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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 7
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Research Article

Impaired glutathione-conjugating capacity by cryopreserved human and rat hepatocytes

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Pages 727-736 | Received 01 Mar 2005, Published online: 22 Sep 2008

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Read on this site (4)

Jian Jiang, Jarno EJ Wolters, Simone G van Breda, Jos C Kleinjans & Theo M de Kok. (2015) Development of novel tools for the in vitro investigation of drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 11:10, pages 1523-1537.
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Sanja Juric, Patrik Lundquist, Yin Hu, Anna Juréus & Anna-Karin Sohlenius-Sternbeck. (2013) The utility of cold-preserved human hepatocytes in studies on cytochrome P450 induction and hepatic drug transport. Xenobiotica 43:9, pages 785-791.
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Anna-Pia Palmgren, Britt-Marie Fihn, James Bird, Paul Courtney & Ken Grime. (2013) A novel matrix for the short-term storage of cells: utility in drug metabolism and drug transporter studies with rat, dog and human hepatocytes. Xenobiotica 43:6, pages 487-497.
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E. Floby, J. Johansson, J. Hoogstraate, N. J. Hewitt, J. Hill & A.-K. Sohlenius-Sternbeck. (2009) Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes. Xenobiotica 39:9, pages 656-662.
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Articles from other publishers (15)

Jieyu Xu, Shingo Oda & Tsuyoshi Yokoi. (2018) Cell-based assay using glutathione-depleted HepaRG and HepG2 human liver cells for predicting drug-induced liver injury. Toxicology in Vitro 48, pages 286-301.
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Zhican Wang, Ying Fang, Juli Teague, Hansen Wong, Christophe Morisseau, Bruce D. Hammock, Dan A. Rock & Zhengping Wang. (2017) In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s. Drug Metabolism and Disposition 45:7, pages 712-720.
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Sonia Sentellas, Oriol Morales-Ibanez, Miriam Zanuy & Joan J. Albertí. (2014) GSSG/GSH ratios in cryopreserved rat and human hepatocytes as a biomarker for drug induced oxidative stress. Toxicology in Vitro 28:5, pages 1006-1015.
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Patrik Lundquist, Johan Lööf, Anna-Karin Sohlenius-Sternbeck, Eva Floby, Jenny Johansson, Johan Bylund, Janet Hoogstraate, Lovisa Afzelius & Tommy B. Andersson. (2014) The Impact of Solute Carrier (SLC) Drug Uptake Transporter Loss in Human and Rat Cryopreserved Hepatocytes on Clearance Predictions. Drug Metabolism and Disposition 42:3, pages 469-480.
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Patricio Godoy, Nicola J. Hewitt, Ute Albrecht, Melvin E. Andersen, Nariman Ansari, Sudin Bhattacharya, Johannes Georg Bode, Jennifer Bolleyn, Christoph Borner, Jan Böttger, Albert Braeuning, Robert A. Budinsky, Britta Burkhardt, Neil R. Cameron, Giovanni Camussi, Chong-Su Cho, Yun-Jaie Choi, J. Craig Rowlands, Uta Dahmen, Georg Damm, Olaf Dirsch, María Teresa Donato, Jian Dong, Steven Dooley, Dirk Drasdo, Rowena Eakins, Karine Sá Ferreira, Valentina Fonsato, Joanna Fraczek, Rolf Gebhardt, Andrew Gibson, Matthias Glanemann, Chris E. P. Goldring, María José Gómez-Lechón, Geny M. M. Groothuis, Lena Gustavsson, Christelle Guyot, David Hallifax, Seddik Hammad, Adam Hayward, Dieter Häussinger, Claus Hellerbrand, Philip Hewitt, Stefan Hoehme, Hermann-Georg Holzhütter, J. Brian Houston, Jens Hrach, Kiyomi Ito, Hartmut Jaeschke, Verena Keitel, Jens M. Kelm, B. Kevin Park, Claus Kordes, Gerd A. Kullak-Ublick, Edward L. LeCluyse, Peng Lu, Jennifer Luebke-Wheeler, Anna Lutz, Daniel J. Maltman, Madlen Matz-Soja, Patrick McMullen, Irmgard Merfort, Simon Messner, Christoph Meyer, Jessica Mwinyi, Dean J. Naisbitt, Andreas K. Nussler, Peter Olinga, Francesco Pampaloni, Jingbo Pi, Linda Pluta, Stefan A. Przyborski, Anup Ramachandran, Vera Rogiers, Cliff Rowe, Celine Schelcher, Kathrin Schmich, Michael Schwarz, Bijay Singh, Ernst H. K. Stelzer, Bruno Stieger, Regina Stöber, Yuichi Sugiyama, Ciro Tetta, Wolfgang E. Thasler, Tamara Vanhaecke, Mathieu Vinken, Thomas S. Weiss, Agata Widera, Courtney G. Woods, Jinghai James Xu, Kathy M. Yarborough & Jan G. Hengstler. (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Archives of Toxicology 87:8, pages 1315-1530.
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Line R. Olsen, Mark P. Grillo & Christian Skonberg. (2011) Constituents in Kava Extracts Potentially Involved in Hepatotoxicity: A Review. Chemical Research in Toxicology 24:7, pages 992-1002.
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Urban Fagerholm. (2007) Prediction of human pharmacokinetics—evaluation of methods for prediction of hepatic metabolic clearance. Journal of Pharmacy and Pharmacology 59:6, pages 803-828.
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Olavi PelkonenAri Tolonen, Timo Korjamo, Miia Turpeinen & Hannu Raunio. (2009) From known knowns to known unknowns: predicting in vivo drug metabolites . Bioanalysis 1:2, pages 393-414.
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J.A. Sinclair, C. Henderson, I. Martin, M.H. Grant & J.N.A. Tettey. (2009) The extent of phase I and phase II reactions is affected by the choice of enzyme used to prepare rat hepatocytes. Chemico-Biological Interactions 179:2-3, pages 256-262.
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Katie Chan, Neil Jensen & Peter J. O'Brien. (2008) Structure–activity relationships for thiol reactivity and rat or human hepatocyte toxicity induced by substituted p ‐benzoquinone compounds . Journal of Applied Toxicology 28:5, pages 608-620.
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Therese Söderdahl, Barbara Küppers-Munther, Nico Heins, Josefina Edsbagge, Petter Björquist, Ian Cotgreave & Bengt Jernström. (2007) Glutathione transferases in hepatocyte-like cells derived from human embryonic stem cells. Toxicology in Vitro 21:5, pages 929-937.
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John C. L. Erve, Sarvesh C. Vashishtha, William DeMaio & Rasmy E. Talaat. (2007) Metabolism of Prazosin in Rat, Dog, and Human Liver Microsomes and Cryopreserved Rat and Human Hepatocytes and Characterization of Metabolites by Liquid Chromatography/Tandem Mass Spectrometry. Drug Metabolism and Disposition 35:6, pages 908-916.
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Albert P. Li. (2007) Human hepatocytes: Isolation, cryopreservation and applications in drug development. Chemico-Biological Interactions 168:1, pages 16-29.
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David J. Stevenson, Caroline Morgan, Lesley I. McLellan & M. Helen Grant. (2007) Reduced glutathione levels and expression of the enzymes of glutathione synthesis in cryopreserved hepatocyte monolayer cultures. Toxicology in Vitro 21:3, pages 527-532.
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Jae H. Chang, Christopher J. Kochansky & Magang Shou. (2006) The Role of P-glycoprotein in the Bioactivation of Raloxifene. Drug Metabolism and Disposition 34:12, pages 2073-2078.
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