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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 6
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Research Article

Prediction of in vivo drug clearance from in vitro data. I: Impact of inter-individual variability

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Pages 473-497 | Received 23 Nov 2005, Published online: 22 Sep 2008

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Helen E. Cubitt, Karen R. Yeo, Eleanor M. Howgate, Amin Rostami-Hodjegan & Zoe E. Barter. (2011) Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model. Xenobiotica 41:8, pages 623-638.
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Karen Rowland Yeo, Mohsen Aarabi, Masoud Jamei & Amin Rostami-Hodjegan. (2011) Modeling and predicting drug pharmacokinetics in patients with renal impairment. Expert Review of Clinical Pharmacology 4:2, pages 261-274.
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Thierry Lavé, Kathryn Chapman, Paul Goldsmith & Malcolm Rowland. (2009) Human clearance prediction: shifting the paradigm. Expert Opinion on Drug Metabolism & Toxicology 5:9, pages 1039-1048.
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Pascal Espié, Dominique Tytgat, Maria-Laura Sargentini-Maier, Italo Poggesi & Jean-Baptiste Watelet. (2009) Physiologically based pharmacokinetics (PBPK). Drug Metabolism Reviews 41:3, pages 391-407.
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H. J. Einolf. (2007) Comparison of different approaches to predict metabolic drug–drug interactions. Xenobiotica 37:10-11, pages 1257-1294.
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T. Lavé, N. Parrott, H. P. Grimm, A. Fleury & M. Reddy. (2007) Challenges and opportunities with modelling and simulation in drug discovery and drug development. Xenobiotica 37:10-11, pages 1295-1310.
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Jan L Wahlstrom, Dan A Rock, J Greg Slatter & Larry C Wienkers. (2006) Advances in predicting CYP-mediated drug interactions in the drug discovery setting. Expert Opinion on Drug Discovery 1:7, pages 677-691.
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M. R. Shiran, N. J. Proctor, E. M. Howgate, K. Rowland-Yeo, G. T. Tucker & A. Rostami-Hodjegan. (2006) Prediction of metabolic drug clearance in humans: extrapolation allometric scaling. Xenobiotica 36:7, pages 567-580.
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S. Inoue, E. M. Howgate, K. Rowland-Yeo, T. Shimada, H. Yamazaki, G. T. Tucker & A. Rostami-Hodjegan. (2006) Prediction of in vivo drug clearance from in vitro data. II: Potential inter-ethnic differences. Xenobiotica 36:6, pages 499-513.
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