paula Muniz, Monica Rodriguez, Marta Forcadell, Emili Gonzalez-Perez & Valvanera Vozmediano. (2024) Interspecies Brain PBPK Modeling Platform to Predict Passive Transport through the Blood–Brain Barrier and Assess Target Site Disposition. Pharmaceutics 16:2, pages 226.
Crossref
Alicia Mastrocco, Jennifer Prittie, Chad West & Melissa Clark. (2023) A review of the pharmacology and clinical applications of levetiracetam in dogs and cats. Journal of Veterinary Emergency and Critical Care 34:1, pages 9-22.
Crossref
Danah ALRabeeah, Aliyah Almomen, Nourah Alzoman & Maria Arafah. (2023) Evaluating the bioequivalence of levetiracetam brand and generic oral tablets available in the Saudi market in vivo. Saudi Pharmaceutical Journal 31:10, pages 101758.
Crossref
Lisa D. Coles, Patricia G. Saletti, Christos Panagiotis Lisgaras, Pablo M. Casillas-Espinosa, Wei Liu, Qianyun Li, Nigel C. Jones, Sandy Shultz, Idrish Ali, Rhys Brady, Glenn Yamakawa, Matt Hudson, Juliana Silva, Emma Braine, Usha Mishra, James C. Cloyd, Terence J. O’Brien, Solomon L. Moshé & Aristea S. Galanopoulou. (2023) Levetiracetam Pharmacokinetics and Brain Uptake in a Lateral Fluid Percussion Injury Rat Model. Journal of Pharmacology and Experimental Therapeutics 386:2, pages 259-265.
Crossref
Peter Fisher & Jennifer E. Graham. 2023. Carpenter's Exotic Animal Formulary. Carpenter's Exotic Animal Formulary 574 625 .
Ewa Zwierzyńska & Bogusława Pietrzak. (2022) The differential effect of levetiracetam on memory and anxiety in rats. Epilepsy & Behavior 136, pages 108917.
Crossref
Fatma Ilgaz, Selin Seda Timur, Cemil Can Eylem, Emirhan Nemutlu, Çiğdem Eroğlu Erdem, Hakan Eroğlu & Hülya Gökmen-Özel. (2022) Do Thickening Agents Used in Dysphagia Diet Affect Drug Bioavailability?. European Journal of Pharmaceutical Sciences 174, pages 106197.
Crossref
Nadia O. Bamfo, Chelsea Hosey-Cojocari, Leslie Z. Benet & Connie M. Remsberg. (2021) Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans. Pharmaceutical Research 38:7, pages 1139-1156.
Crossref
Tapan Kumar Giri, Bijaya Ghosh, Preeta Bose, Sumana Saha & Arijit Sarkar. (2019) Extraction of levetiracetam for therapeutic drug monitoring by transdermal reverse iontophoresis. European Journal of Pharmaceutical Sciences 128, pages 54-60.
Crossref
Giulia Cagnotti, Rosangela Odore, Giulia Gardini, Stefano Amedeo, Iride Bertone, Giulia Guerriero, Laura Lentini, Elena Dappiano & Antonio D’Angelo. (2018) Pharmacokinetics of rectal levetiracetam as add-on treatment in dogs affected by cluster seizures or status epilepticus. BMC Veterinary Research 14:1.
Crossref
César Emmanuel Santana-Gómez, María Guadalupe Valle-Dorado, Ana Esmeralda Domínguez-Valentín, Arely Hernández-Moreno, Sandra Orozco-Suárez & Luisa Rocha. (2018) Neuroprotective effects of levetiracetam, both alone and combined with propylparaben, in the long-term consequences induced by lithium-pilocarpine status epilepticus. Neurochemistry International 120, pages 224-232.
Crossref
K. D. MacDonald, K. A. Hart, J. L. Davis, L. J. Berghaus & S. Giguère. (2017) Pharmacokinetics of the anticonvulsant levetiracetam in neonatal foals. Equine Veterinary Journal 50:4, pages 532-536.
Crossref
Emmanuel Bourgogne, Benoit Culot, Sylvie Dell'Aiera, Hugues Chanteux, Armel Stockis & Jean-Marie Nicolas. (2018) Off-line solid phase extraction and liquid chromatography-tandem mass spectrometry method for the quantitation of brivaracetam acid metabolites: Method validation and application to in vitro metabolism assays. Journal of Chromatography B 1086, pages 138-145.
Crossref
Hongmei Song, Uilki Tufa, Jonathan Chow, Nila Sivanenthiran, Chloe Cheng, Stellar Lim, Chiping Wu, Jiachun Feng, James H. Eubanks & Liang Zhang. (2018) Effects of Antiepileptic Drugs on Spontaneous Recurrent Seizures in a Novel Model of Extended Hippocampal Kindling in Mice. Frontiers in Pharmacology 9.
