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Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 7
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Research Article

Hypolipidemic effects of silymarin are not mediated by the peroxisome proliferator-activated receptor alpha

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Pages 725-735 | Received 06 Apr 2007, Accepted 21 May 2007, Published online: 22 Sep 2008

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Martin Poruba, Ludmila Kazdová, Olena Oliyarnyk, Hana Malinská, Zuzana Matusková, Igor Tozzi di Angelo, Vojtech Skop & Rostislav Vecera. (2015) Improvement bioavailability of silymarin ameliorates severe dyslipidemia associated with metabolic syndrome. Xenobiotica 45:9, pages 751-756.
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Shooka Mohammadi, Omid Asbaghi, Reza Afrisham, Vida Farrokhi, Yasaman Jadidi, Fatemeh Mofidi & Damoon Ashtary-Larky. (2024) Impacts of Supplementation with Silymarin on Cardiovascular Risk Factors: A Systematic Review and Dose–Response Meta-Analysis. Antioxidants 13:4, pages 390.
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Naza Jalal Awla, Alaadin M. Naqishbandi & Younis Baqi. (2023) Preventive and Therapeutic Effects of Silybum marianum Seed Extract Rich in Silydianin and Silychristin in a Rat Model of Metabolic Syndrome . ACS Pharmacology & Translational Science 6:11, pages 1715-1723.
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Jan Soukop & Rostislav Večeřa. (2023) Recent advances in research of Silymarin and its components. Klinická farmakologie a farmacie 36:4, pages 146-149.
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Rostislav Vecera, Martin Poruba, Martina Hüttl, Hana Malinska, Olena Oliyarnyk, Irena Markova, Zuzana Racova, Jan Soukop & Ludmila Kazdova. (2022) Beneficial Effect of Fenofibrate and Silymarin on Hepatic Steatosis and Gene Expression of Lipogenic and Cytochrome P450 Enzymes in Non-Obese Hereditary Hypertriglyceridemic Rats. Current Issues in Molecular Biology 44:5, pages 1889-1900.
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Samaneh Soleymani, Mohammad Hossein Ayati, Mohammad Javad Mansourzadeh, Nazli Namazi & Arman Zargaran. (2022) The effects of Silymarin on the features of cardiometabolic syndrome in adults: A systematic review and meta‐analysis. Phytotherapy Research 36:2, pages 842-856.
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M. PORUBA, P. ANZENBACHER, Z. RACOVA, O. OLIYARNYK, M. HÜTTL, H. MALINSKA, I. MARKOVA, S. GURSKA, L. KAZDOVA & R. VECERA. (2019) The Effect of Combined Diet Containing n-3 Polyunsaturated Fatty Acids and Silymarin on Metabolic Syndrome in Rats. Physiological Research, pages S39-S50.
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Atefeh Tajmohammadi, Bibi Marjan Razavi & Hossein Hosseinzadeh. (2018) Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review . Phytotherapy Research 32:10, pages 1933-1949.
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Soraiya Ebrahimpour-koujan, Bahram Pourghassem Gargari, Majid Mobasseri, Hadi Valizadeh & Mohammad Asghari-Jafarabadi. (2018) Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. (silymarin) extract supplement: A Triple-blinded randomized controlled clinical trial. Phytomedicine 44, pages 39-44.
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M. PORUBA, Z. MATUŠKOVÁ, L. KAZDOVÁ, O. OLIYARNYK, H. MALÍNSKÁ, I. TOZZI DI ANGELO & R. VEČEŘA. (2015) Positive Effects of Different Drug Forms of Silybin in the Treatment of Metabolic Syndrome. Physiological Research, pages S507-S512.
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J. Orolin, R. Vecera, I. Markova, A. Zacharova & P. Anzenbacher. (2009) Differences in hepatic expression of genes involved in lipid homeostasis between hereditary hypertriglyceridemic rats and healthy Wistar rats and in their response to dietary cholesterol. Food and Chemical Toxicology 47:10, pages 2624-2630.
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