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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 10-11: Special Issue: The absorption, distribution, metabolism and excretion (ADME) transcriptome
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Original

Predictive models of hepatotoxicity using gene expression data from primary rat hepatocytes

L. Hultin-Rosenberg AstraZeneca R&D Södertälje, Södertälje, Sweden
,
S. Jagannathan AstraZeneca R&D Wilmington, Wilmington, DE, USA
,
K. C. Nilsson AstraZeneca R&D Södertälje, Södertälje, Sweden
,
S. A. Matis AstraZeneca R&D Wilmington, Wilmington, DE, USA
,
N. Sjögren AstraZeneca R&D Södertälje, Södertälje, Sweden
,
R. D. J. Huby AstraZeneca R&D Global Safety Assessment, Macclesfield, UK
,
A. H. Salter AstraZeneca R&D Södertälje, Södertälje, SwedenCorrespondence[email protected]
&
J. D. Tugwood AstraZeneca R&D Global Safety Assessment, Macclesfield, UK
 show all
Pages 1122-1139 | Received 05 Apr 2006, Accepted 20 May 2006, Published online: 11 Aug 2009

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Katarzyna R Przybylak & Mark TD Cronin. (2012) In silico models for drug-induced liver injury – current status. Expert Opinion on Drug Metabolism & Toxicology 8:2, pages 201-217.
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Feng Ge & Qing-Yu He. (2009) Genomic and proteomic approaches for predicting toxicity and adverse drug reactions. Expert Opinion on Drug Metabolism & Toxicology 5:1, pages 29-37.
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Donna L Mendrick & Kellye K Daniels. (2008) Biomarkers of drug-induced adverse events. Expert Review of Clinical Pharmacology 1:1, pages 81-91.
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Xiaomou Wei, Junmei Ai, Youping Deng, Xin Guan, David R Johnson, Choo Y Ang, Chaoyang Zhang & Edward J Perkins. (2014) Identification of biomarkers that distinguish chemical contaminants based on gene expression profiles. BMC Genomics 15:1.
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Adrian Roth & Thomas Singer. (2014) The application of 3D cell models to support drug safety assessment: Opportunities & challenges. Advanced Drug Delivery Reviews 69-70, pages 179-189.
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Alexander V. LyubimovMark Fielden & Christine Karbowski. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 29 .
Wei-Jiun Lin & James J Chen. (2012) Biomarker classifiers for identifying susceptible subpopulations for treatment decisions. Pharmacogenomics 13:2, pages 147-157.
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Chin Yee Liew, Yen Ching Lim & Chun Wei Yap. (2011) Mixed learning algorithms and features ensemble in hepatotoxicity prediction. Journal of Computer-Aided Molecular Design 25:9, pages 855-871.
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Wei-Jiun Lin & James J Chen. (2011) An approach to identifying preclinical biomarkers of susceptibility to drug-induced toxicity. Pharmacogenomics 12:4, pages 493-501.
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Edward J. Perkins, J. Kevin Chipman, Stephen Edwards, Tanwir Habib, Francesco Falciani, Ronald Taylor, Graham Van Aggelen, Chris Vulpe, Philipp Antczak & Alexandre Loguinov. (2011) Reverse engineering adverse outcome pathways. Environmental Toxicology and Chemistry 30:1, pages 22-38.
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Lina Hultin Rosenberg, Bo Franzén, Gert Auer, Janne Lehtiö & Jenny Forshed. (2010) Multivariate meta-analysis of proteomics data from human prostate and colon tumours. BMC Bioinformatics 11:1.
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Weida Tong & Donna L. Mendrick. 2010. Biomarkers. Biomarkers 7 24 .
Donald J. AbrahamBernard Testa. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 403 454 .
R.L. Grant, A.B. Combs & D. AcostaJr.Jr.. 2010. Comprehensive Toxicology. Comprehensive Toxicology 203 224 .
Mark Fielden. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Donna L MendrickLaura Schnackenberg. (2009) Genomic and metabolomic advances in the identification of disease and adverse event biomarkers. Biomarkers in Medicine 3:5, pages 605-615.
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Gregor Tuschl, Jens Hrach, Yvonne Walter, Philip G. Hewitt & Stefan O. Mueller. (2009) Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: A valuable model for in vitro toxicity and drug–drug interaction studies. Chemico-Biological Interactions 181:1, pages 124-137.
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Bernard Testa & Stefanie D. Krämer. (2009) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 6:5, pages 591-684.
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William R. Foster, Stefan U. Ruepp & Bruce D. Car. 2009. Annual Reports in Medicinal Chemistry Volume 44. Annual Reports in Medicinal Chemistry Volume 44 555 573 .
Alison Vickers. 2008. Genomics. Genomics 175 189 .
Donna L. Mendrick. (2008) Genomic and genetic biomarkers of toxicity. Toxicology 245:3, pages 175-181.
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Donna L. Mendrick. 2008. Essential Concepts in Toxicogenomics. Essential Concepts in Toxicogenomics 1 22 .
Daniel F. Carr, Ana Alfirevic, Jonathan D. Tugwood, Bryan J. Barratt, James Sherwood, John Smith, Munir Pirmohamed & B. Kevin Park. (2007) Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity. Pharmacogenetics and Genomics 17:11, pages 961-972.
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Timothy M. D. Ebbels, Hector C. Keun, Olaf P. Beckonert, Mary E. Bollard, John C. Lindon, Elaine Holmes & Jeremy K. Nicholson. (2007) Prediction and Classification of Drug Toxicity Using Probabilistic Modeling of Temporal Metabolic Data:  The Consortium on Metabonomic Toxicology Screening Approach. Journal of Proteome Research 6:11, pages 4407-4422.
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