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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 3
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Research Article

Cyclophosphamide induces mRNA, protein and enzyme activity of cytochrome P450 in rat

H Xie Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
,
P Afsharian Department of Medicine, Division of Hematology, Laboratory of Hematology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
,
Y Terelius AstraZeneca R & D Södertälje, Department of Research DMPK, Södertälje, Sweden
,
R. A Mirghani Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
,
Ü Yasar Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
,
A-L Hagbjörk AstraZeneca R & D Södertälje, Department of Research DMPK, Södertälje, Sweden
,
S Lundgren Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
,
Y Hu AstraZeneca R & D Södertälje, Department of Research DMPK, Södertälje, Sweden
,
A Rane Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
&
M Hassan Department of Medicine, Division of Hematology, Laboratory of Hematology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, SwedenCorrespondence[email protected]
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Pages 239-251 | Received 10 Nov 2004, Published online: 22 Sep 2008

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Er-Jia Wang, George Mandakas, Jairam Palamanda, Xinjie Lin, Pramila Kumari, Inhou Chu, Anthony Soares, Roger J. Smith, Ronald D. Snyder & Yi-Zhong Gu. (2008) Temporal Evaluation of CYP mRNA in Mice Administered with Prototypical P450 Inducers: Comparison with Conventional Protein/Enzyme Methods. Drug and Chemical Toxicology 31:4, pages 501-513.
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G. Sun, R. D. Grindstaff, S.-F. Thai, G. R. Lambert, D. B. Tully, D. J. Dix & S. Nesnow. (2007) Induction of cytochrome P450 enzymes in rat liver by two conazoles, myclobutanil and triadimefon. Xenobiotica 37:2, pages 180-193.
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Jing Zhang, Quan Tian, Sui Yung Chan, Shu Chuen Li, Shufeng Zhou, Wei Duan & Yi-Zhun Zhu. (2005) Metabolism and Transport of Oxazaphosphorines and the Clinical Implications. Drug Metabolism Reviews 37:4, pages 611-703.
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Articles from other publishers (9)

Tarek Mohamed Kamal Motawi, Mira Magdy William, Mohammed Mostafa Nooh & Hanan Muhammad Abd-Elgawad. (2022) Amelioration of cyclophosphamide toxicity via modulation of metabolizing enzymes by avocado ( Persea americana) extract . Journal of Pharmacy and Pharmacology 74:3, pages 367-376.
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Aladaileh, Abukhalil, Saghir, Hanieh, Alfwuaires, Almaiman, Bin-Jumah & Mahmoud. (2019) Galangin Activates Nrf2 Signaling and Attenuates Oxidative Damage, Inflammation, and Apoptosis in a Rat Model of Cyclophosphamide-Induced Hepatotoxicity. Biomolecules 9:8, pages 346.
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I El-Serafi, M Fares, M Abedi-Valugerdi, P Afsharian, A Moshfegh, Y Terelius, Z Potácová & M Hassan. (2015) Cytochrome P450 2J2, a new key enzyme in cyclophosphamide bioactivation and a potential biomarker for hematological malignancies. The Pharmacogenomics Journal 15:5, pages 405-413.
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Zhen Zhang, Beikang Ge, Limin Zhou, Tai-Ning Lam & Zhong Zuo. (2014) Induction of liver cytochrome P450s by Danshen–Gegen formula is the leading cause for its pharmacokinetic interactions with warfarin. Journal of Ethnopharmacology 154:3, pages 672-686.
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Duan Wang, Linhao Li, Jennifer Fuhrman, Stephen Ferguson & Hongbing Wang. (2011) The Role of Constitutive Androstane Receptor in Oxazaphosphorine-Mediated Induction of Drug-Metabolizing Enzymes in Human Hepatocytes. Pharmaceutical Research 28:8, pages 2034-2044.
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Hiromi Suzuki, Tomoaki Inoue, Tomochika Matsushita, Kazuko Kobayashi, Ikuo Horii, Yoko Hirabayashi & Tohru Inoue. (2008) In vitro gene expression analysis of hepatotoxic drugs in rat primary hepatocytes . Journal of Applied Toxicology 28:2, pages 227-236.
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Parvaneh Afsharian, Ylva Terelius, Zuzana Hassan, Christina Nilsson, Stefan Lundgren & Moustapha Hassan. (2007) The Effect of Repeated Administration of Cyclophosphamide on Cytochrome P450 2B in Rats. Clinical Cancer Research 13:14, pages 4218-4224.
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Amadeo M. Parissenti, Stacey L. Hembruff, David J. Villeneuve, Zachary Veitch, Baoqing Guo & Jamei Eng. (2007) Gene expression profiles as biomarkers for the prediction of chemotherapy drug response in human tumour cells. Anti-Cancer Drugs 18:5, pages 499-523.
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Guobin Sun, Sheau-Fung Thai, Guy R. Lambert, Douglas C. Wolf, Douglas B. Tully, Amber K. Goetz, Michael H. George, Rachel D. Grindstaff, David J. Dix & Stephen Nesnow. (2006) Fluconazole-induced hepatic cytochrome P450 gene expression and enzymatic activities in rats and mice. Toxicology Letters 164:1, pages 44-53.
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