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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 4
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Research Article

Pharmacokinetics and metabolism of TR-14035, a novel antagonist of α4β1/α4β7 integrin mediated cell adhesion, in rat and dog

M. Tsuda-Tsukimoto Exploratory DMPK, Exploratory Toxicology & DMPK Research Laboratories, Tanabe Seiyaku Co., Ltd, 2-2-50, Kawagishi, Toda, Saitama 335-8505, JapanCorrespondence[email protected]
,
Y. Ogasawara Exploratory DMPK, Exploratory Toxicology & DMPK Research Laboratories, Tanabe Seiyaku Co., Ltd, 2-2-50, Kawagishi, Toda, Saitama 335-8505, Japan
&
T. Kume Exploratory DMPK, Exploratory Toxicology & DMPK Research Laboratories, Tanabe Seiyaku Co., Ltd, 2-2-50, Kawagishi, Toda, Saitama 335-8505, Japan
Pages 373-389 | Received 10 Dec 2004, Published online: 22 Sep 2008

Citations (5)

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Jefferson W Tilley. (2008) Very late antigen-4 integrin antagonists. Expert Opinion on Therapeutic Patents 18:8, pages 841-859.
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Articles from other publishers (4)

Shayne Cox GadAlexander V. Lyubimov & Ihor Bekersky. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Fumihito Muro, Shin Iimura, Yuuichi Sugimoto, Yoshiyuki Yoneda, Jun Chiba, Toshiyuki Watanabe, Masaki Setoguchi, Yutaka Iigou, Keiko Matsumoto, Atsushi Satoh, Gensuke Takayama, Tomoe Taira, Mika Yokoyama, Tohru Takashi, Atsushi Nakayama & Nobuo Machinaga. (2009) Discovery of trans -4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4 S )-methoxy-(2 S )-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid: An Orally Active, Selective Very Late Antigen-4 Antagonist . Journal of Medicinal Chemistry 52:24, pages 7974-7992.
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Minoru Tsuda-Tsukimoto, Tomoji Maeda, Takashi Iwanaga, Toshiyuki Kume & Ikumi Tamai. (2006) Characterization of Hepatobiliary Transport Systems of a Novel α4β1/α4β7 Dual Antagonist, TR-14035. Pharmaceutical Research 23:11, pages 2646-2656.
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Minoru Tsuda-Tsukimoto, Yuko Ogasawara & Toshiyuki Kume. (2005) Role of Human Liver Cytochrome P450 2C9 in the Metabolism of a Novel α4β1/α4β7 Dual Antagonist, TR-14035. Drug Metabolism and Pharmacokinetics 20:2, pages 127-134.
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