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Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 5
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Research Article

Effect of enalapril on the in vitro and in vivo peptidyl cleavage of a potent VLA-4 antagonist

B. V. Karanam Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ, USA
,
A. Jayraj Biogen Inc., Cambridge, MA, USA
,
M. Rabe Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ, USA
,
Z. Wang Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ, USA
,
C. Keohane Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ, USA
,
J. Strauss Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ, USA
&
S. Vincent Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ, USA
 show all
Pages 487-502 | Received 26 Jan 2007, Accepted 05 Mar 2007, Published online: 22 Sep 2008

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Nourollah Ramroodi, Masood Khani, Zohre Ganjali, Mohammad Reza Javan, Nima Sanadgol, Roghayeh Khalseh, Hadi Ravan, Ehsan Sanadgol & Mohammad Abdollahi. (2015) Prophylactic Effect of BIO-1211 Small-Molecule Antagonist of VLA-4 in the EAE Mouse Model of Multiple Sclerosis. Immunological Investigations 44:7, pages 694-712.
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Articles from other publishers (9)

Yagmur Tasdemiroglu, McAlister Council-Troche, Miao Chen, Benjamin Ledford, Russell A. Norris, Steven Poelzing, Robert G. Gourdie & Jia-Qiang He. (2024) Degradation of the α-Carboxyl Terminus 11 Peptide: In Vivo and Ex Vivo Impacts of Time, Temperature, Inhibitors, and Gender in Rat . ACS Pharmacology & Translational Science.
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Tingting He, Daria Giacomini, Alessandra Tolomelli, Monica Baiula & Luca Gentilucci. (2024) Conjecturing about Small-Molecule Agonists and Antagonists of α4β1 Integrin: From Mechanistic Insight to Potential Therapeutic Applications. Biomedicines 12:2, pages 316.
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Monica Baiula, Michele Anselmi, Francesco Musiani, Alessia Ghidini, Jacopo Carbone, Alberto Caligiana, Andrea Maurizio, Santi Spampinato & Luca Gentilucci. (2023) Design, Pharmacological Characterization, and Molecular Docking of Minimalist Peptidomimetic Antagonists of α4β1 Integrin. International Journal of Molecular Sciences 24:11, pages 9588.
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Michele Anselmi, Monica Baiula, Santi Spampinato, Roberto Artali, Tingting He & Luca Gentilucci. (2023) Design and Pharmacological Characterization of α 4 β 1 Integrin Cyclopeptide Agonists: Computational Investigation of Ligand Determinants for Agonism versus Antagonism . Journal of Medicinal Chemistry.
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Michele Anselmi, Monica Baiula, Federica Santino, Junwei Zhao, Santi Spampinato, Natalia Calonghi & Luca Gentilucci. (2021) Design of α/β-Hybrid Peptide Ligands of α4β1 Integrin Equipped with a Linkable Side Chain for Chemoselective Biofunctionalization of Microstructured Materials. Biomedicines 9:11, pages 1737.
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Samantha Deianira Dattoli, Monica Baiula, Rossella De Marco, Andrea Bedini, Michele Anselmi, Luca Gentilucci & Santi Spampinato. (2018) DS‐70, a novel and potent α 4 integrin antagonist, is an effective treatment for experimental allergic conjunctivitis in guinea pigs . British Journal of Pharmacology 175:20, pages 3891-3910.
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Rossella De Marco, Alessandra Tolomelli, Eusebio Juaristi & Luca Gentilucci. (2016) Integrin Ligands with α/β‐Hybrid Peptide Structure: Design, Bioactivity, and Conformational Aspects. Medicinal Research Reviews 36:3, pages 389-424.
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Rossella De Marco, Giacomo Mazzotti, Samantha D. Dattoli, Monica Baiula, Santi Spampinato, Arianna Greco & Luca Gentilucci. (2015) 5‐aminomethyloxazolidine‐2,4‐dione hybrid α/β‐dipeptide scaffolds as inductors of constrained conformations: Applications to the synthesis of integrin antagonists. Peptide Science 104:5, pages 636-649.
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Samantha D. Dattoli, Rossella De Marco, Monica Baiula, Santi Spampinato, Arianna Greco, Alessandra Tolomelli & Luca Gentilucci. (2014) Synthesis and assay of retro-α4β1 integrin-targeting motifs. European Journal of Medicinal Chemistry 73, pages 225-232.
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