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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 2-3
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Research Article

Metabolism, pharmacokinetics and excretion of a potent tachykinin NK1 receptor antagonist (CP-122,721) in rat: Characterization of a novel oxidative pathway

A. Kamel Pfizer Global Research and Development, Groton, CT, USA
,
J. Davis Pfizer Global Research and Development, Groton, CT, USA
,
M. J. Potchoiba Pfizer Global Research and Development, Groton, CT, USA
&
C. Prakash Pfizer Global Research and Development, Groton, CT, USA
Pages 235-258 | Received 27 Oct 2005, Published online: 22 Sep 2008

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A. Kamel, Y. Du, K. Colizza & C. Prakash. (2007) Metabolism and excretion of CP-122,721, a non-peptide antagonist of the neurokinin NK1 receptor, in dogs: Identification of the novel cleaved product 5-trifluoromethoxy salicylic acid in plasma. Xenobiotica 37:5, pages 559-578.
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Articles from other publishers (9)

Matthew Boyce, Kristin A. Favela, Jessica A. Bonzo, Alex Chao, Lucina E. Lizarraga, Laura R. Moody, Elizabeth O. Owens, Grace Patlewicz, Imran Shah, Jon R. Sobus, Russell S. Thomas, Antony J. Williams, Alice Yau & John F. Wambaugh. (2023) Identifying xenobiotic metabolites with in silico prediction tools and LCMS suspect screening analysis. Frontiers in Toxicology 5.
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Matthew H. Gieuw, Zhihai Ke & Ying-Yeung Yeung. (2017) Lewis Base Catalyzed Stereo- and Regioselective Bromocyclization. The Chemical Record 17:3, pages 287-311.
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Ling Zhou, Daniel Weiliang Tay, Jie Chen, Gulice Yiu Chung Leung & Ying-Yeung Yeung. (2013) Enantioselective synthesis of 2-substituted and 3-substituted piperidines through a bromoaminocyclization process. Chem. Commun. 49:39, pages 4412-4414.
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Dennis A. Smith & R. Scott Obach. (2009) Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment. Chemical Research in Toxicology 22:2, pages 267-279.
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L. Dihel, C. Kittleson, K. Mulvihill & W. W. Johnson. (2009) Oxidative Metabolism of the Trifluoromethoxy Moiety of OSI-930. Drug Metabolism and Drug Interactions 24:2-4.
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Kevin Colizza, Mohamed Awad & Amin Kamel. (2007) Metabolism, Pharmacokinetics, and Excretion of the Substance P Receptor Antagonist CP-122,721 in Humans: Structural Characterization of the Novel Major Circulating Metabolite 5-Trifluoromethoxy Salicylic Acid by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and NMR Spectroscopy. Drug Metabolism and Disposition 35:6, pages 884-897.
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Chandra Prakash, Christopher L. Shaffer & Angus Nedderman. (2007) Analytical strategies for identifying drug metabolites. Mass Spectrometry Reviews 26:3, pages 340-369.
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Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:3, pages 257-405.
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R. Scott Obach, Jeannine M. Margolis & Michael J. Logman. (2007) In Vitro Metabolism of CP-122,721 ((2S,3S)-2-Phenyl-3-[(5-Trifluoromethoxy-2-Methoxy)Benzylamino]Piperidine), a Non-Peptide Antagonist of the Substance P Receptor. Drug Metabolism and Pharmacokinetics 22:5, pages 336-349.
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