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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 6
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Research Article

Prediction of oral clearance from in vitro metabolic data using recombinant CYPs: Comparison among well-stirred, parallel-tube, distributed and dispersion models

T. Yamamoto Drug Metabolism Laboratory, Medicinal Development Research Laboratories, Taisho Pharmaceutical Co., Ltd, Saitama, JapanCorrespondence[email protected]
,
H. Itoga Drug Metabolism Laboratory, Medicinal Development Research Laboratories, Taisho Pharmaceutical Co., Ltd, Saitama, Japan
,
Y. Kohno Drug Metabolism Laboratory, Medicinal Development Research Laboratories, Taisho Pharmaceutical Co., Ltd, Saitama, Japan
,
K. Nagata Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan
&
Y. Yamazoe Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan
Pages 627-646 | Received 10 Dec 2004, Published online: 22 Sep 2008

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María José Gómez-Lechón, José V Castell & María Teresa Donato. (2008) An update on metabolism studies using human hepatocytes in primary culture. Expert Opinion on Drug Metabolism & Toxicology 4:7, pages 837-854.
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Sumit Bansal, Mayur K. Ladumor, Mary F. Paine & Jashvant D. Unadkat. (2023) A physiologically-based pharmacokinetic model for cannabidiol in healthy adults, hepatically-impaired adults, and children . Drug Metabolism and Disposition, pages DMD-AR-2022-001128.
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Hlengwa N., Masilela C.Mtambo T. R., Sithole S.Naidoo S., Machaba K. E.Shabalala S. C., Ntamo Y.Dludla P. V. & Milase R. N.. (2023) In Vitro Hepatic Models to Assess Herb–Drug Interactions: Approaches and Challenges. Pharmaceuticals 16:3, pages 409.
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Priyanka R. Kulkarni, Amir S. Youssef & Aneesh A. Argikar. 2021. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 369 417 .
David J. Wilkinson, Rosalind L. Southall, Mingguang Li, Lisa M. Wright, Lindsay J. Corfield, Thomas A. Heeley, Benjamin Bratby, Ranbir Mannu, Sarah L. Johnson, Victoria Shaw, Holly L. Friett, Louise A. Blakeburn, John S. Kendrick & Michael B. Otteneder. (2017) Minipig and Human Metabolism of Aldehyde Oxidase Substrates: In Vitro–In Vivo Comparisons. The AAPS Journal 19:4, pages 1163-1174.
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Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 377 385 .
Jan H. Beumer, Venkateswaran C. Pillai, Robert A. Parise, Susan M. Christner, Brian F. Kiesel, Michelle A. Rudek & Raman Venkataramanan. (2015) Human hepatocyte assessment of imatinib drug-drug interactions - complexities in clinical translation. British Journal of Clinical Pharmacology 80:5, pages 1097-1108.
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Venkateswaran C. Pillai, Robert A. Parise, Susan M. Christner, Michelle A. Rudek, Jan H. Beumer & Raman Venkataramanan. (2014) Potential interactions between HIV drugs, ritonavir and efavirenz and anticancer drug, nilotinib-a study in primary cultures of human hepatocytes that is applicable to HIV patients with cancer. The Journal of Clinical Pharmacology 54:11, pages 1272-1279.
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Venkateswaran C. Pillai, Raman Venkataramanan, Robert A. Parise, Susan M. Christner, Roberto Gramignoli, Stephen C. Strom, Michelle A. Rudek & Jan H. Beumer. (2013) Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer. Drug Metabolism and Disposition 41:10, pages 1843-1851.
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Michael Stocks. 2013. Introduction to Biological and Small Molecule Drug Research and Development. Introduction to Biological and Small Molecule Drug Research and Development 81 126 .
W. Griffith Humphreys. 2011. Mass Spectrometry in Drug Metabolism and Disposition. Mass Spectrometry in Drug Metabolism and Disposition 229 253 .
Takehito Yamamoto, Hiroshi Suzuki & Akihiro Hisaka. 2011. Mass Spectrometry in Drug Metabolism and Disposition. Mass Spectrometry in Drug Metabolism and Disposition 197 228 .
Masato Chiba, Yasuyuki Ishii & Yuichi Sugiyama. (2009) Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development. The AAPS Journal 11:2.
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Paulo Paixão, Luís F. Gouveia & José A.G. Morais. (2009) Prediction of drug distribution within blood. European Journal of Pharmaceutical Sciences 36:4-5, pages 544-554.
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María José Gómez-Lechón, José Vicente Castell & María Teresa Donato. (2007) Hepatocytes—the choice to investigate drug metabolism and toxicity in man: In vitro variability as a reflection of in vivo. Chemico-Biological Interactions 168:1, pages 30-50.
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Nuggehally R. Srinivas. (2006) Drug disposition of chiral and achiral drug substrates metabolized by cytochrome P450 2D6 isozyme: case studies, analytical perspectives and developmental implications. Biomedical Chromatography 20:6-7, pages 466-491.
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