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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 2
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Research Article

Metabolism and excretion of loratadine in male and female mice, rats and monkeys

R Ramanathan Drug Metabolism and Pharmacokinetics, Schering–Plough Research Institute, Kenilworth, NJ, USACorrespondence[email protected]
,
N Alvarez Drug Metabolism and Pharmacokinetics, Schering–Plough Research Institute, Kenilworth, NJ, USA
,
A.-D Su Drug Metabolism and Pharmacokinetics, Schering–Plough Research Institute, Kenilworth, NJ, USA
,
S Chowdhury Drug Metabolism and Pharmacokinetics, Schering–Plough Research Institute, Kenilworth, NJ, USA
,
K Alton Drug Metabolism and Pharmacokinetics, Schering–Plough Research Institute, Kenilworth, NJ, USA
,
K Stauber Drug Metabolism and Pharmacokinetics, Schering–Plough Research Institute, Kenilworth, NJ, USA
&
J Patrick Drug Metabolism and Pharmacokinetics, Schering–Plough Research Institute, Kenilworth, NJ, USA
 show all
Pages 155-189 | Received 08 Sep 2004, Published online: 22 Sep 2008

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Yu Zhang, Jiaming Zhang, Qiuchi Xu, Yimeng Wang, Wenying Wu, Weiping Wang, Xiaoting Li & Tianhong Zhang. (2021) Simultaneous Determination of Loratadine and Its Metabolite Desloratadine in Beagle Plasma by LC-MS/MS and Application for Pharmacokinetics Study of Loratadine Tablets and Omeprazole‑Induced Drug–Drug Interaction. Drug Design, Development and Therapy 15, pages 5109-5122.
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Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki & Hiroshi Suemizu. (2020) Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes. Xenobiotica 50:6, pages 733-740.
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Silvi A. Chacko, Van T. Ly, Lisa J. Christopher & Jinping Gan. (2020) Hepatocyte spheroids as a viable in vitro model for recapitulation of complex in vivo metabolism pathways of loratadine in humans. Xenobiotica 50:6, pages 621-629.
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Joanna Folwarczna, Natalia Konarek, Karolina Freier, Dawid Karbowniczek, Piotr Londzin & Aleksandra Janas. (2019) Effects of loratadine, a histamine H1 receptor antagonist, on the skeletal system of young male rats. Drug Design, Development and Therapy 13, pages 3357-3367.
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Yvonne Aratyn-Schaus & Ragu Ramanathan. (2016) Advances in High-Resolution MS and Hepatocyte Models Solve A Long-Standing Metabolism Challenge: The Loratadine Story. Bioanalysis 8:16, pages 1645-1662.
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Federica Vacondio, Claudia Silva, Marco Mor & Bernard Testa. (2010) Qualitative structure-metabolism relationships in the hydrolysis of carbamates. Drug Metabolism Reviews 42:4, pages 551-589.
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Dorra Dridi, Mossadok Ben‐Attia, Mamane Sani, Nassim Djebli, François Ludovic Sauvage & Naceur A. Boughattas. (2008) Circadian Time‐Effect of Orally Administered Loratadine on Plasma Pharmacokinetics in Mice. Chronobiology International 25:4, pages 533-547.
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R. Ramanathan, L. Reyderman, A.-D. Su, N. Alvarez, S. K. Chowdhury, K. B. Alton, M. A. Wirth, R. P. Clement, P. Statkevich & J. E. Patrick. (2007) Disposition of desloratadine in healthy volunteers. Xenobiotica 37:7, pages 770-787.
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R. Ramanathan, L. Reyderman, K. Kulmatycki, A.-D. Su, N. Alvarez, S. K. Chowdhury, K. B. Alton, M. A. Wirth, R. P. Clement, P. Statkevich & J. E. Patrick. (2007) Disposition of loratadine in healthy volunteers. Xenobiotica 37:7, pages 753-769.
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Articles from other publishers (18)

