Identification of metabolites of [¹⁴C]zonampanel, an α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist, following intravenous infusion in healthy volunteers

T. Minematsu Drug Metabolism Laboratories, Yamanouchi Pharmaceutical, Co. Ltd, Tokyo, JapanCorrespondence[email protected]

K.-Y. Sohda Drug Metabolism Laboratories, Yamanouchi Pharmaceutical, Co. Ltd, Tokyo, Japan

T. Hashimoto Drug Metabolism Laboratories, Yamanouchi Pharmaceutical, Co. Ltd, Tokyo, Japan

H. Imai Drug Metabolism Laboratories, Yamanouchi Pharmaceutical, Co. Ltd, Tokyo, Japan

T. Usui Drug Metabolism Laboratories, Yamanouchi Pharmaceutical, Co. Ltd, Tokyo, Japan

H. Kamimura Drug Metabolism Laboratories, Yamanouchi Pharmaceutical, Co. Ltd, Tokyo, Japan

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T. Minematsu, T. Hashimoto, T. Usui & H. Kamimura. (2008) Characterization of renal tubular apical efflux of zonampanel, an α-amino-3-hydroxy-5- methylisoxazole-4-propionate receptor antagonist, in humans. Xenobiotica 38:9, pages 1191-1202.
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Eric Leininger & Andrei B. Belousov. (2009) Recovery of network-driven glutamatergic activity in rat hippocampal neurons during chronic glutamate receptor blockade. Brain Research 1251, pages 87-102.
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Tsuyoshi Minematsu, Tadashi Hashimoto, Toshiko Aoki, Takashi Usui & Hidetaka Kamimura. (2008) Role of Organic Anion Transporters in the Pharmacokinetics of Zonampanel, an α-Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Antagonist, in Rats. Drug Metabolism and Disposition 36:8, pages 1496-1504.
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Satoshi Ohmori, Masahiro Miura, Chifuyu Toriumi, Yoshiaki Satoh & Tsuyoshi Ooie. (2007) Absorption, Metabolism, and Excretion of [ 14 C]Imidafenacin, a New Compound for Treatment of Overactive Bladder, After Oral Administration to Healthy Male Subjects . Drug Metabolism and Disposition 35:9, pages 1624-1633.
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Identification of metabolites of [¹⁴C]zonampanel, an α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist, following intravenous infusion in healthy volunteers

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Identification of metabolites of [14C]zonampanel, an α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist, following intravenous infusion in healthy volunteers

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Identification of metabolites of [¹⁴C]zonampanel, an α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist, following intravenous infusion in healthy volunteers