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Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 7
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Research Article

Disposition of loratadine in healthy volunteers

R. Ramanathan Schering-Plough Research Institute, Kenilworth, NJ, USA
,
L. Reyderman Schering-Plough Research Institute, Kenilworth, NJ, USA
,
K. Kulmatycki Schering-Plough Research Institute, Kenilworth, NJ, USA
,
A.-D. Su Schering-Plough Research Institute, Kenilworth, NJ, USA
,
N. Alvarez Schering-Plough Research Institute, Kenilworth, NJ, USA
,
S. K. Chowdhury Schering-Plough Research Institute, Kenilworth, NJ, USA
,
K. B. Alton Schering-Plough Research Institute, Kenilworth, NJ, USA
,
M. A. Wirth Schering-Plough Research Institute, Kenilworth, NJ, USA
,
R. P. Clement Schering-Plough Research Institute, Kenilworth, NJ, USA
,
P. Statkevich Schering-Plough Research Institute, Kenilworth, NJ, USA
&
J. E. Patrick Schering-Plough Research Institute, Kenilworth, NJ, USA
 show all
Pages 753-769 | Received 29 Mar 2007, Accepted 21 May 2007, Published online: 22 Sep 2008

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Yu Zhang, Jiaming Zhang, Qiuchi Xu, Yimeng Wang, Wenying Wu, Weiping Wang, Xiaoting Li & Tianhong Zhang. (2021) Simultaneous Determination of Loratadine and Its Metabolite Desloratadine in Beagle Plasma by LC-MS/MS and Application for Pharmacokinetics Study of Loratadine Tablets and Omeprazole‑Induced Drug–Drug Interaction. Drug Design, Development and Therapy 15, pages 5109-5122.
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Silvi A. Chacko, Van T. Ly, Lisa J. Christopher & Jinping Gan. (2020) Hepatocyte spheroids as a viable in vitro model for recapitulation of complex in vivo metabolism pathways of loratadine in humans. Xenobiotica 50:6, pages 621-629.
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Guangyi Yang, Shufan Ge, Rashim Singh, Sumit Basu, Katherine Shatzer, Ming Zen, Jiong Liu, Yifan Tu, Chenning Zhang, Jinbao Wei, Jian Shi, Lijun Zhu, Zhongqiu Liu, Yuan Wang, Song Gao & Ming Hu. (2017) Glucuronidation: driving factors and their impact on glucuronide disposition. Drug Metabolism Reviews 49:2, pages 105-138.
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Federica Vacondio, Claudia Silva, Marco Mor & Bernard Testa. (2010) Qualitative structure-metabolism relationships in the hydrolysis of carbamates. Drug Metabolism Reviews 42:4, pages 551-589.
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Shu-Feng Zhou, Jun-Ping Liu & Balram Chowbay. (2009) Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metabolism Reviews 41:2, pages 89-295.
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Articles from other publishers (27)