Ying Xie, Sophie Irwin, Andrea Chupina Estrada, Becca Nelson, Ashlen Bullock, Lindsey Fontenot, Hanping Feng, Mingjun Sun & Hon Wai Koon. (2024) Loratadine as an Anti-inflammatory Agent Against Clostridium difficile Toxin B . The Journal of Infectious Diseases.
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Shotaro Uehara, Hiroshi Suemizu & Hiroshi Yamazaki. 2022. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary 307 328 .
Van-Long TruongMira JunWoo-Sik Jeong. (2021) Phytochemical and Over-The-Counter Drug Interactions: Involvement of Phase I and II Drug-Metabolizing Enzymes and Phase III Transporters. Journal of Medicinal Food 24:8, pages 786-805.
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Yuxin Zhang, Yihua Lu, Lijuan Wang, Yuan Tian & Zunjian Zhang. (2020) Pharmacokinetics and Tissue Distribution of Loratadine, Desloratadine and Their Active Metabolites in Rat based on a Newly Developed LC-MS/MS Analytical Method. Drug Research 70:11, pages 528-540.
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Elizabeth A. Stone, Kara J. Cutrona & Scott J. Miller. (2020) Asymmetric Catalysis upon Helically Chiral Loratadine Analogues Unveils Enantiomer-Dependent Antihistamine Activity. Journal of the American Chemical Society 142:29, pages 12690-12698.
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Yasmin Schmid, Alexander Navarini, Zita-Rose Manjaly Thomas, Bettina Pfleiderer, Stephan Krähenbühl & Simon M Mueller. (2019) Sex differences in the pharmacology of itch therapies—a narrative review. Current Opinion in Pharmacology 46, pages 122-142.
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M. Wang, J. Han, J. Domenico, Y. S. Shin, Y. Jia & E. W. Gelfand. (2016) Combined blockade of the histamine H1 and H4 receptor suppresses peanut-induced intestinal anaphylaxis by regulating dendritic cell function. Allergy 71:11, pages 1561-1574.
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Faraz Kazmi, Joanna E. Barbara, Phyllis Yerino & Andrew Parkinson. (2015) A Long-Standing Mystery Solved: The Formation of 3-Hydroxydesloratadine Is Catalyzed by CYP2C8 But Prior Glucuronidation of Desloratadine by UDP-Glucuronosyltransferase 2B10 Is an Obligatory Requirement. Drug Metabolism and Disposition 43:4, pages 523-533.
Crossref
Ruina Gao. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 5 .
Natasha Penner. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Venkata Suresh Ponnuru, B.R. Challa & Ramarao Nadendla. (2012) Quantification of desloratadine in human plasma by LC-ESI-MS/MS and application to a pharmacokinetic study. Journal of Pharmaceutical Analysis 2:3, pages 180-187.
Crossref
Michael T. Furlong, Chad E. Wujcik, Chengjie Ji & Yi Su. (2010) Identifying and overcoming bioanalytical challenges associated with chlorine-containing dehydrogenation metabolites. Rapid Communications in Mass Spectrometry 24:21, pages 3092-3102.
Crossref
Masahiro Miura, Wataru Hori, Yasushi Kasahara & Ippei Nakagawa. (2010) Quantitative assessment of the metabolic activation of alicyclic amines via aldehyde. Journal of Pharmacological and Toxicological Methods 61:1, pages 44-51.
Crossref
Ragu Ramanathan, S Çömezoglu & W Humphreys. 2009. Using Mass Spectrometry for Drug Metabolism Studies, Second Edition. Using Mass Spectrometry for Drug Metabolism Studies, Second Edition 127 203 .
Nicolas Picard, Dorra Dridi, François‐Ludovic Sauvage, Naceur A. Boughattas & Pierre Marquet. (2009) General unknown screening procedure for the characterization of human drug metabolites: Application to loratadine phase I metabolism. Journal of Separation Science 32:13, pages 2209-2217.
Crossref
Ragu Ramanathan, Ruyun Zhong, Neil Blumenkrantz, Swapan K. Chowdhury & Kevin B. Alton. (2007) Response normalized liquid chromatography nanospray ionization mass spectrometry. Journal of the American Society for Mass Spectrometry 18:10, pages 1891-1899.
Crossref
Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:3, pages 257-405.
Crossref
Ragulan Ramanathan, Swapan K. Chowdhury & Kevin B. Alton. 2005. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS 225 276 .

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