Crossref
Olivia A. Petritz & Sue Chen. (2018) Therapeutic Contraindications in Exotic Pets. Veterinary Clinics of North America: Exotic Animal Practice 21:2, pages 327-340.
Crossref
José Luis Cortes-Altamirano, Samuel Reyes-Long, Adriana Olmos-Hernández, Herlinda Bonilla-Jaime, Paul Carrillo-Mora, Cindy Bandala & Alfonso Alfaro-Rodriguez. (2018) Antinociceptive and pronociceptive effect of levetiracetam in tonic pain model. Pharmacological Reports 70:2, pages 385-389.
Crossref
Peter Fisher & Jennifer Graham. 2018. Exotic Animal Formulary. Exotic Animal Formulary 494 531 .
Elise Esneault, Guillaume Peyon & Vincent Castagné. (2017) Efficacy of anticonvulsant substances in the 6 Hz seizure test: Comparison of two rodent species. Epilepsy Research 134, pages 9-15.
Crossref
Melissa L. Barker‐Haliski, Wolfgang Löscher, H. Steve White & Aristea S. Galanopoulou. (2017) Neuroinflammation in epileptogenesis: Insights and translational perspectives from new models of epilepsy. Epilepsia 58:S3, pages 39-47.
Crossref
Hueng-Chuen Fan, Herng-Shen Lee, Kai-Ping Chang, Yi-Yen Lee, Hsin-Chuan Lai, Pi-Lien Hung, Hsiu-Fen Lee & Ching-Shiang Chi. (2016) The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism. International Journal of Molecular Sciences 17:8, pages 1242.
Crossref
Jean‐Marie Nicolas, Jonas Hannestad, Daniel HoldenSophie Kervyn, Nabeel NabulsiDominique Tytgat, Yiyun HuangHugues Chanteux, Ludovicus Staelens, Alain Matagne, François‐Xavier Mathy, Joël Mercier, Armel Stockis, Richard E. CarsonHenrik Klitgaard. (2015) Brivaracetam, a selective high‐affinity synaptic vesicle protein 2A ( SV 2A) ligand with preclinical evidence of high brain permeability and fast onset of action . Epilepsia 57:2, pages 201-209.
Crossref
M.J. Beasley & D.M. Boothe. (2015) Disposition of Extended Release Levetiracetam in Normal Healthy Dogs After Single Oral Dosing. Journal of Veterinary Internal Medicine 29:5, pages 1348-1353.
Crossref
K.R. Muñana, J.A. Nettifee‐Osborne & M.G. Papich. (2015) Effect of Chronic Administration of Phenobarbital, or Bromide, on Pharmacokinetics of Levetiracetam in Dogs with Epilepsy. Journal of Veterinary Internal Medicine 29:2, pages 614-619.
Crossref
Sean Sanders. 2015. Seizures in Dogs and Cats. Seizures in Dogs and Cats 166 220 .
Rodney Schnellbacher, Hugues Beaufrère, Dr Med Vet, Robert D. Arnold, Thomas N. TullyJrJr, Joerg Mayer & Stephen J. Divers. (2014) Pharmacokinetics of Levetiracetam in Healthy Hispaniolan Amazon Parrots ( Amazona ventralis ) After Oral Administration of a Single Dose . Journal of Avian Medicine and Surgery 28:3, pages 193-200.
Crossref
R.K. Peters, T. Schubert, R. Clemmons & T. Vickroy. (2014) Levetiracetam Rectal Administration in Healthy Dogs. Journal of Veterinary Internal Medicine 28:2, pages 504-509.
Crossref
Eric W. Fish, Abigail E. Agoglia, Michael C. Krouse, R. Grant Muller, J. Elliott Robinson & C.J. Malanga. (2014) Levetiracetam results in increased and decreased alcohol drinking with different access procedures in C57BL/6J mice. Behavioural Pharmacology 25:1, pages 61-70.
Crossref
H. Ziółkowski, J.J. Jaroszewski, N. Ziółkowska & A. Jasiecka. (2012) Characteristics of selected second-generation antiepileptic drugs used in dogs. Polish Journal of Veterinary Sciences 15:3, pages 571-582.
Crossref
Michelle Brogan Carnes, Todd W. Axlund & Dawn M. Boothe. (2011) Pharmacokinetics of levetiracetam after oral and intravenous administration of a single dose to clinically normal cats. American Journal of Veterinary Research 72:9, pages 1247-1252.
Crossref
S.A. MOORE, K.R. MUÑANA, M.G. PAPICH & J.A. NETTIFEE‐OSBORNE. (2011) The pharmacokinetics of levetiracetam in healthy dogs concurrently receiving phenobarbital. Journal of Veterinary Pharmacology and Therapeutics 34:1, pages 31-34.
