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Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 8
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Research Article

Disposition and metabolic fate of prasugrel in mice, rats, and dogs

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Pages 884-901 | Received 10 Apr 2007, Accepted 31 May 2007, Published online: 22 Sep 2008

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Jiaqi Shan & Hongbin Sun. (2013) The discovery and development of prasugrel . Expert Opinion on Drug Discovery 8:7, pages 897-905.
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K. Hagihara, M. Kazui, H. Ikenaga, T. Nanba, K. Fusegawa, M. Takahashi, A. Kurihara, O. Okazaki, N. A Farid & T. Ikeda. (2009) Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs. Xenobiotica 39:3, pages 218-226.
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K. Hagihara, A. Kurihara, K. Kawai, M. Kazui, M. Takahashi, K. Kawabata, N. A. Farid & T. Ikeda. (2007) Absorption, distribution and excretion of the new thienopyridine agent prasugrel in rats. Xenobiotica 37:7, pages 788-801.
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Benjamin M. Brainard & Sarah B. Shropshire. 2023. Small Animal Critical Care Medicine. Small Animal Critical Care Medicine 937 942 .
Alexandra Pfaff, Armelle M. de Laforcade & Elizabeth A. Rozanski. (2020) The Use of Antithrombotics in Critical Illness. Veterinary Clinics of North America: Small Animal Practice 50:6, pages 1351-1370.
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Steven W. Baertschi, Lindsay Maxwell-Backer, Matthew Clemens, Tim A. Smitka, Jerry R. Draper, K. Wayne Taylor, Andreas Kaerner & Patrick J. Jansen. (2019) The Degradation Chemistry of Prasugrel Hydrochloride: Part 1—Drug Substance. Journal of Pharmaceutical Sciences 108:9, pages 2842-2857.
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Patrick M. Dansette, Dan Levent, Assia Hessani & Daniel Mansuy. (2015) Bioactivation of Clopidogrel and Prasugrel: Factors Determining the Stereochemistry of the Thiol Metabolite Double Bond. Chemical Research in Toxicology 28:6, pages 1338-1345.
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Mahmoud M.H. Al Omari, Nidal A. Qinna, Iyad S. Rashid, Khaldoun A. Al-Sou’od & Adnan A. Badwan. 2015. 195 320 .
Benjamin M. Brainard. 2015. Small Animal Critical Care Medicine. Small Animal Critical Care Medicine 877 882 .
Patrick M. Dansette, Julien Rosi, Justine Debernardi, Gildas Bertho & Daniel Mansuy. (2012) Metabolic Activation of Prasugrel: Nature of the Two Competitive Pathways Resulting in the Opening of Its Thiophene Ring. Chemical Research in Toxicology 25:5, pages 1058-1065.
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Alexander V. LyubimovBernard Testa & André Pannatier. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 23 .
Bo Wiinberg, Lisbeth R. Jessen, Inge Tarnow & Annemarie T. Kristensen. (2012) Diagnosis and treatment of platelet hyperactivity in relation to thrombosis in dogs and cats. Journal of Veterinary Emergency and Critical Care 22:1, pages 42-58.
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Minoru Uchiyama, Hiroko Koda, Thomas Fischer, Juergen Mueller, Naotoshi Yamamura, Minoru Oguchi, Haruo Iwabuchi, Osamu Okazaki & Takashi Izumi. (2011) In Vitro Metabolism of Rivoglitazone, a Novel Peroxisome Proliferator-Activated Receptor γ Agonist, in Rat, Monkey, and Human Liver Microsomes and Freshly Isolated Hepatocytes. Drug Metabolism and Disposition 39:7, pages 1311-1319.
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David S. Small, Nagy A. Farid, Christopher D. Payne, Christopher S. Konkoy, Joseph A. Jakubowski, Kenneth J. Winters & Daniel E. Salazar. (2010) Effect of Intrinsic and Extrinsic Factors on the Clinical Pharmacokinetics and Pharmacodynamics of Prasugrel. Clinical Pharmacokinetics 49:12, pages 777-798.
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Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Haruo Iwabuchi, Minoru Ishikawa, Hiroyuki Kobayashi, Naoki Tanaka, Osamu Okazaki, Nagy A. Farid & Toshihiko Ikeda. (2010) Biotransformation of Prasugrel, a Novel Thienopyridine Antiplatelet Agent, to the Pharmacologically Active Metabolite. Drug Metabolism and Disposition 38:6, pages 898-904.
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L. Testa, R. Bhindi, W. J. Van Gaal, R. A. Latini, S. Pizzocri, S. Lanotte, G. G. L. Biondi Zoccai, M. Valgimigli, M. L. Laudisa, N. Brambilla, A. P. Banning & F. Bedogni. (2010) What is the risk of intensifying platelet inhibition beyond clopidogrel? A systematic review and a critical appraisal of the role of prasugrel. QJM 103:6, pages 367-377.
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Nagy A. Farid, Atsushi Kurihara & Steven A. Wrighton. (2013) Metabolism and Disposition of the Thienopyridine Antiplatelet Drugs Ticlopidine, Clopidogrel, and Prasugrel in Humans. The Journal of Clinical Pharmacology 50:2, pages 126-142.
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L. Testa, G. G. L. Biondi Zoccai, M. Valgimigli, R. A. Latini, S. Pizzocri, S. Lanotte, M. L. Laudisa, N. Brambilla, M. R. Ward, G. A. Figtree, F. Bedogni & R. Bhindi. (2010) Current Concepts on Antiplatelet Therapy: Focus on the Novel Thienopyridine and Non-Thienopyridine Agents. Advances in Hematology 2010, pages 1-7.
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Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Michiharu Yoshiike, Kokichi Honda, Osamu Okazaki, Nagy A. Farid & Toshihiko Ikeda. (2009) A Possible Mechanism for the Differences in Efficiency and Variability of Active Metabolite Formation from Thienopyridine Antiplatelet Agents, Prasugrel and Clopidogrel. Drug Metabolism and Disposition 37:11, pages 2145-2152.
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Bernard Testa. (2009) Drug Metabolism for the Perplexed Medicinal Chemist. Chemistry & Biodiversity 6:11, pages 2055-2070.
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Bernard Testa & Stefanie D. Krämer. (2009) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 6:5, pages 591-684.
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Patrick M. Dansette, Julie Libraire, Gildas Bertho & Daniel Mansuy. (2009) Metabolic Oxidative Cleavage of Thioesters: Evidence for the Formation of Sulfenic Acid Intermediates in the Bioactivation of the Antithrombotic Prodrugs Ticlopidine and Clopidogrel. Chemical Research in Toxicology 22:2, pages 369-373.
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Dennis A. Smith & R. Scott Obach. (2009) Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment. Chemical Research in Toxicology 22:2, pages 267-279.
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Nuggehally R. Srinivas. (2009) Pharmacokinetic Screening Strategy for Discovery Work-Use of Rodent Species: Lessons Learnt and Probing Newer Thoughts. Drug Metabolism and Pharmacokinetics 24:2, pages 197-198.
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