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Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 7
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Research Article

Absorption, distribution and excretion of the new thienopyridine agent prasugrel in rats

K. Hagihara Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan
,
A. Kurihara Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan
,
K. Kawai Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan
,
M. Kazui Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan
,
M. Takahashi Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan
,
K. Kawabata Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan
,
N. A. Farid Department of Drug Disposition, Lilly Research Laboratories, Eli Lilly and Company, IndianapolisUSA
&
T. Ikeda Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan
 show all
Pages 788-801 | Received 26 Feb 2007, Accepted 14 Apr 2007, Published online: 22 Sep 2008

Citations (8)

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Kapendra Sahu, C. Karthikeyan, N.S.Hari Narayana Moorthy & Piyush Trivedi. (2011) COMPARATIVE STUDY OF FORCED DEGRADATION BEHAVIOR OF PRASUGREL BY UPLC AND HPLC AND THE DEVELOPMENT OF VALIDATED STABILITY INDICATING ASSAY METHOD. Journal of Liquid Chromatography & Related Technologies 34:17, pages 1870-1884.
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R. L. Smith, T. A. Gillespie, T. J. Rash, A. Kurihara & N. A. Farid. (2007) Disposition and metabolic fate of prasugrel in mice, rats, and dogs. Xenobiotica 37:8, pages 884-901.
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Articles from other publishers (6)

Rana A. Alaaeddine, Ibrahim AlZaim, Safaa H. Hammoud, Aya Arakji, Ali H. Eid, Khaled S. Abd-Elrahman & Ahmed F. El-Yazbi. (2021) The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: impact beyond reduced clotting. Clinical Science 135:8, pages 1015-1051.
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Katsunobu Hagihara, Miho Kazui, Hidenori Ikenaga, Toshihiko Nanba, Kiichi Fusegawa, Takashi Izumi, Toshihiko Ikeda & Atsushi Kurihara. (2011) The Intestine As an Important Contributor to Prasugrel Active Metabolite Formation In Vivo. Drug Metabolism and Disposition 39:4, pages 565-570.
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David S. Small, Nagy A. Farid, Christopher D. Payne, Christopher S. Konkoy, Joseph A. Jakubowski, Kenneth J. Winters & Daniel E. Salazar. (2010) Effect of Intrinsic and Extrinsic Factors on the Clinical Pharmacokinetics and Pharmacodynamics of Prasugrel. Clinical Pharmacokinetics 49:12, pages 777-798.
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L. Testa, R. Bhindi, W. J. Van Gaal, R. A. Latini, S. Pizzocri, S. Lanotte, G. G. L. Biondi Zoccai, M. Valgimigli, M. L. Laudisa, N. Brambilla, A. P. Banning & F. Bedogni. (2010) What is the risk of intensifying platelet inhibition beyond clopidogrel? A systematic review and a critical appraisal of the role of prasugrel. QJM 103:6, pages 367-377.
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L. Testa, G. G. L. Biondi Zoccai, M. Valgimigli, R. A. Latini, S. Pizzocri, S. Lanotte, M. L. Laudisa, N. Brambilla, M. R. Ward, G. A. Figtree, F. Bedogni & R. Bhindi. (2010) Current Concepts on Antiplatelet Therapy: Focus on the Novel Thienopyridine and Non-Thienopyridine Agents. Advances in Hematology 2010, pages 1-7.
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Bernard Testa & Stefanie D. Krämer. (2009) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 6:5, pages 591-684.
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