Crossref
Michael D. Lorenz, Joan R. Coates & Marc Kent. 2011. Handbook of Veterinary Neurology. Handbook of Veterinary Neurology 384 412 .
Emilio Russo, Rita Citraro, Francesca Scicchitano, Salvatore De Fazio, Eugenio D. Di Paola, Andrew Constanti & Giovambattista De Sarro. (2010) Comparison of the antiepileptogenic effects of an early long‐term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy. Epilepsia 51:8, pages 1560-1569.
Crossref
Geoffrey J. Markowitz, Shilpa D. Kadam, Dawn M. Boothe, Natasha D. Irving & Anne M. Comi. (2010) The pharmacokinetics of commonly used antiepileptic drugs in immature CD1 mice. NeuroReport 21:6, pages 452-456.
Crossref
E. E. PATTERSON, V. GOEL, J. C. CLOYD, T. D. O’BRIEN, J. E. FISHER, A. W. DUNN & I. E. LEPPIK. (2008) Intramuscular, intravenous and oral levetiracetam in dogs: safety and pharmacokinetics. Journal of Veterinary Pharmacology and Therapeutics 31:3, pages 253-258.
Crossref
Holger A. Volk, Lara A. Matiasek, Alejandro Luján Feliu-Pascual, Simon R. Platt & Kate E. Chandler. (2008) The efficacy and tolerability of levetiracetam in pharmacoresistant epileptic dogs. The Veterinary Journal 176:3, pages 310-319.
Crossref
Curtis W. Dewey, Kerry S. Bailey, Dawn M. Boothe, Britton L. Badgley & Crisanta Cruz‐Espindola. (2008) Pharmacokinetics of single‐dose intravenous levetiracetam administration in normal dogs. Journal of Veterinary Emergency and Critical Care 18:2, pages 153-157.
Crossref
Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:9, pages 2031-2122.
Crossref
Wolfgang Löscher. (2007) The Pharmacokinetics of Antiepileptic Drugs in Rats: Consequences for Maintaining Effective Drug Levels during Prolonged Drug Administration in Rat Models of Epilepsy. Epilepsia 48:7, pages 1245-1258.
Crossref
Lawrence J. Hirsch, Hiba Arif, Richard Buchsbaum, David Weintraub, Jeansun Lee, Jennifer T. Chang, Stanley R. ResorJrJr & Carl W. Bazil. (2007) Effect of Age and Comedication on Levetiracetam Pharmacokinetics and Tolerability. Epilepsia 48:7, pages 1351-1359.
Crossref
Tim De Smedt, Robrecht Raedt, Kristl Vonck & Paul Boon. (2007) Levetiracetam: The Profile of a Novel Anticonvulsant Drug—Part I: Preclinical Data. CNS Drug Reviews 13:1, pages 43-56.
Crossref
Philip N. Patsalos, Sandirup Ghattaura, Neville Ratnaraj & Josemir W. Sander. (2006) In Situ Metabolism of Levetiracetam in Blood of Patients with Epilepsy. Epilepsia 47:11, pages 1818-1821.
Crossref
Curtis W. Dewey. (2006) Anticonvulsant Therapy in Dogs and Cats. Veterinary Clinics of North America: Small Animal Practice 36:5, pages 1107-1127.
Crossref
Enver Altas, Mustafa Vecdi Ertekin, Ozan Kuduban, Cemal Gundogdu, Elif Demirci & Yavuz Sutbeyaz. (2006) Effects of Piracetam Supplementation on Cochlear Damage Occuring in Guinea Pigs Exposed to Irradiation. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 29:7, pages 1460-1465.
Crossref
Cai Ji‐qun, Kumatoshi Ishihara, Takashi Nagayama, Tadao Serikawa & Masashi Sasa. (2005) Long‐lasting Antiepileptic Effects of Levetiracetam against Epileptic Seizures in the Spontaneously Epileptic Rat (SER): Differentiation of Levetiracetam from Conventional Antiepileptic Drugs. Epilepsia 46:9, pages 1362-1370.
Crossref
Hai‐Dun Yan, Cai Ji‐qun, Kumatoshi Ishihara, Takashi Nagayama, Tadao Serikawa & Masashi Sasa. (2005) Separation of Antiepileptogenic and Antiseizure Effects of Levetiracetam in the Spontaneously Epileptic Rat (SER). Epilepsia 46:8, pages 1170-1177.
Crossref
Thomas N. Ferraro & Russell J. Buono. (2005) The relationship between the pharmacology of antiepileptic drugs and human gene variation: An overview. Epilepsy & Behavior 7:1, pages 18-36.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.