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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 8
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Research Article

Effect of 1-aminobenzotriazole on the in vitro metabolism and single-dose pharmacokinetics of chlorzoxazone, a selective CYP2E1 substrate in Wistar rats

S. Muzeeb Drug Metabolism and Pharmacokinetics, Discovery Research, Dr. Reddy's Laboratories Ltd, Miyapur, Hyderabad, India
,
M. K. Pasha Drug Metabolism and Pharmacokinetics, Discovery Research, Dr. Reddy's Laboratories Ltd, Miyapur, Hyderabad, India
,
S. J. S. Basha Drug Metabolism and Pharmacokinetics, Discovery Research, Dr. Reddy's Laboratories Ltd, Miyapur, Hyderabad, India
,
R. Mullangi Drug Metabolism and Pharmacokinetics, Discovery Research, Dr. Reddy's Laboratories Ltd, Miyapur, Hyderabad, India
&
N. R. Srinivas Drug Metabolism and Pharmacokinetics, Discovery Research, Dr. Reddy's Laboratories Ltd, Miyapur, Hyderabad, India; Drug Development, Discovery Research, Dr. Reddy's Laboratories Ltd, Miyapur, Hyderabad, India
Pages 825-838 | Received 06 Apr 2005, Published online: 22 Sep 2008

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Rowan Stringer, Valerie Cordier, Catherine Afatsawo, Philip Arabin, Sandrine Desrayaud, Laurent Hoffmann, Daniel Lehmann, Philip John Lowe, Francis Risser, Julia Thiel, Toni Widmer, Peter Wipfli & Marc Bigaud. (2019) Utility of food pellets containing 1-aminobenzotriazole for longer term in vivo inhibition of cytochrome P450 in mice. Xenobiotica 49:1, pages 13-21.
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Xianqin Wang, Lufeng Hu, Shuhua Tong, Yangming Zheng, Faqing Ye, Dan Lin, Guanyang Lin, Xiuhua Zhang & Haiya Wu. (2010) Determination of Chlorzoxazone in Rat Plasma by LC-ESI-MS/MS and Its Application to a Pharmacokinetic Study. Analytical Letters 43:15, pages 2424-2431.
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Articles from other publishers (7)

Shahin Nilchi, Navid Neyshaburinezhad, Mohammadreza Rouini, Hoda Lavasani, Alireza Foroumadi & Yalda H. Ardakani. (2022) Study the effect of 3,4-Methylenedioxy methamphetamine on cytochrome P450 2E1 activity. Brazilian Journal of Pharmaceutical Sciences 58.
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Marc-Olivier Boily, Nathalie Chauret, Julie Laterreur, François A. Leblond, Chantal Boudreau, Marie-Claude Duquet, Jean-François Lévesque, Line Ste-Marie & Vincent Pichette. (2015) In Vitro and In Vivo Mechanistic Studies toward Understanding the Role of 1-Aminobenzotriazole in Rat Drug-Drug Interactions. Drug Metabolism and Disposition 43:12, pages 1960-1965.
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R. Eakins, J. Walsh, L. Randle, R. E. Jenkins, I. Schuppe-Koistinen, C. Rowe, P. Starkey Lewis, O. Vasieva, N. Prats, N. Brillant, M. Auli, M. Bayliss, S. Webb, J. A. Rees, N. R. Kitteringham, C. E. Goldring & B. K. Park. (2015) Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome. Scientific Reports 5:1.
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Rowan A. Stringer, Eckhard Weber, Bruno Tigani, Paul Lavan, Stephen Medhurst & Bindi Sohal. (2014) 1-Aminobenzotriazole Modulates Oral Drug Pharmacokinetics through Cytochrome P450 Inhibition and Delay of Gastric Emptying in Rats. Drug Metabolism and Disposition 42:7, pages 1117-1124.
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F. Woodward Hopf, Jeffrey A. Simms, Shao-Ju Chang, Taban Seif, Selena E. Bartlett & Antonello Bonci. (2011) Chlorzoxazone, an SK-Type Potassium Channel Activator Used in Humans, Reduces Excessive Alcohol Intake in Rats. Biological Psychiatry 69:7, pages 618-624.
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Qi-Biao Su, Fan He, Xue-Ding Wang, Su Guan, Zhi-Yong Xie, Lai-You Wang, Yu-Jing Lu, Lian-Quan Gu, Zhi-Shu Huang, Xiao Chen, Min Huang & Shu-Feng Zhou. (2007) Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat. Investigational New Drugs 26:2, pages 119-137.
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Anna M. Lee, Jiang Yue & Rachel F. Tyndale. (2006) In Vivo and in Vitro Characterization of Chlorzoxazone Metabolism and Hepatic CYP2E1 Levels in African Green Monkeys: Induction by Chronic Nicotine Treatment. Drug Metabolism and Disposition 34:9, pages 1508-1515.
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