Citations (29)
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Lei Men, Yunli Zhao, Hongxin Lin, Xing Tang & Zhiguo Yu. (2017) Evaluation of the tissue distribution, excretion, and cytochrome P450 induction studies of a potential antitumor agent, TM-2, in animals using LC-MS/MS. Xenobiotica 47:9, pages 800-806.
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Articles from other publishers (25)
Kalani Jayanetti, Kathryn Takemura, Hersh Bendale, Ashna Garg & Iwao Ojima. (2023) Recent advances in the strategic incorporation of fluorine into new-generation taxoid anticancer agents. Journal of Fluorine Chemistry 267, pages 110106.
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Lina Jia, Xiaoyun Gao, Yi Fang, Haotian Zhang, Lihui Wang, Xing Tang, Jingyu Yang & Chunfu Wu. (2022) TM2, a novel semi-synthetic taxoid, exerts anti-MDR activity in NSCLC by inhibiting P-gp function and stabilizing microtubule polymerization. Apoptosis 27:11-12, pages 1015-1030.
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Karolina Seborova, Kamila Koucka, Alzbeta Spalenkova, Petr Holy, Marie Ehrlichova, Tomas Sychra, Lei Chen, Hersh Bendale, Iwao Ojima, Cristian Sandoval-Acuña, Jaroslav Truksa, Pavel Soucek & Radka Vaclavikova. (2022) Anticancer regimens containing third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model. Frontiers in Pharmacology 13.
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Changwei Wang, Lei Chen, Yi Sun, Wanrong Guo, Adam K. Taouil & Iwao Ojima. (2022) Design, synthesis and SAR study of Fluorine-containing 3rd-generation taxoids. Bioorganic Chemistry 119, pages 105578.
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Da-Cheng Hao. 2021. Taxaceae and Cephalotaxaceae. Taxaceae and Cephalotaxaceae
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Dade Rong, Changwei Wang, Xiaomei Zhang, Yanli Wei, Mingming Zhang, Daiyuan Liu, Haider Farhan, Saleh Abdul Momen Ali, Yanbin Liu, Adam Taouil, Wanrong Guo, Yican Wang, Iwao Ojima, Shulan Yang & Haihe Wang. (2020) A novel taxane, difluorovinyl-ortataxel, effectively overcomes paclitaxel-resistance in breast cancer cells. Cancer Letters.
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Martin Krøyer Rasmussen. (2020) Porcine cytochrome P450 3A: current status on expression and regulation. Archives of Toxicology 94:6, pages 1899-1914.
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Iwao Ojima, Xin Wang, Yunrong Jing & Changwei Wang. (2018) Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery. Journal of Natural Products 81:3, pages 703-721.
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Iwao Ojima. (2017) Strategic incorporation of fluorine into taxoid anticancer agents for medicinal chemistry and chemical biology studies. Journal of Fluorine Chemistry 198, pages 10-23.
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Simin Zhao, Yuanyuan Zhang, Ping Ju, Liqiang Gu, Rui Zhuang, Longshan Zhao, Xing Tang, Kaishun Bi & Xiaohui Chen. (2016) Determination of 6258-70, a new semi-synthetic taxane, in rat plasma and tissues: Application to the pharmacokinetics and tissue distribution study. Journal of Pharmaceutical Analysis 6:4, pages 219-225.
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Lei Men, Yunli Zhao, Hongli Lin, Mingjing Yang, Hui Liu, Yanjie Shao, Ronghua Fan, Xing Tang & Zhiguo Yu. (2014) Application of an LC‐MS/MS method to the pharmacokinetics of TM‐2, a potential antitumour agent, in rats. Drug Testing and Analysis 7:6, pages 544-549.
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Lei Men, Yunli Zhao, Hongli Lin, Mingjing Yang, Hui Liu, Xing Tang & Zhiguo Yu. (2014)
Characterization of
in vitro
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Lei Men, Hongli Lin, Yunli Zhao, Hui Liu, Mingjing Yang, Ronghua Fan, Pei Wang, Xing Tang & Zhiguo Yu. (2014) Metabolism of TM-2, a potential antitumor drug, in rats by using LC-MS. Journal of Separation Science 37:6, pages 625-629.
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Iwao Ojima, Anushree Kamath & Joshua D. Seitz. 2014. Natural Products in Medicinal Chemistry. Natural Products in Medicinal Chemistry
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Iwao Ojima. (2013) Exploration of Fluorine Chemistry at the Multidisciplinary Interface of Chemistry and Biology. The Journal of Organic Chemistry 78:13, pages 6358-6383.
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Larissa Kuznetsova, Liang Sun, Jin Chen, Xianrui Zhao, Joshua Seitz, Manisha Das, Yuan Li, Jean M. Veith, Paula Pera, Ralph J. Bernacki, Shujun Xia, Susan B. Horwitz & Iwao Ojima. (2012) Synthesis and biological evaluation of novel 3?-difluorovinyl taxoids. Journal of Fluorine Chemistry 143, pages 177-188.
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Marie Ehrlichov?Iwao Ojima, Jin Chen, Radka V?clav?kov?Vlasta N?mcov?-F?rstov?Jana Vobo?ilov?Petr ?imek, Stanislav Horsk?Pavel Sou?ek, Jan Kov??Marek Brabec & Ivan Gut. (2012) Transport, metabolism, cytotoxicity and effects of novel taxanes on the cell cycle in MDA-MB-435 and NCI/ADR-RES cells. Naunyn-Schmiedeberg's Archives of Pharmacology 385:10, pages 1035-1048.
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Berta Otová, Iwao Ojima, Radka Václavíková, Jiří Hrdý, Marie Ehrlichová, Pavel Souček, Jana Vobořilová, Vlasta Němcová, Ilaria Zanardi, Stanislav Horský, Jan Kovář & Ivan Gut. (2011) Second-generation taxanes effectively suppress subcutaneous rat lymphoma: role of disposition, transport, metabolism, in vitro potency and expression of angiogenesis genes. Investigational New Drugs 30:3, pages 991-1002.
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14
C]3′-
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Donglu Zhang, Van T. Ly, Michael Lago, Yuan Tian, Jinping Gan, W. Griffith Humphreys & S. Nilgün Çömezoğlu. (2009)
CYP3A4-Mediated Ester Cleavage as the Major Metabolic Pathway of the Oral Taxane 3′-
tert
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N
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tert
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N
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