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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 4
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Research Article

Aldehyde oxidase and its contribution to the metabolism of a structurally novel, functionally selective GABAA α5-subtype inverse agonist

D. O’Connor Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, UK
,
P. Jones Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, UK
,
M. S. Chambers Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, UK
,
R. Maxey Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, UK
,
H. J. Szekeres Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, UK
,
N. Szeto Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, UK
,
P. Scott-Stevens Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, UK
,
A. M. Macleod Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, UK
,
M. Braun Merck Research Laboratories, Rahway, NJ, USA
&
B. Cato Merck Research Laboratories, Rahway, NJ, USA
 show all
Pages 315-330 | Received 11 Nov 2005, Published online: 22 Sep 2008

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Ramakrishna Nirogi, Vishwottam Kandikere, Raghava Choudary Palacharla, Gopinadh Bhyrapuneni, Vijaya Bhargava Kanamarlapudi, Ranjith Kumar Ponnamaneni & Arun Kumar Manoharan. (2014) Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions. Xenobiotica 44:3, pages 197-204.
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Deepak Dalvie, Cathie Xiang, Ping Kang & Sue Zhou. (2013) Interspecies variation in the metabolism of zoniporide by aldehyde oxidase. Xenobiotica 43:5, pages 399-408.
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Enrico Garattini & Mineko Terao. (2012) The role of aldehyde oxidase in drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 8:4, pages 487-503.
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Maria Novella Romanelli & Fulvio Gualtieri. (2007) The quest for the treatment of cognitive impairment: α7 nicotinic and α5 GABAA receptor modulators. Expert Opinion on Therapeutic Patents 17:11, pages 1365-1377.
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Articles from other publishers (10)

Nenad Manevski, Lloyd King, William R. Pitt, Fabien Lecomte & Francesca Toselli. (2019) Metabolism by Aldehyde Oxidase: Drug Design and Complementary Approaches to Challenges in Drug Discovery. Journal of Medicinal Chemistry 62:24, pages 10955-10994.
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Sravani Adusumalli, Rohitash Jamwal, R. Scott Obach, Tim F. Ryder, Lorenzo Leggio & Fatemeh Akhlaghi. (2019) Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach. Drug Metabolism and Disposition 47:8, pages 874-882.
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Cristiano Mota, Catarina Coelho, Silke Leimkühler, Enrico Garattini, Mineko Terao, Teresa Santos-Silva & Maria João Romão. (2018) Critical overview on the structure and metabolism of human aldehyde oxidase and its role in pharmacokinetics. Coordination Chemistry Reviews 368, pages 35-59.
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T. E. Ballard, S. Wang, L. M. Cox, M. A. Moen, S. Krzyzewski, O. Ukairo & R. S. Obach. (2015) Application of a Micropatterned Cocultured Hepatocyte System To Predict Preclinical and Human-Specific Drug Metabolism. Drug Metabolism and Disposition 44:2, pages 172-179.
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Alexander V. LyubimovKevin Beaumont. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 26 .
Alexander V. LyubimovMichael Zientek, Ping Kang, Matthew J. Hutzler & Scott R. Obach. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 59 .
Russell J. Mortishire-Smith, Haiying Zhang & Kevin P. Bateman. 2011. Mass Spectrometry in Drug Metabolism and Disposition. Mass Spectrometry in Drug Metabolism and Disposition 407 448 .
David C. Pryde, Deepak Dalvie, Qiyue Hu, Peter Jones, R. Scott Obach & Thien-Duc Tran. (2010) Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery. Journal of Medicinal Chemistry 53:24, pages 8441-8460.
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Guido Achermann, Theresa M. Ballard, Francesca Blasco, Pierre-Emmanuel Broutin, Bernd Büttelmann, Holger Fischer, Martin Graf, Maria-Clemencia Hernandez, Peter Hilty, Frédéric Knoflach, Andreas Koblet, Henner Knust, Anke Kurt, James R. Martin, Raffaello Masciadri, Richard H.P. Porter, Heinz Stadler, Andrew W. Thomas, Gerhard Trube & Jürgen Wichmann. (2009) Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series. Bioorganic & Medicinal Chemistry Letters 19:19, pages 5746-5752.
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Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:3, pages 257-405.
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