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Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 3
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Research Article

Characterization of cytochrome P450s mediating ipriflavone metabolism in human liver microsomes

Y. Moon College of Pharmacy, Wonkwang University, Iksan, Korea
,
S. Y. Kim College of Pharmacy, Wonkwang University, Iksan, Korea
,
H. Y. Ji College of Pharmacy, Wonkwang University, Iksan, Korea
,
Y. K. Kim College of Pharmacy, Wonkwang University, Iksan, Korea
,
H.-J. Chae Department of Pharmacology, School of Medicine, Chonbuk National University, Jeonju, Korea; Clinical Trial Center, Chonbuk National University, Jeonju, Korea
,
S.-W. Chae Department of Pharmacology, School of Medicine, Chonbuk National University, Jeonju, Korea; Clinical Trial Center, Chonbuk National University, Jeonju, Korea
&
H. S. Lee College of Pharmacy, Wonkwang University, Iksan, Korea; Clinical Trial Center, Chonbuk National University, Jeonju, Korea
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Pages 246-259 | Received 25 Oct 2006, Accepted 30 Nov 2006, Published online: 22 Sep 2008

Citations (10)

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Read on this site (2)

Y. W. Kim, Y. K. Kim, D.-K. Kim & Y. Y. Sheen. (2008) Identification of human cytochrome P450 enzymes involved in the metabolism of IN-1130, a novel activin receptor-like kinase-5 (ALK5) inhibitor. Xenobiotica 38:5, pages 451-464.
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H. S. Lee, E. J. Park, H. Y. Ji, S. Y. Kim, G.-J. Im, S. M. Lee & I. J. Jang. (2008) Identification of cytochrome P450 enzymes responsible for N -dealkylation of a new oral erectogenic, mirodenafil. Xenobiotica 38:1, pages 21-33.
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Articles from other publishers (8)

Violetta Mohos, Tímea Bencsik, Gabriella Boda, Eszter Fliszár-Nyúl, Beáta Lemli, Sándor Kunsági-Máté & Miklós Poór. (2018) Interactions of casticin, ipriflavone, and resveratrol with serum albumin and their inhibitory effects on CYP2C9 and CYP3A4 enzymes. Biomedicine & Pharmacotherapy 107, pages 777-784.
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Xianbao Shi, Brianna Mackie, Gang Zhang, Shuman Yang, Yonggui Song, Dan Su, Yali Liu & Lina Shan. (2016) Identification of the Metabolic Enzyme Involved Morusin Metabolism and Characterization of Its Metabolites by Ultraperformance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (UPLC/Q-TOF-MS/MS). Evidence-Based Complementary and Alternative Medicine 2016, pages 1-10.
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Janne T. Backman, Anne M. Filppula, Mikko Niemi & Pertti J. Neuvonen. (2015) Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions. Pharmacological Reviews 68:1, pages 168-241.
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Juliana Macedo Delarmelina, Jean Carlos Vencioneck Dutra & Maria do Carmo Pimentel Batitucci. (2014) Antimutagenic activity of ipriflavone against the DNA-damage induced by cyclophosphamide in mice. Food and Chemical Toxicology 65, pages 140-146.
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Penelope M.Y. Or, Francis F.Y. Lam, Y.W. Kwan, C.H. Cho, C.P. Lau, H. Yu, G. Lin, Clara B.S. Lau, K.P. Fung, P.C. Leung & John H.K. Yeung. (2012) Effects of Radix Astragali and Radix Rehmanniae, the components of an anti-diabetic foot ulcer herbal formula, on metabolism of model CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms. Phytomedicine 19:6, pages 535-544.
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Svava Ósk Jónsdóttir, Tine Ringsted, Nikolai G. Nikolov, Marianne Dybdahl, Eva Bay Wedebye & Jay R. Niemelä. (2012) Identification of cytochrome P450 2D6 and 2C9 substrates and inhibitors by QSAR analysis. Bioorganic & Medicinal Chemistry 20:6, pages 2042-2053.
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Changhong Yun, Li Ding, Ye Leng, He Zhu, Aidong Wen & Lin Yang. (2012) Determination of ipriflavone in human plasma by LC-MS and its application in a pharmacokinetic study. Biomedical Chromatography 26:1, pages 123-128.
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Remigijus Didziapetris, Justas Dapkunas, Andrius Sazonovas & Pranas Japertas. (2010) Trainable structure–activity relationship model for virtual screening of CYP3A4 inhibition. Journal of Computer-Aided Molecular Design 24:11, pages 891-906.
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