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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 8
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Research Article

Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein

Ü. Yasar Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
,
A. Annas Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
,
J.-O. Svensson Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
,
L. Lazorova Department of Pharmacy, Uppsala University, Uppsala, Sweden
,
P. Artursson Department of Pharmacy, Uppsala University, Uppsala, Sweden
&
A. Al-Shurbaji Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, Stockholm, SwedenCorrespondence[email protected]
Pages 785-796 | Received 31 Jan 2005, Published online: 22 Sep 2008

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Alan L. Myers, Jitesh D. Kawedia, Richard E. Champlin, Mark A. Kramer, Yago Nieto, Romi Ghose & Borje S. Andersson. (2017) Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review. Expert Opinion on Drug Metabolism & Toxicology 13:9, pages 901-923.
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Shu-Feng Zhou, Jun-Ping Liu & Balram Chowbay. (2009) Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metabolism Reviews 41:2, pages 89-295.
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Articles from other publishers (13)

Yasushi Yamazoe, Yoshiya Yamamura & Kouichi Yoshinari. (2022) Construction of a fused grid-based template system of CYP2C9 and its application. Drug Metabolism and Pharmacokinetics 45, pages 100451.
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Rachael Lawson, Christine E. Staatz, Christopher J. Fraser & Stefanie Hennig. (2020) Review of the Pharmacokinetics and Pharmacodynamics of Intravenous Busulfan in Paediatric Patients. Clinical Pharmacokinetics 60:1, pages 17-51.
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James C. Thigpen, Brian L. Odle & Sam Harirforoosh. (2019) Opioids: A Review of Pharmacokinetics and Pharmacodynamics in Neonates, Infants, and Children. European Journal of Drug Metabolism and Pharmacokinetics 44:5, pages 591-609.
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Nuggehally R. Srinivas. (2018) Reduced Ketobemidone Usage in Quadratus Lumborum Block Patients After Cesarean Delivery: Clinical Pharmacology Views. Anesthesia & Analgesia 127:1, pages 311-311.
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Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 173 201 .
Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 387 430 .
S. LUNDEBERG, N. STEPHANSON, C.-O. STILLER & S. EKSBORG. (2012) Pharmacokinetics after a single intravenous dose of the opioid ketobemidone in neonates. Acta Anaesthesiologica Scandinavica 56:8, pages 1026-1031.
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Andrew A. Somogyi & Janet K. Coller. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics 403 428 .
Shu-Feng Zhou, Zhi-Wei Zhou & Min Huang. (2010) Polymorphisms of human cytochrome P450 2C9 and the functional relevance. Toxicology 278:2, pages 165-188.
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S. LUNDEBERG, N. STEPHANSON, P. LAFOLIE, G. L. OLSSON, C.‐O. STILLER & S. EKSBORG. (2010) Pharmacokinetics after an intravenous single dose of the opioid ketobemidone in children. Acta Anaesthesiologica Scandinavica 54:4, pages 435-441.
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Shayne Cox GadEugene G. Hrycay & Stelvio M. Bandiera. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Ingela Sundström, Joris Arts, Douglas Westerlund & Per E. Andrén. (2010) In vivo investigation of brain and systemic ketobemidonemetabolism. The Analyst 135:2, pages 405-413.
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Janet K. Coller, Lona L. Christrup & Andrew A. Somogyi. (2008) Role of active metabolites in the use of opioids. European Journal of Clinical Pharmacology 65:2, pages 121-139.
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