Annika Yardy, Kirsten Entz, Dayna Bennett, Benjamin Macphail & Alex Adronov. (2023) Incorporation of Loratadine-Cyclodextrin Complexes in Oral Thin Films for Rapid Drug Delivery. Journal of Pharmaceutical Sciences.
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Daniel Porat, Oleg Dukhno, Ella Vainer, Sandra Cvijić & Arik Dahan. (2022) Antiallergic Treatment of Bariatric Patients: Potentially Hampered Solubility/Dissolution and Bioavailability of Loratadine, but Not Desloratadine, Post-Bariatric Surgery. Molecular Pharmaceutics 19:8, pages 2922-2936.
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Corey Jones, Manjinder S. Lall & Scott P. France. 2022. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.
Qian Li, Yue-E Wu, Kai Wang, Hai-Yan Shi, Yue Zhou, Yi Zheng, Guo-Xiang Hao, Yi-Lei Yang, Le-Qun Su, Wen-Qi Wang, Xin-Mei Yang & Wei Zhao. (2021) Developmental Pharmacogenetics of CYP2D6 in Chinese Children: Loratadine as a Substrate Drug. Frontiers in Pharmacology 12.
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Yuxin Zhang, Yihua Lu, Lijuan Wang, Yuan Tian & Zunjian Zhang. (2020) Pharmacokinetics and Tissue Distribution of Loratadine, Desloratadine and Their Active Metabolites in Rat based on a Newly Developed LC-MS/MS Analytical Method. Drug Research 70:11, pages 528-540.
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Manjinder S. Lall, Asser Bassyouni, James Bradow, Maria Brown, Mark Bundesmann, Jinshan Chen, Gregory Ciszewski, Anne E. Hagen, Dennis Hyek, Stephen Jenkinson, Bo Liu, R. Scott Obach, Senliang Pan, Usa Reilly, Neal Sach, Daniel J. Smaltz, Douglas K. Spracklin, Jeremy Starr, Melissa Wagenaar & Gregory S. Walker. (2020) Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure–Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H 1 Receptor Inverse Agonist . Journal of Medicinal Chemistry 63:13, pages 7268-7292.
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Zhongyang Shi, Chenguang Wang & Changquan Calvin Sun. (2020) Molecular Origin of the Distinct Tabletability of Loratadine and Desloratadine: Role of the Bonding Area – Bonding Strength Interplay. Pharmaceutical Research 37:7.
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Bart Hens, Marival Bermejo, Patrick Augustijns, Rodrigo Cristofoletti, Gregory Amidon & Gordon Amidon. (2020) Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola® on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b). Pharmaceutics 12:6, pages 566.
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Maria Rosaria Iesce, Margherita Lavorgna, Chiara Russo, Concetta Piscitelli, Monica Passananti, Fabio Temussi, Marina DellaGreca, Flavio Cermola & Marina Isidori. (2019) Ecotoxic effects of loratadine and its metabolic and light-induced derivatives. Ecotoxicology and Environmental Safety 170, pages 664-672.
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M Keerthana & M Vidyavathi. (2018) Screening and evaluation of fungal resources for loratadine metabolites. Journal of Biosciences 43:5, pages 823-833.
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Ragu Ramanathan, Anima Ghosal, Lakshmi Ramanathan, Kate Comstock, Helen Shen & Dil Ramanathan. (2018) HPLC–high-resolution mass spectrometry with polarity switching for increasing throughput of human in vitro cocktail drug–drug interaction assay . Bioanalysis 10:9, pages 659-672.
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Yong Ma, Yue Fu, S. Cyrus Khojasteh, Deepak Dalvie & Donglu Zhang. (2017) Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8). Journal of Medicinal Chemistry 60:21, pages 8691-8705.
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Yvonne Aratyn-Schaus & Ragu Ramanathan. (2016) Advances in high-resolution MS and hepatocyte models solve a long-standing metabolism challenge: the loratadine story. Bioanalysis 8:16, pages 1645-1662.
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X Han, SK Quinney, Z Wang, P Zhang, J Duke, Z Desta, JS Elmendorf, DA Flockhart & L Li. (2015) Identification and Mechanistic Investigation of Drug–Drug Interactions Associated With Myopathy: A Translational Approach. Clinical Pharmacology & Therapeutics 98:3, pages 321-327.
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Wenkui Li, John Doherty, Paul Moench, Jimmy Flarakos & Francis L.S. Tse. (2015) LC–MS/MS bioanalysis of loratadine (Claritin) in dried blood spot (DBS) samples collected by subjects in a clinical research study. Journal of Chromatography B 983-984, pages 117-124.
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Ruina Gao. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 5 .
Li Di, Haojing Rong & Bo Feng. (2012) Demystifying Brain Penetration in Central Nervous System Drug Discovery. Journal of Medicinal Chemistry 56:1, pages 2-12.
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Alexander V. LyubimovRonald E. White. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 40 .
Venkata Suresh Ponnuru, B.R. Challa & Ramarao Nadendla. (2012) Quantification of desloratadine in human plasma by LC-ESI-MS/MS and application to a pharmacokinetic study. Journal of Pharmaceutical Analysis 2:3, pages 180-187.
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Justin J. Kavanagh, Gary D. Grant & Shailendra Anoopkumar-Dukie. (2012) Low dosage promethazine and loratadine negatively affect neuromotor function. Clinical Neurophysiology 123:4, pages 780-786.
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Natalia Penner, Lin Xu & Chandra Prakash. (2012) Radiolabeled Absorption, Distribution, Metabolism, and Excretion Studies in Drug Development: Why, When, and How?. Chemical Research in Toxicology 25:3, pages 513-531.
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Lan Gao, Jing Li, Claudia Kasserra, Qi Song, Ali Arjomand, David Hesk & Swapan K Chowdhury. (2011) Precision and Accuracy in the Quantitative Analysis of Biological Samples by Accelerator Mass Spectrometry: Application in Microdose Absolute Bioavailability Studies. Analytical Chemistry 83:14, pages 5607-5616.
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Shu-Feng Zhou. (2009) Polymorphism of Human Cytochrome P450 2D6 and Its Clinical Significance. Clinical Pharmacokinetics 48:12, pages 761-804.
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Ragu Ramanathan, S Çömezoglu & W Humphreys. 2009. Using Mass Spectrometry for Drug Metabolism Studies, Second Edition. Using Mass Spectrometry for Drug Metabolism Studies, Second Edition 127 203 .
Nicolas Picard, Dorra Dridi, François-Ludovic Sauvage, Naceur A. Boughattas & Pierre Marquet. (2009) General unknown screening procedure for the characterization of human drug metabolites: Application to loratadine phase I metabolism. Journal of Separation Science 32:13, pages 2209-2217.
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Petia A. Shipkova, Jonathan L. Josephs & Mark Sanders. 2008. Mass Spectrometry in Drug Metabolism and Pharmacokinetics. Mass Spectrometry in Drug Metabolism and Pharmacokinetics 191 221 .
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