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Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 6
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Research Article

Relative roles of CYP2C19 and CYP3A4/5 in midazolam 1′-hydroxylation

& , PhD
Pages 592-603 | Received 19 Feb 2007, Accepted 22 Mar 2007, Published online: 22 Sep 2008

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Sicong Li, Xuting Li, Dingsheng Yuan, Bin Wang, Rui Yang, Min Zhang, Jinliang Li & Fuqiang Zeng. (2021) Effects of paeoniflorin on the activities and mRNA expression of rat CYP1A2, CYP2C11 and CYP3A1 enzymes in vivo. Xenobiotica 51:9, pages 961-967.
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Cyrille Marvalin, Mireille Denoux, Serge Pérard, Sébastien Roy & Robert Azerad. (2012) Microbial production of phase I and phase II metabolites of midazolam. Xenobiotica 42:3, pages 285-293.
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Helen E. Cubitt, Karen R. Yeo, Eleanor M. Howgate, Amin Rostami-Hodjegan & Zoe E. Barter. (2011) Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model. Xenobiotica 41:8, pages 623-638.
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Shu-Feng Zhou, Jun-Ping Liu & Balram Chowbay. (2009) Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metabolism Reviews 41:2, pages 89-295.
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Articles from other publishers (6)

Jian Lu, Yanjiao Shao, Xuan Qin, Daozhi Liu, Ang Chen, Dali Li, Mingyao Liu & Xin Wang. (2017) CRISPR knockout rat cytochrome P450 3A1/2 model for advancing drug metabolism and pharmacokinetics research. Scientific Reports 7:1.
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Shinya Hosaka, Norie Murayama, Masahiro Satsukawa, Shotaro Uehara, Makiko Shimizu, Kazuhide Iwasaki, Shunsuke Iwano, Yasuhiro Uno & Hiroshi Yamazaki. (2015) Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances. Biopharmaceutics & Drug Disposition 36:9, pages 636-643.
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K. Rowland Yeo, R.L. Walsky, M. Jamei, A. Rostami-Hodjegan & G.T. Tucker. (2011) Prediction of time-dependent CYP3A4 drug–drug interactions by physiologically based pharmacokinetic modelling: Impact of inactivation parameters and enzyme turnover. European Journal of Pharmaceutical Sciences 43:3, pages 160-173.
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Albert P. Li. (2009) Evaluation of Luciferin-Isopropyl Acetal as a CYP3A4 Substrate for Human Hepatocytes: Effects of Organic Solvents, Cytochrome P450 (P450) Inhibitors, and P450 Inducers. Drug Metabolism and Disposition 37:8, pages 1598-1603.
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Hege Christensen, Liv Mathiesen, Lillian W. Postvoll, Bjørn Winther & Espen Molden. (2009) Different Enzyme Kinetics of Midazolam in Recombinant CYP3A4 Microsomes from Human and Insect Sources. Drug Metabolism and Pharmacokinetics 24:3, pages 261-268.
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Robert A. B. van Waterschoot, Antonius E. van Herwaarden, Jurjen S. Lagas, Rolf W. Sparidans, Els Wagenaar, Cornelia M. M. van der Kruijssen, Joyce A. Goldstein, Darryl C. Zeldin, Jos H. Beijnen & Alfred H. Schinkel. (2008) Midazolam Metabolism in Cytochrome P450 3A Knockout Mice Can Be Attributed to Up-Regulated CYP2C Enzymes. Molecular Pharmacology 73:3, pages 1029-1036.
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