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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 8
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Research Article

Approach to the prediction of the contribution of major cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage

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Pages 671-683 | Received 13 Jan 2006, Published online: 22 Sep 2008

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Muhammad Nasir Kalam, Muhammad Fawad Rasool, Faleh Alqahtani, Imran Imran, Asim Ur Rehman & Naveed Ahmed. (2021) Development and Evaluation of a Physiologically Based Pharmacokinetic Drug-Disease Model of Propranolol for Suggesting Model Informed Dosing in Liver Cirrhosis Patients. Drug Design, Development and Therapy 15, pages 1195-1211.
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Li Di. (2017) Reaction phenotyping to assess victim drug-drug interaction risks. Expert Opinion on Drug Discovery 12:11, pages 1105-1115.
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Zhe Wang, Wei Sun, Cheng-Ke Huang, Li Wang, Meng-Ming ia, Xiao Cui, Guo-Xin Hu & Zeng-Shou Wang. (2015) Inhibitory effects of curcumin on activity of cytochrome P450 2C9 enzyme in human and 2C11 in rat liver microsomes. Drug Development and Industrial Pharmacy 41:4, pages 613-616.
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C. Desbans, C. Hilgendorf, M. Lutz, P. Bachellier, T. Zacharias, J. C. Weber, H. Dolgos, L. Richert & A.-L. Ungell. (2014) Prediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donors. Xenobiotica 44:1, pages 17-27.
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Hongjian Zhang, Carl D Davis, Michael W Sinz & A David Rodrigues. (2007) Cytochrome P450 reaction-phenotyping: an industrial perspective. Expert Opinion on Drug Metabolism & Toxicology 3:5, pages 667-687.
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S. V. Mandlekar, A. V. Rose, G. Cornelius, B. Sleczka, C. Caporuscio, J. Wang & P. H. Marathe. (2007) Development of an rat screen model to predict pharmacokinetic interactions of CYP3A4 substrates. Xenobiotica 37:9, pages 923-942.
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C. Emoto & K. Iwasaki. (2007) Relative roles of CYP2C19 and CYP3A4/5 in midazolam 1′-hydroxylation. Xenobiotica 37:6, pages 592-603.
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Hugues Chanteux, Maria Rosa, Claude Delatour, Johan Nicolaï, Eric Gillent, Sylvie Dell’Aiera & Anna-Lena Ungell. (2020) Application of Azamulin to Determine the Contribution of CYP3A4/5 to Drug Metabolic Clearance Using Human Hepatocytes. Drug Metabolism and Disposition 48:9, pages 778-787.
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Laura J. Kingsley, Gregory L. Wilson, Morgan E. Essex & Markus A. Lill. (2014) Combining Structure- and Ligand-Based Approaches to Improve Site of Metabolism Prediction in CYP2C9 Substrates. Pharmaceutical Research 32:3, pages 986-1001.
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Magang Shou & Anthony Y. H. Lu. (2009) Antibodies as a Probe in Cytochrome P450 Research. Drug Metabolism and Disposition 37:5, pages 925-931.
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Makiko Kusama, Kazuya Maeda, Koji Chiba, Akinori Aoyama & Yuichi Sugiyama. (2008) Prediction of the Effects of Genetic Polymorphism on the Pharmacokinetics of CYP2C9 Substrates from In Vitro Data. Pharmaceutical Research 26:4, pages 822-835.
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