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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 5
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Research Article

Impact of end-product inhibition on the determination of in vitro metabolic clearance

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Pages 439-454 | Received 19 Jan 2005, Published online: 16 Oct 2008

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Nicola J. Hewitt, María José Gómez Lechón, J. Brian Houston, David Hallifax, Hayley S. Brown, Patrick Maurel, J. Gerald Kenna, Lena Gustavsson, Christina Lohmann, Christian Skonberg, Andre Guillouzo, Gregor Tuschl, Albert P. Li, Edward LeCluyse, Geny M. M. Groothuis & Jan G. Hengstler. (2007) Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies. Drug Metabolism Reviews 39:1, pages 159-234.
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Xinning Yang, Jianghong Fan & Lei Zhang. 2021. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 595 629 .
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Jianghong Fan & Inés A.M. de Lannoy. (2014) Pharmacokinetics. Biochemical Pharmacology 87:1, pages 93-120.
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Erik Sjögren, Hans Lennernäs, Tommy B. Andersson, Johan Gråsjö & Ulf Bredberg. (2009) The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CL int ), Maximum Velocity of the Metabolic Reaction ( V max ), and Michaelis Constant ( K m ): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations . Drug Metabolism and Disposition 37:1, pages 47-58.
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Alison J. Parker & J. Brian Houston. (2008) Rate-Limiting Steps in Hepatic Drug Clearance: Comparison of Hepatocellular Uptake and Metabolism with Microsomal Metabolism of Saquinavir, Nelfinavir, and Ritonavir. Drug Metabolism and Disposition 36:7, pages 1375-1384.
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Balázs Leitgeb, András Szekeres, László Manczinger, Csaba Vágvölgyi & László Kredics. (2007) The History of Alamethicin: A Review of the Most Extensively Studied Peptaibol. Chemistry & Biodiversity 4:6, pages 1027-1051.
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David Hallifax & J. Brian Houston. (2006) Uptake and Intracellular Binding of Lipophilic Amine Drugs by Isolated Rat Hepatocytes and Implications for Prediction of in Vivo Metabolic Clearance. Drug Metabolism and Disposition 34:11, pages 1829-1836.
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