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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 3
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Research Article

Absorption, distribution, metabolism and excretion of an inhalation dose of [14C] 4,4'-methylenediphenyl diisocyanate in the male rat

A Gledhill Central Toxicology Laboratory, Alderley Park, UKCorrespondence[email protected]
,
A Wake Central Toxicology Laboratory, Alderley Park, UK
,
P Hext Central Toxicology Laboratory, Alderley Park, UK
,
E Leibold BASF AG Product Safety, Ludwigshafen, Germany
&
R Shiotsuka Bayer CropScience, Stilwell, KS, USA
Pages 273-292 | Received 28 Jun 2004, Published online: 22 Sep 2008

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Sajjad Mozaffari, Majid Bayatian, Nan-Hung Hsieh, Monireh Khadem, Amir Abbasi Garmaroudi, Khosro Ashrafi & Seyed Jamaleddin Shahtaheri. (2023) Reconstruction of exposure to methylene diphenyl-4,4′-diisocyanate (MDI) aerosol using computational fluid dynamics, physiologically based toxicokinetics and statistical modeling. Inhalation Toxicology 35:11-12, pages 285-299.
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Adam V. Wisnewski, Jean Kanyo, Jennifer Asher, James A. Goodrich, Grace Barnett, Lyn Patrylak, Jian Liu, Carrie A. Redlich & Ala F. Nassar. (2018) Reaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy. Xenobiotica 48:5, pages 488-497.
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Adam V. Wisnewski, Jian Liu & Ala F. Nassar. (2016) In vitro cleavage of diisocyanate-glutathione conjugates by human gamma-glutamyl transpeptidase-1. Xenobiotica 46:8, pages 726-732.
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M. A. Hughes, M. Carson, M. A. Collins, A. T. Jolly, D. M. Molenaar, W. Steffens & G. M. H. Swaen. (2014) Does diisocyanate exposure result in neurotoxicity?. Clinical Toxicology 52:4, pages 242-257.
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AngelaR. Lemons, PaulD. Siegel, Morgen Mhike, BrandonF. Law, JustinM. Hettick, ToniA. Bledsoe, AjayP. Nayak, DonaldH. Beezhold & BrettJ. Green. (2014) A Murine Monoclonal Antibody with Broad Specificity for Occupationally Relevant Diisocyanates. Journal of Occupational and Environmental Hygiene 11:2, pages 101-110.
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Ronald N. Shiotsuka, Barry P. Stuart, Jeffrey M. Charles, Glenn S. Simon, Paul Malichky & Janet M. Mostowy. (2010) Chronic inhalation exposures of Fischer 344 rats to 1,6-hexamethylene diisocyanate did not reveal a carcinogenic potential. Inhalation Toxicology 22:10, pages 875-887.
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B. Scholten, J. Westerhout, A. Pronk, R. Stierum, J. Vlaanderen, R. Vermeulen, K. Jones, T. Santonen & L. Portengen. (2023) A physiologically-based kinetic (PBK) model for work-related diisocyanate exposure: Relevance for the design and reporting of biomonitoring studies. Environment International 174, pages 107917.
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Thomas Schupp & Patrick M Plehiers. (2022) Absorption, distribution, metabolism, and excretion of methylene diphenyl diisocyanate and toluene diisocyanate: Many similarities and few differences. Toxicology and Industrial Health 38:9, pages 500-528.
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Michael Bartels, William van Osdol, Maxime Le Merdy, Anne Chappelle, Adam Kuhl & Robert West. (2022) In silico predictions of absorption of MDI substances after dermal or inhalation exposures to support a category based read-across assessment. Regulatory Toxicology and Pharmacology 129, pages 105117.
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Adam V. Wisnewski, Jian Liu & Carrie A. Redlich. (2020) Analysis of Lung Gene Expression Reveals a Role for Cl − Channels in Diisocyanate-induced Airway Eosinophilia in a Mouse Model of Asthma Pathology . American Journal of Respiratory Cell and Molecular Biology 63:1, pages 25-35.
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Maggy Lépine, Lekha Sleno, Jacques Lesage & Sébastien Gagné. (2019) A validated UPLC-MS/MS method for the determination of aliphatic and aromatic isocyanate exposure in human urine. Analytical and Bioanalytical Chemistry 412:3, pages 753-762.
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Maggy Lépine, Lekha Sleno, Jacques Lesage & Sébastien Gagné. (2019) A validated liquid chromatography/tandem mass spectrometry method for 4,4′-methylenedianiline quantitation in human urine as a measure of 4,4′-methylene diphenyl diisocyanate exposure. Rapid Communications in Mass Spectrometry 33:6, pages 600-606.
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Gabriele Leng & Wolfgang Gries. (2017) New specific and sensitive biomonitoring methods for chemicals of emerging health relevance. International Journal of Hygiene and Environmental Health 220:2, pages 113-122.
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A.V. Wisnewski, J. Liu & A.F. Nassar. (2016) Identification of novel reaction products of methylene-bis - phenylisocyanate (“MDI”) with oxidized glutathione in aqueous solution and also during incubation of MDI with a murine hepatic S9 fraction. Toxicology in Vitro 36, pages 97-104.
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. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 52 .
Leah G. Luna, Brett J. Green, Fagen Zhang, Scott M. Arnold, Paul D. Siegel & Michael J. Bartels. (2014) Quantitation of 4,4′-methylene diphenyl diisocyanate human serum albumin adducts. Toxicology Reports 1, pages 743-751.
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R.J. Parod. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology 1 5 .
Angela R. Lemons, Toni A. Bledsoe, Paul D. Siegel, Donald H. Beezhold & Brett J. Green. (2013) Development of sandwich ELISAs for the detection of aromatic diisocyanate adducts. Journal of Immunological Methods 397:1-2, pages 66-70.
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Wolfgang Gries & Gabriele Leng. (2013) Analytical determination of specific 4,4′-methylene diphenyl diisocyanate hemoglobin adducts in human blood. Analytical and Bioanalytical Chemistry 405:23, pages 7205-7213.
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Volker Krone. 2013. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays 799 834 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 45 .
Jürgen Pauluhn. (2011) Interrelating the acute and chronic mode of action of inhaled methylenediphenyl diisocyanate (MDI) in rats assisted by computational toxicology. Regulatory Toxicology and Pharmacology 61:3, pages 351-364.
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John J. Clary. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Margareta Littorin, Saimei Hou, Karin Broberg, Jonas Björk, Susanne Fält, Galbani Abdoulaye, Malgorzata Kalemba, Charlotta Ryk & Staffan Skerfving. (2007) Influence of polymorphic metabolic enzymes on biotransformation and effects of diphenylmethane diisocyanate. International Archives of Occupational and Environmental Health 81:4, pages 429-441.
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Jürgen Pauluhn, William E. Brown, Paul Hext, Edgar Leibold & Gabriele Leng. (2006) Analysis of biomarkers in rats and dogs exposed to polymeric methylenediphenyl diisocyanate (pMDI) and its glutathione adduct. Toxicology 222:3, pages 202-212.
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Xiaoyan Zhang, Jason C. Lambert, Mark A. Doll, Jason M. Walraven, Gavin E. Arteel & David W. Hein. (2006) 4,4′-Methylenedianiline-Induced Hepatotoxicity Is Modified by N -Acetyltransferase 2 (NAT2) Acetylator Polymorphism in the Rat . Journal of Pharmacology and Experimental Therapeutics 316:1, pages 289-294.
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