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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 3
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Research Article

Use of 19F-nuclear magnetic resonance and gas chromatography-electron capture detection in the quantitative analysis of fluorine-containing metabolites in urine of sevoflurane-anaesthetized patients

H. Orhan Toxicology Department, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey; Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, NL-1081 HV, Amsterdam, The NetherlandsCorrespondence[email protected]
,
J. N. M. Commandeur Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, NL-1081 HV, Amsterdam, The Netherlands
,
G. Sahin Toxicology Department, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
,
U. Aypar Anesthesiology Department, Faculty of Medicine, Hacettepe University, Ankara, Turkey
,
A. Sahin Anesthesiology Department, Faculty of Medicine, Hacettepe University, Ankara, Turkey
&
N. P. E. Vermeulen Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, NL-1081 HV, Amsterdam, The Netherlands
Pages 301-316 | Received 07 Jul 2003, Published online: 22 Sep 2008

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Reema Deol & P. David Josephy. (2017) Acetylation of aromatic cysteine conjugates by recombinant human N-acetyltransferase 8. Xenobiotica 47:3, pages 202-207.
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Hilmi Orhan, Altan Sahin, Gonul Sahin, Ulku Aypar & Nico P.E. Vermeulen. (2013) Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity. Biomarkers 18:1, pages 73-81.
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Articles from other publishers (14)

Abdul E. Mutlib. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 31 .
Nga M. Do, Mark A. Olivier, John J. Salisbury & Carrie B. Wager. (2011) Application of Quantitative 19 F and 1 H NMR for Reaction Monitoring and In Situ Yield Determinations for an Early Stage Pharmaceutical Candidate . Analytical Chemistry 83:22, pages 8766-8771.
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Mark Hayward, Maria D. Bacolod, Qing Ping Han, Manuel Cajina & Zack Zou. 2011. Mass Spectrometry in Drug Metabolism and Disposition. Mass Spectrometry in Drug Metabolism and Disposition 353 381 .
Kirsten A. M. Ampt, Ruud L. E. G. Aspers, Martin Jaeger, Pepijn E. T. J. Geutjes, Maarten Honing & Sybren S. Wijmenga. (2011) Application of fluorine NMR for structure identification of steroids. Magnetic Resonance in Chemistry 49:5, pages 221-230.
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Abdul Mutlib, Robert Espina, Karthick Vishwanathan, Kathlene Babalola, Zecheng Chen, Christoph Dehnhardt, Aranapakam Venkatesan, Tarek Mansour, Inder Chaudhary, Rasmy Talaat & JoAnn Scatina. (2011) Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery. Drug Metabolism and Disposition 39:1, pages 106-116.
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Lawrence B. Alemany, Thomas B. MalloyJr.Jr. & Megan M. Nunes. (2010) Simple organofluorine compounds giving field‐dependent 13 C and 19 F NMR spectra with complex patterns: higher order effects and cross‐correlated relaxation . Magnetic Resonance in Chemistry 48:11, pages 882-891.
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Angus N. R. Nedderman. (2009) Metabolites in safety testing: metabolite identification strategies in discovery and development. Biopharmaceutics & Drug Disposition 30:4, pages 153-162.
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Robert Espina, Linning Yu, Jianyao Wang, Zeen Tong, Sarvesh Vashishtha, Rasmy Talaat, JoAnn Scatina & Abdul Mutlib. (2008) Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing. Chemical Research in Toxicology 22:2, pages 299-310.
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Bernard Testa & Stefanie D. Krämer. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:11, pages 2171-2336.
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R. Martino, V. Gilard & M. Malet-Martino. 2008. NMR Spectroscopy in Pharmaceutical Analysis. NMR Spectroscopy in Pharmaceutical Analysis 369 406 .
Chandra Prakash, Christopher L. Shaffer & Angus Nedderman. (2007) Analytical strategies for identifying drug metabolites. Mass Spectrometry Reviews 26:3, pages 340-369.
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Yuan Chen, Mario Monshouwer & William L. Fitch. (2006) Analytical Tools and Approaches for Metabolite Identification in Early Drug Discovery. Pharmaceutical Research 24:2, pages 248-257.
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Hilmi Orhan. (2007) Analyses of representative biomarkers of exposure and effect by chromatographic, mass spectrometric, and nuclear magnetic resonance techniques: Method development and application in life sciences. Journal of Separation Science 30:2, pages 149-174.
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Robert Martino, Véronique Gilard, Franck Desmoulin & Myriam Malet-Martino. (2005) Fluorine-19 or phosphorus-31 NMR spectroscopy: A suitable analytical technique for quantitative in vitro metabolic studies of fluorinated or phosphorylated drugs. Journal of Pharmaceutical and Biomedical Analysis 38:5, pages 871-891.
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